ANAPTYSBIO, INC - Common Stock, par value $0.001 per share (ANAB) Institutional Ownership

13F Institutional Holders and Ownership History from Q1 2017 to Q4 2025

Type / Class
Equity / Common Stock, par value $0.001 per share
Symbol
ANAB on Nasdaq
Shares outstanding
28,054,172
Price per share
$48.48
All holders as of 30 Sep 2025
Q3 2025
Total 13F shares
31,635,003
Total reported value
$968,941,233
% of total 13F portfolios
0%
Share change
-5,117,366
Value change
-$154,408,489
Number of holders
164
Price from insider filings
$48.48
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of ANAPTYSBIO, INC - Common Stock, par value $0.001 per share (ANAB) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
Point72 Asset Management, L.P. 7.7% +35% $40,664,913 +$11,624,056 2,368,370 +40% Point72 Asset Management, L.P. 31 Mar 2025
BlackRock, Inc. 6.2% -28% $32,637,491 -$11,119,704 1,900,844 -25% BlackRock, Inc. 31 Mar 2025
MORGAN STANLEY 6.3% $36,955,390 1,845,002 Morgan Stanley 30 Jun 2025
VANGUARD GROUP INC 5.2% +5.8% $30,797,126 +$405,107 1,537,550 +1.3% The Vanguard Group 30 Jun 2025
GOLDMAN SACHS GROUP INC 4.5% -14% $38,314,646 -$10,329,933 1,251,295 -21% THE GOLDMAN SACHS GROUP, INC. 30 Sep 2025
First Light Asset Management, LLC 3.1% -57% $26,474,603 -$42,907,347 864,618 -62% Mathew P. Arens 30 Sep 2025
MILLENNIUM MANAGEMENT LLC 2.9% -44% $39,442,003 -$29,733,912 813,571 -43% Millennium Management LLC 31 Dec 2025
FMR LLC 0.9% -88% $5,091,861 -$33,068,368 254,212 -87% FMR LLC 30 May 2025

As of 30 Sep 2025, 164 institutional investors reported holding 31,635,003 shares of ANAPTYSBIO, INC - Common Stock, par value $0.001 per share (ANAB). This represents 113% of the company’s total 28,054,172 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of ANAPTYSBIO, INC - Common Stock, par value $0.001 per share (ANAB) together control 96% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
EcoR1 Capital, LLC 28% 7,880,094 0% 12% $241,288,478
Point72 Asset Management, L.P. 8.1% 2,265,528 -8.5% 0.15% $69,370,467
BlackRock, Inc. 6.1% 1,722,324 -3.6% 0% $52,737,560
MORGAN STANLEY 5.5% 1,556,258 -17% 0% $47,652,620
MILLENNIUM MANAGEMENT LLC 5.4% 1,519,230 +646% 0.04% $46,518,823
VANGUARD GROUP INC 5.3% 1,476,989 -3.9% 0% $45,225,403
TANG CAPITAL MANAGEMENT LLC 4.8% 1,333,639 +0.21% 1.6% $40,836,026
First Light Asset Management, LLC 3.5% 990,161 -72% 2.9% $30,318,730
STATE STREET CORP 3.1% 873,432 +6.4% 0% $26,744,488
Assenagon Asset Management S.A. 3% 839,934 +4853% 0.04% $25,718,779
Sanofi 2.9% 821,917 0% 9.7% $25,167,099
Palo Alto Investors LP 2.4% 673,520 -17% 3.8% $20,623,182
Soleus Capital Management, L.P. 2.2% 626,040 +95% 1% $19,169,345
683 Capital Management, LLC 1.9% 547,000 +9.4% 1.5% $16,749,140
Woodline Partners LP 1.8% 501,023 0% 0.07% $15,341,324
GEODE CAPITAL MANAGEMENT, LLC 1.7% 473,626 +2.2% 0% $14,504,776
JACOBS LEVY EQUITY MANAGEMENT, INC 1.3% 378,452 +2.7% 0.05% $11,588,200
TWO SIGMA ADVISERS, LP 1.3% 373,700 +29% 0.02% $11,442,694
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 1.3% 370,458 +146% 0.01% $11,343,424
D. E. Shaw & Co., Inc. 1.2% 349,360 +211% 0.01% $10,697,403
Nuveen, LLC 1.2% 339,271 +4.9% 0% $10,388,479
GOLDMAN SACHS GROUP INC 1.2% 329,820 +18% 0% $10,099,089
PRICE T ROWE ASSOCIATES INC /MD/ 1.1% 299,311 -56% 0% $9,166,000
TWO SIGMA INVESTMENTS, LP 0.91% 256,420 +11% 0.01% $7,851,580
Sofinnova Investments, Inc. 0.91% 254,268 -75% 0.48% $7,785,686

