| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 15% | +13% | $12,946,856 | +$1,644,911 | 21,403,300 | +15% | T. Rowe Price Investment Management, Inc. | 30 Sep 2025 |
| Vestal Point Capital, LP | 9.9% | $3,680,000 | 11,500,000 | Vestal Point Capital, LP | 31 Dec 2024 | |||
| Alyeska Investment Group, L.P. | 5.8% | $2,146,399 | 6,707,497 | Alyeska Investment Group, L.P. | 31 Dec 2024 | |||
| ALEXANDRIA REAL ESTATE EQUITIES, INC. | 4.3% | $1,690,000 | 6,500,000 | Alexandria Real Estate Equities, Inc. | 11 Dec 2025 | |||
| Propel Bio Management, LLC | 4.2% | $1,564,002 | 6,015,394 | Propel Bio Management, LLC | 29 Dec 2025 | |||
| Venrock Healthcare Capital Partners III, L.P. | 4.1% | -58% | $1,781,667 | -$1,996,029 | 5,567,709 | -53% | Venrock Healthcare Capital Partners III, L.P. | 31 Mar 2025 |
| BlackRock, Inc. | 3.7% | -54% | $2,087,790 | -$1,630,640 | 5,219,475 | -44% | BlackRock, Inc. | 30 Jun 2025 |
| VANGUARD GROUP INC | 3.3% | -34% | $1,893,605 | -$462,072 | 4,734,013 | -20% | The Vanguard Group | 30 Jun 2025 |
| Schonfeld Strategic Advisors LLC | 3.3% | -53% | $1,496,351 | -$1,309,934 | 4,676,097 | -47% | Schonfeld Strategic Advisors LLC | 31 Mar 2025 |
| PERCEPTIVE ADVISORS LLC | 2.4% | $915,200 | 2,860,000 | Perceptive Advisors LLC | 31 Dec 2024 | |||
| MORGAN STANLEY | 2.5% | -64% | $914,858 | -$1,906,110 | 2,858,931 | -68% | Morgan Stanley | 31 Jan 2025 |
| FRANKLIN RESOURCES INC | 1.7% | -70% | $641,088 | -$1,535,203 | 2,003,400 | -71% | Franklin Resources, Inc. | 31 Dec 2024 |
| JANUS HENDERSON GROUP PLC | 0% | -104% | $11,453 | -$3,862,118 | 35,791 | -100% | JANUS HENDERSON GROUP PLC | 31 Dec 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 14% | 21,403,300 | +15% | 0.01% | $12,842,000 |
| Vestal Point Capital, LP | 9.4% | 14,250,000 | +24% | 0.39% | $8,619,825 |
| Propel Bio Management, LLC | 7.5% | 11,285,420 | 0% | 6.8% | $6,826,551 |
| Knoll Capital Management, LLC | 5.2% | 7,799,687 | 0% | 2.5% | $4,711,010 |
| VANGUARD GROUP INC | 3.4% | 5,102,689 | +7.8% | 0% | $3,087,126 |
| Simplify Asset Management Inc. | 3% | 4,487,505 | 0% | 0.06% | $2,714,492 |
| BlackRock, Inc. | 2.5% | 3,843,733 | -26% | 0% | $2,325,074 |
| PNC Financial Services Group, Inc. | 1.9% | 2,901,184 | 0% | $1,755,216 | |
| Pathstone Holdings, LLC | 1.7% | 2,643,540 | 0% | 0.01% | $1,599,077 |
| MARSHALL WACE, LLP | 1.7% | 2,542,688 | +65% | 0% | $1,525,612 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.5% | 2,211,629 | +83% | 0% | $1,337,814 |
| Rock Springs Capital Management LP | 1.4% | 2,075,991 | 0% | 0.07% | $1,255,767 |
| FRANKLIN RESOURCES INC | 1.3% | 2,003,338 | 0% | 0% | $1,211,819 |
