| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| WESTFIELD CAPITAL MANAGEMENT CO LP | 9.2% | $788,713,858 | 5,528,239 | Westfield Capital Management Company, L.P. | 31 Dec 2024 | |||
| FMR LLC | 8% | $662,979,358 | 4,646,943 | FMR LLC | 31 Mar 2025 | |||
| JANUS HENDERSON GROUP PLC | 7.8% | -2.5% | $859,467,360 | -$20,821,968 | 4,323,059 | -2.4% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| Capital International Investors | 5.6% | $611,460,188 | 3,109,225 | Capital International Investors | 30 Jun 2025 | |||
| T. Rowe Price Investment Management, Inc. | 4.8% | -27% | $530,338,200 | -$182,106,580 | 2,667,563 | -26% | T. Rowe Price Investment Management, Inc. | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 19% | 10,281,496 | 0% | 25% | $2,044,064,220 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 9.5% | 5,259,909 | -3.5% | 4.4% | $1,045,722,561 |
| Avoro Capital Advisors LLC | 9.2% | 5,110,000 | +2.6% | 13% | $1,015,919,100 |
| FMR LLC | 8% | 4,471,733 | -1.3% | 0.05% | $889,025,151 |
| JANUS HENDERSON GROUP PLC | 7.8% | 4,323,059 | -2.4% | 0.39% | $859,415,657 |
| Artisan Partners Limited Partnership | 6.7% | 3,720,880 | -6.8% | 1.1% | $739,748,153 |
| Capital International Investors | 5.5% | 3,060,616 | +0.45% | 0.1% | $608,481,067 |
| T. Rowe Price Investment Management, Inc. | 4.8% | 2,666,618 | -26% | 0.32% | $530,151,000 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 3.4% | 1,882,781 | -1% | 0.12% | $374,315,689 |
| WELLINGTON MANAGEMENT GROUP LLP | 3.2% | 1,798,931 | +96% | 0.06% | $357,645,472 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.1% | 1,726,228 | -8% | 0.04% | $343,192,000 |
| FRANKLIN RESOURCES INC | 2.9% | 1,589,956 | -9.3% | 0.08% | $316,099,066 |
| PERCEPTIVE ADVISORS LLC | 2% | 1,088,501 | +13% | 6.3% | $216,404,884 |
| Invesco Ltd. | 1.7% | 917,903 | -3.1% | 0.03% | $182,488,296 |
| Polar Capital Holdings Plc | 1.5% | 857,911 | +2.4% | 0.82% | $170,561,286 |
| PRINCIPAL FINANCIAL GROUP INC | 1.4% | 793,677 | +2723% | 0.08% | $157,790,924 |
| GOLDMAN SACHS GROUP INC | 1.2% | 653,012 | +21% | 0.02% | $129,825,315 |
| Vestal Point Capital, LP | 1.1% | 600,000 | +200% | 5.4% | $119,286,000 |
| AMERIPRISE FINANCIAL INC | 1% | 562,936 | -4.3% | 0.03% | $111,917,306 |
| AMERICAN CENTURY COMPANIES INC | 0.98% | 544,606 | +2.6% | 0.06% | $108,274,297 |
| FIL Ltd | 0.83% | 459,340 | -1% | 0.07% | $91,321,385 |
| BlackRock, Inc. | 0.81% | 451,497 | -4.3% | 0% | $89,762,118 |
| MORGAN STANLEY | 0.73% | 406,761 | +60% | 0% | $80,868,155 |
| Spyglass Capital Management LLC | 0.7% | 388,647 | 4.1% | $77,266,910 | |
| ALLIANCEBERNSTEIN L.P. | 0.68% | 375,899 | -0.48% | 0.02% | $74,732,480 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 69,572 | $14,835,473 | +$1,284,512 | 21,324% | 7 |
| 2025 Q3 | 63,798,122 | $12,683,766,165 | +$232,138,542 | 19,881% | 276 |
| 2025 Q2 | 62,895,390 | $10,855,906,781 | -$373,772,963 | 17,260% | 245 |
