Insider Trading & Ownership of Marcio Souza

Location: South Plainfield, NJ
Summary: The estimated net worth of Marcio Souza is at least $22,995,715 dollars as of 12 Jan 2026. Marcio Souza is the Chief Executive Officer, Director of Praxis Precision Medicines, Inc. and owns shares of Praxis Precision Medicines, Inc. (PRAX) stock worth about $22.95M. Marcio Souza is the Director of Aeglea BioTherapeutics, Inc. and owns shares of Spyre Therapeutics, Inc. (SYRE) stock worth about $50.5K.
Signature: /s/ Alex Nemiroff, as Attorney-in-Fact
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Ownership of Marcio Souza

Symbol	Company	Relationship	Holdings Value	Past Year Net Change	Change %	Report Period
PRAX	Praxis Precision Medicines, Inc.	Chief Executive Officer, Director	$22,945,243			08 Jan 2026
SYRE	Spyre Therapeutics, Inc.	Director	$50,472			25 Aug 2022

Sym	Company	Class	Transaction	%	Value $	* Price $	Shares	Shares After	Date	Ownership

* An asterisk sign (*) next to the price indicates that the price is likely invalid.