| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 10% | -30% | $33,797,548 | -$14,072,892 | 11,081,163 | -29% | FMR LLC | 30 Sep 2025 |
| Satter Muneer A | 7.2% | $36,032,262 | 10,444,134 | Satter Muneer A | 19 Nov 2025 | |||
| VANGUARD GROUP INC | 5.3% | +8.2% | $17,797,092 | +$1,389,132 | 5,835,112 | +8.5% | The Vanguard Group | 30 Sep 2025 |
| Bain Capital Life Sciences Fund, L.P. | 4.9% | $7,243,715 | 5,249,069 | BCLS I Investco, LP | 31 Dec 2024 | |||
| Point72 Asset Management, L.P. | 0.1% | $131,693 | 95,430 | Point72 Asset Management, L.P. | 31 Mar 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 7.6% | 11,081,163 | -29% | 0% | $33,797,548 |
| BlackRock, Inc. | 5.4% | 7,899,008 | -0.8% | 0% | $24,091,974 |
| BVF INC/IL | 4.8% | 7,000,000 | 0% | 0.87% | $21,350,000 |
| Redmile Group, LLC | 4.3% | 6,300,644 | 0% | 1.9% | $19,216,964 |
| VANGUARD GROUP INC | 4% | 5,835,112 | +8.7% | 0% | $17,797,091 |
| Bain Capital Life Sciences Investors, LLC | 3.6% | 5,249,069 | 0% | 1.1% | $16,009,660 |
| Bellevue Group AG | 3.6% | 5,157,290 | 0% | 0.33% | $15,729,735 |
| MORGAN STANLEY | 2.1% | 3,029,848 | +264% | 0% | $9,241,037 |
| MILLENNIUM MANAGEMENT LLC | 1.9% | 2,822,823 | +12% | 0.01% | $8,609,610 |
| Woodline Partners LP | 1.8% | 2,638,275 | +150% | 0.04% | $8,046,739 |
| Opaleye Management Inc. | 1.8% | 2,600,000 | 1.1% | $7,930,000 | |
| Candriam S.C.A. | 1.7% | 2,534,230 | 0% | 0.04% | $7,729,402 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.7% | 2,436,944 | +6.7% | 0% | $7,434,061 |
| GOLDMAN SACHS GROUP INC | 1.7% | 2,406,432 | +48% | 0% | $7,339,618 |
| AMERIPRISE FINANCIAL INC | 1.5% | 2,192,354 | +1.2% | 0% | $6,686,681 |
| TFG Asset Management GP Ltd | 1.5% | 2,112,455 | -25% | 0.94% | $6,442,988 |
| STATE STREET CORP | 1.4% | 2,050,308 | +3.5% | 0% | $6,253,439 |
| SPHERA FUNDS MANAGEMENT LTD. | 1.2% | 1,794,387 | +1.7% | 1.3% | $5,472,880 |
| DEUTSCHE BANK AG\ | 1% | 1,504,349 | +194% | 0% | $4,588,264 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1% | 1,500,000 | 0.01% | $4,575,000 | |
| Balyasny Asset Management L.P. | 0.89% | 1,297,260 | 0.01% | $3,956,643 | |
| BANK OF AMERICA CORP /DE/ | 0.89% | 1,294,302 | -11% | 0% | $3,947,621 |
| J. Goldman & Co LP | 0.76% | 1,107,001 | 0.13% | $3,376,353 | |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 0.74% | 1,066,932 | -1.1% | 0.03% | $3,254,143 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0.68% | 980,285 | -0.73% | 0% | $2,989,869 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 47,835 | $241,780 | -$246,482 | 502.37% | 3 |
| 2025 Q3 | 101,393,828 | $309,259,133 | +$11,182,358 | 305% | 144 |
| 2025 Q2 | 99,449,067 | $238,679,312 | +$759,658 | 240% | 127 |
| 2025 Q1 | 99,491,910 | $192,037,326 | -$14,234,478 | 193% | 146 |
| 2024 Q4 | 111,907,472 | $574,087,837 | +$7,285,869 | 513% | 151 |
| 2024 Q3 | 109,990,075 | $651,286,272 | +$12,076,393 | 592% | 141 |
| 2024 Q2 | 107,381,777 | $526,167,096 | +$50,550,463 | 490% | 142 |
| 2024 Q1 | 94,762,361 | $679,439,764 | +$102,859,903 | 717% | 126 |
| 2023 Q4 | 19,070 | $86,578 | -$10,946 | 454% | 1 |
| 2023 Q3 | 53,312,574 | $125,814,355 | -$901,607 | 236% | 91 |
| 2023 Q2 | 53,372,682 | $187,870,375 | -$1,702,155 | 352% | 93 |
| 2023 Q1 | 53,952,545 | $207,581,535 | +$10,754,632 | 385% | 96 |
| 2022 Q4 | 47,049,561 | $243,269,266 | +$3,514,528 | 517% | 81 |
| 2022 Q3 | 46,265,065 | $285,915,000 | +$50,218,970 | 618% | 68 |
| 2022 Q2 | 37,287,884 | $140,514,057 | +$11,741,142 | 376.98% | 70 |
| 2022 Q1 | 35,613,808 | $97,230,060 | -$20,159,044 | 272.99% | 91 |
| 2021 Q4 | 38,165,954 | $438,786,894 | +$3,774,832 | 1,148.99% | 90 |
| 2021 Q3 | 38,055,922 | $708,635,015 | -$28,023,858 | 1,861% | 81 |
| 2021 Q2 | 38,758,080 | $871,497,672 | +$28,301,555 | 2,251.01% | 73 |
| 2021 Q1 | 37,426,974 | $1,040,768,344 | +$36,673,598 | 2,784% | 72 |
| 2020 Q4 | 34,960,735 | $873,036,496 | -$19,051,885 | 2,502.99% | 68 |
| 2020 Q3 | 34,842,574 | $1,039,585,431 | +$1,039,585,817 | 3,022.99% | 65 |