| 2025 Q1 | 65,178,531 | $10,147,207,193 | +$223,137,113 | 15,586% | 240 |
| 2024 Q4 | 63,749,884 | $8,776,087,969 | +$115,852,691 | 13,767% | 211 |
| 2024 Q3 | 62,595,715 | $9,312,956,236 | +$237,477,944 | 14,931% | 219 |
| 2024 Q2 | 60,582,608 | $8,262,207,594 | -$25,108,613 | 13,638% | 201 |
| 2024 Q1 | 60,784,496 | $9,188,391,576 | +$194,926,420 | 15,117% | 189 |
| 2023 Q4 | 112,956 | $14,252,894 | +$9,813,773 | 12,595% | 4 |
| 2023 Q3 | 60,251,885 | $5,641,966,523 | -$73,659,278 | 9,364% | 155 |
| 2023 Q2 | 61,001,517 | $5,444,384,091 | -$43,596,050 | 8,925% | 153 |
| 2023 Q1 | 60,956,874 | $6,532,348,001 | -$599,238,692 | 10,722% | 158 |
| 2022 Q4 | 65,905,596 | $8,048,128,736 | -$71,111,968 | 12,213% | 179 |
| 2022 Q3 | 66,592,808 | $6,878,323,319 | +$156,051,485 | 10,326% | 172 |
| 2022 Q2 | 63,199,728 | $5,874,503,143 | +$101,790,666 | 9,295.99% | 160 |
| 2022 Q1 | 61,917,032 | $7,265,683,213 | +$414,385,574 | 11,736% | 167 |
| 2021 Q4 | 58,360,734 | $7,849,241,391 | -$60,375,593 | 13,453% | 166 |
| 2021 Q3 | 57,994,758 | $9,242,685,600 | +$506,032,986 | 15,939% | 163 |
| 2021 Q2 | 55,035,436 | $7,237,845,901 | +$271,910,179 | 13,154.99% | 170 |
| 2021 Q1 | 52,654,712 | $6,793,004,689 | -$266,902,917 | 12,887.97% | 171 |
| 2020 Q4 | 54,090,162 | $9,020,976,490 | +$126,944,869 | 16,678.02% | 169 |
| 2020 Q3 | 53,309,147 | $8,226,712,101 | +$764,432,402 | 15,431.99% | 148 |
| 2020 Q2 | 48,248,343 | $7,132,005,530 | +$38,828,525 | 14,789.98% | 149 |
| 2020 Q1 | 47,865,751 | $5,390,563,456 | +$190,930,122 | 11,260.95% | 142 |
| 2019 Q4 | 46,138,165 | $6,418,677,137 | -$13,135,201 | 13,911.99% | 138 |
| 2019 Q3 | 46,121,663 | $4,442,424,426 | -$194,323,622 | 9,632% | 126 |
| 2019 Q2 | 47,663,417 | $5,487,484,115 | +$237,889,859 | 11,515.01% | 132 |
| 2019 Q1 | 45,989,019 | $5,412,737,939 | +$712,057,309 | 11,770% | 137 |
| 2018 Q4 | 40,100,469 | $2,509,199,237 | -$10,826,185 | 6,264.99% | 102 |
| 2018 Q3 | 40,188,306 | $2,847,498,166 | +$44,455,447 | 7,086% | 94 |
| 2018 Q2 | 39,572,741 | $2,632,378,192 | +$96,236,760 | 6,652% | 99 |
| 2018 Q1 | 38,126,373 | $2,493,396,132 | +$345,130,806 | 6,539.99% | 89 |
| 2017 Q4 | 30,513,340 | $1,222,363,447 | +$52,891,520 | 4,005.97% | 64 |
| 2017 Q3 | 28,774,674 | $1,040,063,755 | +$201,305,468 | 3,624.99% | 59 |
| 2017 Q2 | 23,269,447 | $646,000,000 | +$76,066,932 | 2,776% | 34 |
| 2017 Q1 | 20,898,775 | $585,169,000 | +$9,050,404 | 2,800.03% | 34 |
| 2016 Q4 | 20,561,164 | $416,158,000 | +$130,782,705 | 2,024% | 30 |
| 2016 Q3 | 13,995,656 | $281,311,000 | +$4,791,136 | 2,009.99% | 22 |
| 2016 Q2 | 13,876,594 | $184,147,000 | +$10,182,250 | 1,326.99% | 23 |
| 2016 Q1 | 12,036,579 | $223,242,000 | +$9,842,698 | 1,855.03% | 25 |
| 2015 Q4 | 10,090,990 | $184,865,000 | +$3,824,983 | 1,831.97% | 24 |
| 2015 Q3 | 7,464,711 | $132,122,000 | +$7,983,334 | 1,769.93% | 23 |
| 2015 Q2 | 8,953,588 | $157,819,000 | -$7,995,077 | 1,767.68% | 31 |
| 2015 Q1 | 7,454,340 | $128,058,000 | +$128,058,095 | 1,734.96% | 34 |