| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Sofinnova Crossover I | 9.4% | -18% | $713,115,682 | -$101,880,000 | 8,399,478 | -13% | Sofinnova Crossover I SLP | 28 Oct 2025 |
| TCG Crossover GP I, LLC | 9.1% | $603,774,500 | 7,111,596 | Chen Yu | 30 Sep 2025 | |||
| Invus Global Management, LLC | 8.5% | $32,099,671 | 5,403,985 | Invus Public Equities, L.P. | 02 Sep 2022 | |||
| Deep Track Capital, LP | 4.8% | $284,118,956 | 3,480,144 | Deep Track Capital, LP | 30 Jun 2025 | |||
| Venrock Healthcare Capital Partners III, L.P. | 0.8% | $48,964,292 | 576,729 | Venrock Healthcare Capital Partners III, L.P. | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 9.1% | 7,111,596 | +17% | 30% | $603,774,500 |
| UBS Group AG | 5.7% | 4,461,262 | +2561% | 0.07% | $378,761,144 |
| Darwin Global Management, Ltd. | 4% | 3,164,501 | 7.3% | $263,697,868 | |
| Point72 Asset Management, L.P. | 3.7% | 2,925,352 | +1642% | 0.54% | $248,362,385 |
| Cormorant Asset Management, LP | 2.5% | 1,950,000 | -8.5% | 11% | $165,555,000 |
| Paradigm Biocapital Advisors LP | 2% | 1,564,196 | 3.9% | $132,800,240 | |
| MORGAN STANLEY | 1.9% | 1,470,717 | +209% | 0.01% | $124,863,874 |
| Caligan Partners LP | 1.9% | 1,451,924 | -13% | 17% | $123,268,348 |
| FMR LLC | 1.8% | 1,430,673 | 0.01% | $121,464,138 | |
| ADAR1 Capital Management, LLC | 1.7% | 1,350,826 | -56% | 11% | $114,685,127 |
| Octagon Capital Advisors LP | 1.7% | 1,325,000 | +4.6% | 18% | $112,492,500 |
| MILLENNIUM MANAGEMENT LLC | 1.4% | 1,100,030 | -12% | 0.07% | $93,392,547 |
| Vestal Point Capital, LP | 1.3% | 1,000,000 | 3.9% | $84,900,000 | |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.3% | 977,629 | 0.13% | $83,000,702 | |
| BAKER BROS. ADVISORS LP | 1.1% | 875,796 | 0.54% | $74,355,080 | |
| FARALLON CAPITAL MANAGEMENT LLC | 1% | 805,000 | 0.39% | $68,344,500 | |
| Saturn V Capital Management LP | 1% | 801,224 | +29% | 15% | $68,023,918 |
| Aberdeen Group plc | 1% | 787,417 | +11% | 0.11% | $66,851,703 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 0.94% | 731,523 | 4.8% | $62,106,303 | |
| Fairmount Funds Management LLC | 0.91% | 713,434 | 5.4% | $60,570,547 | |
| CITADEL ADVISORS LLC | 0.87% | 681,785 | -46% | 0.05% | $57,883,546 |
| BOOTHBAY FUND MANAGEMENT, LLC | 0.77% | 597,931 | -31% | 1.3% | $50,764,342 |
| VR ADVISER, LLC | 0.74% | 576,729 | -57% | 2.8% | $48,964,292 |
| BVF INC/IL | 0.71% | 558,031 | 1.9% | $47,376,832 | |
| Nantahala Capital Management, LLC | 0.71% | 557,564 | -62% | 2.9% | $47,337,184 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 9,380 | $1,252,223 | +$420,707 | $134.85 | 4 |
| 2025 Q3 | 51,964,814 | $4,408,157,076 | +$2,126,922,768 | $84.90 | 165 |
| 2025 Q2 | 30,664,346 | $234,581,803 | -$5,694,976 | $7.65 | 43 |
| 2025 Q1 | 31,761,546 | $198,509,815 | +$9,164,589 | $6.25 | 46 |
| 2024 Q4 | 29,861,029 | $218,582,712 | +$7,328,421 | $7.32 | 47 |
| 2024 Q3 | 27,383,884 | $312,847,988 | -$8,252,199 | $11.52 | 40 |
| 2024 Q2 | 28,098,910 | $371,643,391 | +$761,392 | $13.22 | 38 |
| 2024 Q1 | 1,145,065 | $16,374,000 | -$7,778,667 | $14.30 | 3 |
| 2023 Q4 | 21,265,859 | $227,821,381 | +$223,242,326 | $10.70 | 30 |