| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 15% | $273,383,018 | 6,907,100 | FMR LLC | 30 Jun 2025 | |||
| Fairmount Funds Management LLC | 10% | $229,546,677 | 5,776,881 | Peter Evan Harwin | 10 Oct 2025 | |||
| WELLINGTON MANAGEMENT GROUP LLP | 11% | +29% | $193,354,079 | +$42,724,077 | 4,885,146 | +28% | Wellington Management Group LLP | 31 Jul 2025 |
| RTW INVESTMENTS, LP | 6% | $86,244,685 | 2,712,097 | RTW Investments, LP | 31 Dec 2024 | |||
| BlackRock, Inc. | 5.5% | $99,691,136 | 2,518,725 | BlackRock, Inc. | 30 Jun 2025 | |||
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4.7% | $85,757,284 | 2,158,502 | DRIEHAUS CAPITAL MANAGEMENT LLC | 30 Sep 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 216 | $16,304 | +$5,510 | $75.48 | 1 |
| 2025 Q3 | 59,584,018 | $2,367,665,565 | +$56,490,678 | $39.73 | 172 |
| 2025 Q2 | 57,837,483 | $2,511,890,310 | -$147,323,035 | $43.43 | 180 |
| 2025 Q1 | 61,488,037 | $2,301,755,045 | +$131,273,428 | $37.36 | 165 |
| 2024 Q4 | 57,873,775 | $2,621,627,156 | +$63,332,211 | $45.30 | 156 |
| 2024 Q3 | 56,092,373 | $3,292,239,808 | +$134,061,710 | $58.74 | 139 |
| 2024 Q2 | 54,153,585 | $2,130,950,611 | -$9,265,142 | $39.35 | 137 |
| 2024 Q1 | 52,903,025 | $3,515,414,886 | +$773,333,688 | $66.45 | 138 |
| 2023 Q4 | 26,497 | $740,326 | +$740,326 | $27.94 | 2 |
| 2023 Q3 | 40,108,316 | $848,591,959 | +$848,589,611 | $21.30 | 72 |