| MILLENNIUM MANAGEMENT LLC | 1.3% | 1,907,214 | -1.9% | 0% | $1,153,674 |
| UBS Group AG | 1.3% | 1,905,625 | +129% | 0% | $1,152,903 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.85% | 1,278,156 | +32% | 0% | $773,417 |
| Qube Research & Technologies Ltd | 0.77% | 1,167,269 | -36% | 0% | $706,081 |
| MORGAN STANLEY | 0.47% | 713,314 | +108% | 0% | $431,484 |
| Hudson Bay Capital Management LP | 0.45% | 673,764 | 0% | $407,560 | |
| DEUTSCHE BANK AG\ | 0.41% | 622,226 | -0% | 0% | $379,558 |
| STATE STREET CORP | 0.34% | 518,518 | +47% | 0% | $313,652 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.32% | 477,157 | -19% | 0% | $288,632 |
| Rockefeller Capital Management L.P. | 0.26% | 391,897 | 0% | $237,058 | |
| Hennion & Walsh Asset Management, Inc. | 0.19% | 282,848 | -1.8% | 0.01% | $171,095 |
| Birchview Capital, LP | 0.15% | 225,000 | -20% | 0.1% | $136,103 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 94,763,328 | $57,199,408 | +$5,274,161 | $0.6049 | 69 |
| 2025 Q2 | 88,058,885 | $27,371,087 | -$7,459,107 | $0.3111 | 72 |
| 2025 Q1 | 106,044,815 | $51,845,339 | -$6,334,869 | $0.4889 | 89 |
| 2024 Q4 | 115,064,985 | $98,537,629 | -$63,024,633 | $0.8562 | 115 |
| 2024 Q3 | 112,721,874 | $960,818,913 | +$78,176,291 | $8.50 | 132 |
| 2024 Q2 | 103,226,978 | $481,702,604 | +$36,986,259 | $4.67 | 96 |
| 2024 Q1 | 93,958,967 | $638,614,949 | +$219,981,220 | $6.80 | 90 |
| 2023 Q4 | 74,211 | $248,607 | +$114,607 | $3.35 | 3 |
| 2023 Q3 | 42,970,344 | $106,996,633 | +$29,097,315 | $2.49 | 53 |
| 2023 Q2 | 31,465,577 | $40,275,447 | +$15,796,728 | $1.28 | 37 |
| 2023 Q1 | 19,276,881 | $15,634,441 | +$123,386 | $0.8111 | 33 |
| 2022 Q4 | 19,356,004 | $14,709,202 | -$2,557,195 | $0.7600 | 34 |
| 2022 Q3 | 22,671,476 | $21,085,595 | -$3,111,066 | $0.9302 | 37 |
| 2022 Q2 | 26,599,107 | $25,217,765 | +$12,928,055 | $0.9481 | 44 |
| 2022 Q1 | 12,317,637 | $25,974,133 | -$34,488,747 | $2.11 | 65 |
| 2021 Q4 | 14,884,072 | $133,206,527 | -$7,905,162 | $8.95 | 63 |
| 2021 Q3 | 15,109,010 | $250,904,842 | -$6,059,661 | $16.60 | 67 |
| 2021 Q2 | 15,367,588 | $319,342,018 | +$9,971,179 | $20.78 | 67 |
| 2021 Q1 | 14,020,090 | $262,950,177 | +$48,106,175 | $18.76 | 65 |
| 2020 Q4 | 11,666,056 | $256,772,809 | -$1,664,771 | $22.01 | 64 |
| 2020 Q3 | 12,193,459 | $253,134,571 | -$3,365,537 | $20.76 | 62 |
| 2020 Q2 | 11,284,493 | $407,413,612 | +$70,291,696 | $36.15 | 68 |
| 2020 Q1 | 9,642,088 | $315,202,419 | +$155,197,467 | $32.69 | 60 |
| 2019 Q4 | 4,991,742 | $136,175,281 | +$71,228,487 | $27.28 | 45 |
| 2019 Q3 | 2,391,132 | $26,278,659 | +$2,238,633 | $10.99 | 27 |
| 2019 Q2 | 2,168,472 | $17,869,000 | +$17,869,011 | $8.24 | 12 |