| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 12% | +4.2% | $27,921,385 | +$1,222,450 | 25,383,077 | +4.6% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| PERCEPTIVE ADVISORS LLC | 7.9% | $40,738,260 | 21,785,166 | Perceptive Advisors LLC | 18 Nov 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | $18,564,311 | 21,338,288 | RA Capital Management, L.P. | 22 Aug 2025 | |||
| Point72 Asset Management, L.P. | 9.7% | +21% | $22,409,727 | +$4,006,213 | 20,372,479 | +22% | Point72 Asset Management, L.P. | 30 Sep 2025 |
| Adimab, LLC | 7.3% | -17% | $47,210,856 | -$448,106 | 20,262,170 | -0.94% | Adimab, LLC | 23 Dec 2025 |
| BIOTECHNOLOGY VALUE FUND L P | 7.4% | $17,598,400 | 16,000,000 | BVF PARTNERS L P/IL | 15 Oct 2025 | |||
| MITHRIL II LP | 4.8% | $12,365,738 | 11,241,580 | Mithril II LP | 22 Aug 2025 | |||
| Soleus Private Equity Fund III, L.P. | 5.1% | $11,933,915 | 10,850,000 | Soleus Capital Management, L.P. | 10 Oct 2025 | |||
| MAVERICK CAPITAL LTD | 8.5% | $8,899,333 | 10,229,118 | Maverick Capital, Ltd. | 30 Jun 2025 | |||
| M28 Capital Management LP | 4.6% | $8,306,978 | 9,548,250 | Marc Elia | 22 Aug 2025 | |||
| Polaris Venture Partners V, L.P. | 3% | $7,709,449 | 7,008,590 | Terrance McGuire | 22 Aug 2025 | |||
| FMR LLC | 4.8% | $3,003,285 | 5,775,549 | FMR LLC | 31 Dec 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 9.1% | 25,383,077 | 0.01% | $28,048,300 | |
| Point72 Asset Management, L.P. | 7.3% | 20,302,100 | 0.05% | $22,332,310 | |
| MAVERICK CAPITAL LTD | 6.8% | 18,970,913 | +85% | 0.28% | $20,868,004 |
| RA CAPITAL MANAGEMENT, L.P. | 6.2% | 17,119,096 | 0.23% | $18,831,006 | |
| Mithril II GP LP | 4.1% | 11,241,580 | 0% | 19% | $12,365,738 |
| Driehaus Capital Management LLC | 3.6% | 10,105,078 | 0.08% | $11,115,586 | |
| M28 Capital Management LP | 3.3% | 9,248,250 | 0% | 15% | $10,173,075 |
| ADAR1 Capital Management, LLC | 2.7% | 7,370,987 | 0.81% | $8,108,086 | |
| 683 Capital Management, LLC | 2.3% | 6,300,000 | +105% | 0.63% | $6,930,001 |
| VANGUARD GROUP INC | 2.1% | 5,762,894 | +47% | 0% | $6,339,184 |
| Redmile Group, LLC | 0.82% | 2,285,320 | 0% | 0.24% | $2,513,852 |
| Ikarian Capital, LLC | 0.75% | 2,078,706 | 0.52% | $2,286,577 | |
| Eversept Partners, LP | 0.74% | 2,047,265 | 0.17% | $2,251,992 | |
| MILLENNIUM MANAGEMENT LLC | 0.52% | 1,446,615 | +16% | 0% | $1,591,276 |
| BOOTHBAY FUND MANAGEMENT, LLC | 0.29% | 812,706 | 0.02% | $893,977 | |
| GSA CAPITAL PARTNERS LLP | 0.29% | 805,221 | +85% | 0.07% | $886,000 |
| MORGAN STANLEY | 0.28% | 780,127 | +52% | 0% | $858,139 |
| JANE STREET GROUP, LLC | 0.28% | 765,443 | +272% | 0% | $841,987 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.26% | 732,344 | +15% | 0% | $805,900 |
| BlackRock, Inc. | 0.26% | 718,888 | -57% | 0% | $790,777 |
| DEUTSCHE BANK AG\ | 0.21% | 585,385 | 0% | 0% | $643,924 |
| BARCLAYS PLC | 0.16% | 433,510 | +1194% | 0% | $476,861 |
| TANG CAPITAL MANAGEMENT LLC | 0.14% | 400,000 | 0% | 0.02% | $440,000 |
| TWO SIGMA INVESTMENTS, LP | 0.12% | 335,000 | +40% | 0% | $368,500 |
| STATE STREET CORP | 0.12% | 324,607 | +19% | 0% | $357,068 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 24,146 | $60,000 | +$60,000 | 248.49% | 1 |
| 2025 Q3 | 148,776,871 | $163,780,233 | +$101,491,472 | 110% | 76 |
| 2025 Q2 | 60,449,568 | $43,221,357 | -$6,829,965 | 71.5% | 65 |
| 2025 Q1 | 70,429,031 | $42,633,141 | -$3,650,232 | 60.53% | 80 |
| 2024 Q4 | 76,775,823 | $34,014,397 | -$5,344,506 | 44.31% | 74 |
| 2024 Q3 | 71,475,464 | $72,905,229 | -$4,774,582 | 102% | 75 |
| 2024 Q2 | 75,944,683 | $83,538,942 | -$14,393,664 | 110% | 81 |
| 2024 Q1 | 72,306,164 | $321,027,506 | +$73,114,712 | 444% | 84 |
| 2023 Q4 | 55,790,093 | $219,813,600 | +$10,200,901 | 394% | 59 |
| 2023 Q3 | 53,480,242 | $90,916,720 | -$3,860,602 | 170% | 56 |
| 2023 Q2 | 55,874,093 | $58,667,446 | -$4,298,144 | 105% | 55 |
| 2023 Q1 | 59,582,054 | $71,495,821 | +$82,771 | 120% | 69 |
| 2022 Q4 | 59,769,581 | $89,652,255 | -$6,217,381 | 150% | 79 |
| 2022 Q3 | 61,535,191 | $192,604,001 | +$3,488,394 | 313% | 68 |
| 2022 Q2 | 60,380,699 | $198,046,146 | +$1,534,527 | 328% | 67 |
| 2022 Q1 | 56,122,313 | $255,950,801 | -$37,275,076 | 456% | 68 |
| 2021 Q4 | 59,509,148 | $426,518,798 | -$11,321,779 | 725.99% | 75 |
| 2021 Q3 | 52,191,070 | $2,162,362,949 | +$2,162,362,484 | 4,224% | 66 |