Institutional Holders of ANAPTYSBIO, INC - Common Stock, par value $0.001 per share (ANAB) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 34,824 $1,688,718 -$24,653,659 $48.48 8
2025 Q3 31,635,003 $968,941,233 -$154,408,489 $30.62 164
2025 Q2 36,775,405 $816,417,703 -$61,528,585 $22.20 146
2025 Q1 39,955,702 $742,780,434 +$106,646,662 $18.59 150
2024 Q4 35,417,546 $468,933,524 -$87,870,160 $13.24 132
2024 Q3 33,628,905 $1,126,906,132 +$123,152,650 $33.50 162
2024 Q2 29,796,764 $746,667,101 +$16,029,967 $25.06 133
2024 Q1 28,787,541 $648,298,464 -$22,369,734 $22.52 103
2023 Q4 35,592 $762,381 $21.42 1
2023 Q3 30,283,809 $543,900,425 -$1,743,560 $17.96 115
2023 Q2 30,193,673 $614,163,005 -$16,327,621 $20.34 114
2023 Q1 31,002,733 $674,580,539 -$44,624,767 $21.76 109
2022 Q4 32,834,299 $1,017,521,612 -$10,553,418 $30.99 112
2022 Q3 32,555,880 $830,499,415 +$39,147,025 $25.51 106
2022 Q2 31,017,384 $629,647,400 +$27,629,201 $20.30 115
2022 Q1 29,561,730 $732,050,699 +$44,705,641 $24.74 122
2021 Q4 27,730,306 $963,649,058 +$8,824,428 $34.75 127
2021 Q3 27,534,680 $746,701,511 -$4,016,039 $27.12 122
2021 Q2 27,712,501 $718,578,348 -$34,347,167 $25.93 118
2021 Q1 29,148,680 $628,146,569 +$26,618,053 $21.55 116
2020 Q4 27,945,651 $600,834,314 -$16,377,650 $21.50 128
2020 Q3 27,187,915 $401,008,974 -$14,208,347 $14.75 123
2020 Q2 29,995,643 $670,115,259 -$15,323,242 $22.34 116
2020 Q1 29,196,073 $412,538,472 +$44,189,088 $14.13 109
2019 Q4 28,275,790 $459,476,003 -$240,857,178 $16.25 116
2019 Q3 29,041,948 $1,016,180,867 -$48,527,824 $34.99 118
2019 Q2 30,126,626 $1,699,589,512 +$125,657,029 $56.42 123
2019 Q1 29,109,228 $2,126,296,842 +$19,399,336 $73.05 127
2018 Q4 28,933,775 $1,845,630,233 +$3,290,106 $63.79 116
2018 Q3 26,021,890 $2,589,393,481 +$371,580,779 $99.77 125
2018 Q2 22,419,194 $1,592,641,873 +$105,930,365 $71.04 116
2018 Q1 24,342,866 $2,533,591,510 +$62,747,788 $104.08 133
2017 Q4 23,775,464 $2,394,651,180 +$692,667,436 $100.72 115
2017 Q3 17,626,116 $615,987,150 +$141,393,104 $34.95 69
2017 Q2 13,697,057 $327,784,635 -$8,740,075 $23.93 49
2017 Q1 13,764,320 $380,871,694 +$373,947,807 $27.75 48