| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 8.5% | $4,780,699 | 4,641,455 | Redmile Group, LLC | 30 Jun 2025 | |||
| HBM Healthcare Investments (Cayman) Ltd. | 8.4% | +27% | $2,205,000 | +$525,805 | 4,500,000 | +31% | HBM Healthcare Investments (Cayman) Ltd. | 31 Mar 2025 |
| TANG CAPITAL PARTNERS LP | 6.3% | $1,615,473 | 3,296,883 | TANG CAPITAL MANAGEMENT, LLC | 31 Dec 2024 | |||
| MILLENNIUM MANAGEMENT LLC | 6% | +18% | $5,706,871 | +$861,071 | 3,188,196 | +18% | Millennium Management LLC | 17 Oct 2025 |
| FMR LLC | 3.4% | $881,449 | 1,798,875 | FMR LLC | 29 Nov 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| venBio Partners LLC | 18% | 9,699,925 | 0% | 10% | $17,750,863 |
| Redmile Group, LLC | 6.3% | 3,332,983 | -1.7% | 0.59% | $6,099,359 |
| MILLENNIUM MANAGEMENT LLC | 4.9% | 2,622,861 | +432% | 0% | $4,799,836 |
| Almitas Capital LLC | 4.8% | 2,536,891 | -0.06% | 1.1% | $4,642,511 |
| VANGUARD GROUP INC | 2.9% | 1,528,619 | -4.5% | 0% | $2,797,372 |
| ACADIAN ASSET MANAGEMENT LLC | 2.3% | 1,220,825 | -3.7% | 0% | $2,233,000 |
| Driehaus Capital Management LLC | 1.5% | 795,777 | 0.01% | $1,456,272 | |
| TWO SIGMA ADVISERS, LP | 1.4% | 719,800 | +2.3% | 0% | $1,317,234 |
| AMERIPRISE FINANCIAL INC | 1.2% | 652,897 | 0% | $1,194,802 | |
| TWO SIGMA INVESTMENTS, LP | 1.1% | 606,671 | +27% | 0% | $1,110,208 |
| BANK OF AMERICA CORP /DE/ | 1% | 530,828 | -49% | 0% | $971,415 |
| Privium Fund Management B.V. | 0.96% | 509,059 | 0% | 0.17% | $931,578 |
| BANK OF MONTREAL /CAN/ | 0.89% | 474,781 | -29% | 0% | $868,849 |
| BlackRock, Inc. | 0.84% | 447,692 | -37% | 0% | $819,277 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.66% | 352,335 | +12% | 0% | $645,030 |
| JANE STREET GROUP, LLC | 0.34% | 180,416 | -11% | 0% | $330,161 |
| UBS Group AG | 0.32% | 172,570 | -40% | 0% | $315,803 |
| RENAISSANCE TECHNOLOGIES LLC | 0.31% | 164,499 | +93% | 0% | $301,033 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.21% | 113,063 | -31% | 0% | $206,905 |
| STATE STREET CORP | 0.21% | 111,928 | -9.9% | 0% | $204,828 |
| BANK OF NOVA SCOTIA | 0.2% | 105,858 | 0% | 0% | $193,720 |
| NORTHERN TRUST CORP | 0.18% | 95,160 | -30% | 0% | $174,143 |
| IEQ CAPITAL, LLC | 0.17% | 92,233 | 0% | $168,786 | |
| GSA CAPITAL PARTNERS LLP | 0.17% | 88,165 | +8.4% | 0.01% | $161,000 |
| MORGAN STANLEY | 0.16% | 85,290 | -27% | 0% | $156,081 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 37,992 | $41,031 | -$87 | 108% | 1 |
| 2025 Q3 | 27,785,299 | $51,273,440 | +$2,394,855 | 183% | 60 |
| 2025 Q2 | 29,072,911 | $12,569,366 | -$2,788,794 | 41.51% | 60 |
| 2025 Q1 | 34,764,459 | $21,657,477 | -$4,297,866 | 62.3% | 83 |
| 2024 Q4 | 41,028,903 | $68,515,849 | -$8,509,646 | 167% | 85 |
| 2024 Q3 | 45,458,855 | $83,126,318 | -$40,254,396 | 182% | 92 |
| 2024 Q2 | 48,512,647 | $292,408,667 | -$2,808,992 | 603% | 109 |
| 2024 Q1 | 45,775,215 | $510,406,593 | -$4,932,180 | 1,115% | 104 |
| 2023 Q4 | 35,654 | $530,888 | +$530,888 | 1,489% | 2 |
| 2023 Q3 | 33,283,050 | $159,762,114 | -$6,351,370 | 480% | 76 |
| 2023 Q2 | 34,283,564 | $257,463,245 | -$6,376,896 | 751% | 74 |
| 2023 Q1 | 35,697,467 | $161,353,347 | -$6,004,486 | 452% | 85 |
| 2022 Q4 | 36,433,730 | $410,607,763 | -$2,053,176 | 1,127% | 86 |
| 2022 Q3 | 36,027,559 | $344,783,761 | +$5,891,483 | 957% | 93 |
| 2022 Q2 | 35,473,772 | $286,977,201 | -$17,010,912 | 808.99% | 90 |
| 2022 Q1 | 36,780,532 | $621,647,079 | +$3,005,970 | 1,690% | 93 |
| 2021 Q4 | 36,267,690 | $779,408,495 | -$56,103,707 | 2,149% | 101 |
| 2021 Q3 | 34,488,155 | $2,547,285,171 | +$109,290,995 | 7,385.98% | 111 |
| 2021 Q2 | 33,299,638 | $1,820,804,682 | -$28,036,884 | 5,467.99% | 101 |
| 2021 Q1 | 32,235,034 | $2,373,321,361 | +$119,541,087 | 7,373.97% | 90 |
| 2020 Q4 | 30,524,457 | $2,626,526,882 | +$420,173,605 | 8,619.96% | 85 |
| 2020 Q3 | 27,250,196 | $1,027,708,220 | +$1,027,708,283 | 3,774.01% | 56 |