| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| CITADEL ADVISORS LLC | 6.1% | $15,081,151 | 13,346,151 | Kenneth Griffin | 09 Jul 2025 | |||
| Belldegrun Arie | 5.6% | -1.7% | $15,708,747 | +$77,438 | 12,668,344 | +0.5% | Arie Belldegrun, M.D. | 30 Sep 2025 |
| BlackRock, Inc. | 5.3% | $15,686,608 | 11,450,079 | BlackRock, Inc. | 31 Mar 2025 | |||
| Chang David D | 4.9% | -2% | $13,931,298 | +$121,756 | 11,234,918 | +0.88% | David D. Chang, M.D., Ph.D. | 30 Sep 2025 |
| Lynx1 Capital Management LP | 5.2% | $14,898,371 | 10,874,723 | Lynx1 Capital Management LP | 31 Dec 2024 | |||
| FMR LLC | 4.9% | -58% | $14,009,416 | -$18,558,217 | 10,225,851 | -57% | FMR LLC | 28 Feb 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Pfizer Inc | 9.7% | 22,032,040 | 0% | 6.2% | $27,319,730 |
| TPG GP A, LLC | 8.3% | 18,716,306 | 0% | 1.3% | $23,208,219 |
| BlackRock, Inc. | 7.7% | 17,514,674 | -2.1% | 0% | $21,718,195 |
| CITADEL ADVISORS LLC | 6.2% | 13,971,557 | +36% | 0.01% | $17,324,731 |
| VANGUARD GROUP INC | 4% | 9,020,770 | +9.2% | 0% | $11,185,755 |
| PRIMECAP MANAGEMENT CO/CA/ | 3.1% | 7,079,308 | +24% | 0.01% | $8,778,342 |
| Woodline Partners LP | 1.9% | 4,360,608 | 0% | 0.03% | $5,407,154 |
| Frazier Life Sciences Management, L.P. | 1.7% | 3,868,750 | 0% | 0.14% | $4,797,250 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.7% | 3,833,885 | +1% | 0% | $4,754,796 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.6% | 3,677,474 | -8.8% | 0% | $4,561,000 |
| UBS Group AG | 1.6% | 3,571,157 | +75% | 0% | $4,428,235 |
| MILLENNIUM MANAGEMENT LLC | 1.5% | 3,390,026 | +126% | 0% | $4,203,632 |
| TWO SIGMA INVESTMENTS, LP | 1.5% | 3,383,644 | +110% | 0.01% | $4,195,719 |
| Patient Square Capital LP | 1.3% | 2,981,396 | +13% | 0.99% | $3,696,931 |
| Wildcat Capital Management, LLC | 1.3% | 2,920,787 | 0% | 2.5% | $3,621,776 |
| RENAISSANCE TECHNOLOGIES LLC | 1.3% | 2,893,812 | +73% | 0% | $3,588,327 |
| TWO SIGMA ADVISERS, LP | 1.2% | 2,781,600 | +57% | 0.01% | $3,449,184 |
| STATE STREET CORP | 1.2% | 2,755,378 | +1.2% | 0% | $3,416,669 |
| DIMENSIONAL FUND ADVISORS LP | 0.92% | 2,090,753 | -24% | 0% | $2,592,869 |
| AQR CAPITAL MANAGEMENT LLC | 0.82% | 1,853,554 | +2199% | 0% | $2,298,407 |
| Vida Ventures Advisors, LLC | 0.79% | 1,798,163 | 0% | 7.6% | $2,229,722 |
| Aberdeen Group plc | 0.7% | 1,582,265 | +82% | 0% | $1,962,009 |
| DAFNA Capital Management LLC | 0.61% | 1,380,118 | 0% | 0.42% | $1,711,346 |
| MORGAN STANLEY | 0.57% | 1,299,166 | +113% | 0% | $1,610,966 |
| NORTHERN TRUST CORP | 0.57% | 1,279,628 | +0.42% | 0% | $1,586,739 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 92,930 | $129,703 | +$30,469 | $1.37 | 4 |
| 2025 Q3 | 162,111,006 | $201,030,848 | -$24,340,243 | $1.24 | 167 |
| 2025 Q2 | 183,617,715 | $207,883,296 | -$15,409,901 | $1.13 | 154 |
| 2025 Q1 | 196,986,783 | $288,577,409 | +$11,151,082 | $1.46 | 167 |
| 2024 Q4 | 188,404,830 | $401,310,730 | -$12,951,875 | $2.13 | 169 |
| 2024 Q3 | 164,371,652 | $460,365,153 | -$1,960,306 | $2.80 | 152 |
| 2024 Q2 | 165,199,031 | $384,926,165 | +$75,173,711 | $2.33 | 168 |
| 2024 Q1 | 131,205,694 | $586,005,669 | +$41,663,072 | $4.47 | 158 |
| 2023 Q4 | 769,747 | $2,472,772 | -$677,258 | $3.21 | 3 |
| 2023 Q3 | 128,787,064 | $408,249,249 | -$15,675,875 | $3.17 | 149 |
| 2023 Q2 | 131,603,897 | $653,917,240 | +$73,825,404 | $4.97 | 165 |
| 2023 Q1 | 115,525,619 | $570,761,427 | +$24,488,348 | $4.94 | 170 |
| 2022 Q4 | 110,969,165 | $697,661,522 | +$17,094,998 | $6.29 | 160 |
| 2022 Q3 | 102,004,067 | $1,101,036,604 | +$60,201,207 | $10.80 | 175 |
| 2022 Q2 | 95,102,415 | $1,084,114,613 | +$106,595,298 | $11.40 | 150 |
| 2022 Q1 | 91,656,720 | $835,579,228 | +$16,210,908 | $9.11 | 172 |
| 2021 Q4 | 84,441,610 | $1,260,117,619 | -$107,692,749 | $14.92 | 164 |
| 2021 Q3 | 86,131,474 | $2,213,651,062 | +$36,043,218 | $25.70 | 164 |
| 2021 Q2 | 86,300,061 | $2,250,274,646 | -$84,501,881 | $26.08 | 178 |
| 2021 Q1 | 86,534,861 | $3,054,470,350 | -$11,359,921 | $35.30 | 166 |
| 2020 Q4 | 86,788,183 | $2,190,645,206 | +$104,550,405 | $25.24 | 155 |
| 2020 Q3 | 82,336,350 | $3,104,893,381 | -$164,166,264 | $37.71 | 155 |
| 2020 Q2 | 86,223,636 | $3,691,724,138 | +$661,660,811 | $42.82 | 167 |
| 2020 Q1 | 73,319,077 | $1,426,826,188 | +$28,190,602 | $19.44 | 112 |
| 2019 Q4 | 71,621,056 | $1,860,738,066 | +$104,849,838 | $25.98 | 113 |
| 2019 Q3 | 64,587,234 | $1,760,321,211 | +$43,617,370 | $27.26 | 92 |
| 2019 Q2 | 62,997,933 | $1,691,474,303 | +$161,175,863 | $26.85 | 93 |
| 2019 Q1 | 57,709,522 | $1,661,351,410 | +$80,500,340 | $28.91 | 86 |
| 2018 Q4 | 54,998,315 | $1,469,849,010 | +$1,469,848,998 | $26.93 | 79 |
| 2016 Q1 | 4,033 | $115,000 | $0 | $28.51 | 1 |