| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 8.4% | $118,363,227 | 17,483,490 | BlackRock, Inc. | 31 Mar 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 7.3% | $116,143,592 | 15,302,186 | RA Capital Management, L.P. | 04 Nov 2025 | |||
| Flynn James E | 5.8% | $103,071,430 | 12,169,000 | Deerfield Mgmt, L.P. | 12 Sep 2025 | |||
| Avoro Capital Advisors LLC | 4.2% | $58,899,000 | 8,700,000 | Avoro Capital Advisors LLC | 31 Mar 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| VANGUARD GROUP INC | 10% | 21,790,881 | +6.1% | 0% | $165,392,786 |
| BlackRock, Inc. | 10% | 21,245,876 | -0.84% | 0% | $161,256,203 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 5.8% | 12,169,000 | +159% | 1.4% | $92,362,710 |
| STATE STREET CORP | 4.7% | 9,807,438 | +15% | 0% | $74,438,454 |
| Kynam Capital Management, LP | 4.5% | 9,390,270 | +11% | 5.3% | $71,272,149 |
| UBS Group AG | 2.8% | 5,967,737 | +6.3% | 0.01% | $45,295,124 |
| ALKEON CAPITAL MANAGEMENT LLC | 2.6% | 5,464,021 | -4.4% | 0.19% | $41,471,919 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 2.5% | 5,225,986 | +22% | 0.03% | $39,665,234 |
| MORGAN STANLEY | 2.5% | 5,202,958 | -2.4% | 0% | $39,490,449 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.4% | 5,052,307 | -0.05% | 0% | $38,353,050 |
| TWO SIGMA INVESTMENTS, LP | 2.1% | 4,419,629 | +3.1% | 0.05% | $33,544,984 |
| TWO SIGMA ADVISERS, LP | 2% | 4,240,712 | +0.29% | 0.06% | $32,187,004 |
| Hood River Capital Management LLC | 1.7% | 3,620,261 | +191% | 0.32% | $27,477,781 |
| Nuveen, LLC | 1.7% | 3,617,882 | +2.4% | 0.01% | $27,459,724 |
| Assenagon Asset Management S.A. | 1.5% | 3,092,592 | -15% | 0.03% | $23,472,773 |
| GOLDMAN SACHS GROUP INC | 1.3% | 2,711,806 | -23% | 0% | $20,582,607 |
| Fisher Asset Management, LLC | 1.3% | 2,632,696 | -5.4% | 0.01% | $19,982,161 |
| Qube Research & Technologies Ltd | 1.1% | 2,410,362 | +1.6% | 0.03% | $18,294,648 |
| GW&K Investment Management, LLC | 1% | 2,197,765 | -16% | 0.15% | $16,681,000 |
| RENAISSANCE TECHNOLOGIES LLC | 1% | 2,140,534 | -15% | 0.02% | $16,246,653 |
| BNP PARIBAS FINANCIAL MARKETS | 1% | 2,094,278 | 0% | 0.01% | $15,895,570 |
| JUPITER ASSET MANAGEMENT LTD | 0.98% | 2,055,915 | -1.1% | 0.13% | $15,604,395 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.95% | 1,994,404 | +1.2% | 0% | $15,137,526 |
| BANK OF AMERICA CORP /DE/ | 0.91% | 1,902,819 | -33% | 0% | $14,442,397 |
| NORTHERN TRUST CORP | 0.9% | 1,892,043 | -1.1% | 0% | $14,360,607 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 777,006 | $6,056,979 | -$22,159,737 | 779.95% | 6 |
| 2025 Q3 | 194,113,722 | $1,473,202,263 | -$36,093,980 | 759% | 281 |
| 2025 Q2 | 197,129,798 | $1,766,723,682 | +$203,493,402 | 896% | 292 |
| 2025 Q1 | 174,241,947 | $1,307,295,119 | +$63,398,498 | 750% | 272 |
| 2024 Q4 | 167,634,434 | $1,260,963,178 | -$35,871,411 | 752% | 255 |
| 2024 Q3 | 172,461,082 | $1,310,699,249 | -$17,336,963 | 760% | 256 |
