| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 11% | $57,361,654 | 4,857,041 | Eventide Asset Management, LLC | 31 Jan 2025 | |||
| Zone Healthcare Holdings, LLC | 9.9% | +25% | $85,717,590 | +$17,618,729 | 4,313,920 | +26% | Dapice Joshua J. | 30 Sep 2025 |
| Farallon Capital Partners, L.P. | 9.7% | $77,057,854 | 4,203,920 | Dapice Joshua J. | 30 Jun 2025 | |||
| Wellington Hadley Harbor Aggregator IV, L.P. | 9% | +31% | $46,077,884 | +$11,810,000 | 3,901,599 | +34% | Wellington Hadley Harbor Aggregator IV, L.P. | 31 Mar 2025 |
| WELLINGTON MANAGEMENT GROUP LLP | 9% | $46,077,884 | 3,901,599 | Wellington Management Group LLP | 31 Mar 2025 | |||
| Soleus BB SPV, LLC | 8.8% | $44,822,977 | 3,795,341 | Soleus Capital Management, L.P. | 31 Mar 2025 | |||
| MORGAN STANLEY | 8.6% | +26% | $74,305,196 | +$16,109,185 | 3,739,567 | +28% | Morgan Stanley | 30 Sep 2025 |
| Sands Capital Life Sciences Pulse Fund II, L.P. | 8.2% | +13% | $65,440,171 | +$7,619,854 | 3,570,113 | +13% | Sands Capital Life Sciences Pulse Fund II. L.P. | 30 Jun 2025 |
| RTW INVESTMENTS, LP | 7.6% | $38,971,453 | 3,299,869 | RTW Investments, LP | 31 Mar 2025 | |||
| BlackRock, Inc. | 6.4% | $55,215,708 | 2,778,764 | BlackRock, Inc. | 30 Sep 2025 | |||
| VANGUARD GROUP INC | 5.1% | $44,035,596 | 2,216,185 | The Vanguard Group | 30 Sep 2025 | |||
| PERCEPTIVE ADVISORS LLC | 3.7% | $23,760,695 | 1,593,608 | Perceptive Advisors LLC | 31 Mar 2025 | |||
| MILLENNIUM MANAGEMENT LLC | 1.8% | -70% | $15,835,993 | -$29,602,207 | 796,964 | -65% | Millennium Management LLC | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 11% | 4,957,252 | +0.5% | 1.6% | $98,500,197 |
| FARALLON CAPITAL MANAGEMENT LLC | 9.9% | 4,313,920 | +2.6% | 0.48% | $85,717,590 |
| WELLINGTON MANAGEMENT GROUP LLP | 9% | 3,901,599 | 0% | 0.01% | $77,524,772 |
| Soleus Capital Management, L.P. | 8.9% | 3,870,158 | +1.3% | 4.1% | $76,900,039 |
| MORGAN STANLEY | 8.7% | 3,761,583 | +28% | 0% | $74,742,654 |
| Sands Capital Alternatives, LLC | 8.2% | 3,570,113 | 0% | 16% | $70,938,145 |
| RTW INVESTMENTS, LP | 7.6% | 3,299,191 | 0% | 0.81% | $65,554,925 |
| BlackRock, Inc. | 6.4% | 2,781,331 | +224% | 0% | $55,265,048 |
| VANGUARD GROUP INC | 5.1% | 2,216,185 | +213% | 0% | $44,035,595 |
| Omega Fund Management, LLC | 4.4% | 1,920,125 | -3.4% | 17% | $38,152,884 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2.7% | 1,168,415 | 0% | 0.36% | $23,216,406 |
| Driehaus Capital Management LLC | 2.4% | 1,058,975 | -8.7% | 0.15% | $21,041,833 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.1% | 917,553 | +193% | 0% | $18,235,786 |
| STATE STREET CORP | 1.9% | 826,302 | +259% | 0% | $16,418,621 |
| MILLENNIUM MANAGEMENT LLC | 1.8% | 796,964 | +47% | 0.01% | $15,835,675 |
| JANUS HENDERSON GROUP PLC | 1.5% | 650,825 | -2.2% | 0.01% | $12,931,893 |
| Vestal Point Capital, LP | 1.4% | 600,000 | +9.1% | 0.54% | $11,922,000 |
| MARSHALL WACE, LLP | 1.4% | 594,902 | -3.3% | 0.01% | $11,820,702 |
| Walleye Capital LLC | 1.4% | 591,187 | +171% | 0.1% | $11,746,886 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.1% | 487,658 | +53% | 0% | $9,691,000 |
| GOLDMAN SACHS GROUP INC | 0.92% | 399,253 | +28% | 0% | $7,933,157 |
| LORD, ABBETT & CO. LLC | 0.84% | 364,448 | -13% | 0.02% | $7,242,000 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.76% | 330,692 | +223% | 0% | $6,570,850 |
| NORTHERN TRUST CORP | 0.69% | 298,060 | +213% | 0% | $5,922,452 |
| PURA VIDA INVESTMENTS, LLC | 0.65% | 281,250 | 0% | 36% | $5,588,438 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 152,305 | $4,640,793 | +$4,583,723 | 3,047.01% | 4 |
| 2025 Q3 | 48,310,134 | $959,915,542 | +$85,339,905 | 1,987% | 127 |
| 2025 Q2 | 44,848,348 | $652,883,600 | +$53,846,942 | 1,456% | 114 |
| 2025 Q1 | 41,702,710 | $507,968,057 | +$504,374,152 | 1,224% | 102 |