| 2024 Q2 | 174,329,025 | $1,077,168,420 | -$19,756,856 | 618% | 238 |
| 2024 Q1 | 178,794,692 | $908,282,297 | +$13,485,290 | 508% | 235 |
| 2023 Q4 | 995,388 | $5,966,374 | -$2,259,291 | 599% | 3 |
| 2023 Q3 | 174,862,085 | $1,237,990,036 | +$20,589,255 | 708% | 227 |
| 2023 Q2 | 173,206,131 | $1,219,704,380 | +$8,684,728 | 704% | 231 |
| 2023 Q1 | 170,642,621 | $1,423,147,428 | +$92,086,582 | 834% | 236 |
| 2022 Q4 | 156,295,197 | $1,794,049,107 | +$88,196,374 | 1,148% | 222 |
| 2022 Q3 | 146,813,145 | $1,849,838,441 | -$41,569,875 | 1,260% | 213 |
| 2022 Q2 | 146,233,112 | $1,547,163,393 | +$165,531,197 | 1,058% | 201 |
| 2022 Q1 | 126,959,618 | $2,062,986,346 | +$165,963,093 | 1,626% | 214 |
| 2021 Q4 | 117,818,574 | $1,621,609,826 | +$192,813,352 | 1,385% | 195 |
| 2021 Q3 | 103,285,552 | $1,484,285,647 | -$24,064,477 | 1,437% | 193 |
| 2021 Q2 | 104,610,942 | $1,653,827,922 | +$17,817,538 | 1,580.99% | 190 |
| 2021 Q1 | 104,349,292 | $1,061,228,812 | -$140,145,824 | 1,017% | 182 |
| 2020 Q4 | 120,522,116 | $897,817,805 | -$44,459,095 | 745% | 171 |
| 2020 Q3 | 127,492,897 | $438,150,012 | -$23,520,218 | 343.5% | 148 |
| 2020 Q2 | 130,802,567 | $623,563,637 | +$86,629,537 | 476.49% | 155 |
| 2020 Q1 | 122,545,605 | $245,076,906 | -$37,554,838 | 200% | 127 |
| 2019 Q4 | 136,461,895 | $470,563,973 | +$128,774,005 | 345% | 126 |
| 2019 Q3 | 97,207,334 | $278,518,178 | -$6,766,703 | 286.5% | 105 |
| 2019 Q2 | 99,769,274 | $378,061,222 | -$88,271,855 | 378.99% | 109 |
| 2019 Q1 | 100,836,648 | $820,777,210 | -$625,456 | 814% | 126 |
| 2018 Q4 | 100,991,756 | $815,022,643 | +$8,360,187 | 807% | 115 |
| 2018 Q3 | 100,110,755 | $763,814,804 | +$74,212,788 | 763% | 108 |
| 2018 Q2 | 87,369,622 | $500,633,833 | -$8,950,141 | 573.01% | 96 |
| 2018 Q1 | 89,040,228 | $424,731,405 | -$6,559,729 | 477% | 97 |
| 2017 Q4 | 90,256,578 | $443,198,769 | +$31,862,065 | 491% | 110 |
| 2017 Q3 | 83,551,707 | $436,150,628 | +$74,612,419 | 524% | 115 |
| 2017 Q2 | 68,664,954 | $381,777,979 | +$5,091,371 | 556% | 109 |
| 2017 Q1 | 67,622,424 | $566,335,791 | +$138,336,571 | 839.99% | 113 |
| 2016 Q4 | 58,390,925 | $369,592,679 | +$11,847,838 | 633% | 107 |
| 2016 Q3 | 56,535,325 | $249,323,126 | +$24,615,920 | 441% | 97 |
| 2016 Q2 | 51,199,104 | $145,407,142 | -$10,363,828 | 284% | 89 |
| 2016 Q1 | 53,854,466 | $152,388,490 | -$59,466,616 | 282.99% | 98 |
| 2015 Q4 | 63,010,560 | $650,239,667 | -$41,772,947 | 1,031.98% | 116 |
| 2015 Q3 | 63,700,390 | $726,067,332 | +$33,949,200 | 1,140% | 121 |
| 2015 Q2 | 62,218,189 | $928,841,410 | +$39,236,791 | 1,492.97% | 119 |
| 2015 Q1 | 58,019,025 | $523,923,031 | +$37,779,102 | 903% | 95 |
| 2014 Q4 | 53,661,254 | $652,337,154 | +$25,558,717 | 1,216% | 87 |
| 2014 Q3 | 56,671,269 | $554,269,573 | -$6,975,870 | 978% | 100 |
| 2014 Q2 | 49,824,717 | $635,343,598 | +$146,396,546 | 1,275% | 98 |
| 2014 Q1 | 43,477,549 | $460,381,679 | +$93,247,043 | 1,057.99% | 85 |