Blueprint Medicines Corp - Common Stock, par value $0.001 per share (BPMC) Institutional Ownership

13F Institutional Holders and Ownership History from Q2 2015 to Q3 2025

Type / Class: Equity / Common Stock, par value $0.001 per share
Symbol: BPMC
Shares outstanding: 62,500,000
Price per share: $128.79
All holders as of 30 Sep 2025: Q3 2025
Total 13F shares: 26,105
Total reported value: $2,576,619
% of total 13F portfolios: 0%
Share change: -64,211,585
Value change: -$8,230,672,915
Number of holders: 5
Price from insider filings: $128.79

Reported Shares, Excluding Options vs Price

Reported Value, Excluding Options

Total Investors

Significant Owners of Blueprint Medicines Corp - Common Stock, par value $0.001 per share (BPMC) based on Schedule 13D/G filings

Filer	Ownership	Change %	Holdings Value	Net Change	Nb Shares	Change %	Reporting Name	Report Period
BlackRock, Inc.	8%		$411,534,047		5,090,723		BlackRock, Inc.	31 Mar 2025
Pentwater Capital Management LP	6%		$501,345,000		3,900,000		Pentwater Capital Management LP	30 Jun 2025
WELLINGTON MANAGEMENT GROUP LLP	4.8%		$248,446,057		3,073,306		Wellington Management Group LLP	31 Mar 2025
FMR LLC	3.5%		$181,702,331		2,247,679		FMR LLC	31 Dec 2024
PRICE T ROWE ASSOCIATES INC /MD/	2.3%		$188,330,378		1,465,036		T. Rowe Price Associates, Inc.	30 Jun 2025
Avoro Capital Advisors LLC	0.6%	-90%	$48,206,250	-$446,711,250	375,000	-90%	Avoro Capital Advisors LLC	30 Jun 2025

As of 30 Sep 2025, 5 institutional investors reported holding 26,105 shares of Blueprint Medicines Corp - Common Stock, par value $0.001 per share (BPMC). This represents 0.04% of the company’s total 62,500,000 outstanding shares.

Institutional Holders of Blueprint Medicines Corp - Common Stock, par value $0.001 per share (BPMC) across Reporting Periods

Period	Reported Shares, Excl. Options	Value, Excl. Options	Value Change	Puts Notional Value	Calls Notional Value	Price (Median)	Investors
2025 Q3	26,105	$2,576,619	-$8,230,672,915	$0	$0	$128.79	5
2025 Q2	64,312,805	$8,243,642,810	-$126,040,677	$195,692,406	$124,720,586	$128.18	351
2025 Q1	68,514,884	$6,063,967,076	+$140,099,011	$93,236,700	$136,597,483	$88.51	347
2024 Q4	67,119,642	$5,854,543,656	+$179,843,256	$121,325,782	$139,304,544	$87.22	336
2024 Q3	64,715,729	$5,987,635,020	-$229,310,672	$109,095,055	$208,023,655	$92.50	318
2024 Q2	66,173,326	$7,132,550,114	+$112,111,373	$60,184,352	$106,336,116	$107.78	306
2024 Q1	65,243,163	$6,189,368,488	+$140,280,332	$65,519,468	$67,284,244	$94.86	282
2023 Q4	241,820	$22,283,138	-$579,324			$92.24	4
2023 Q3	63,829,566	$3,205,564,423	+$13,391,107	$22,332,834	$7,859,430	$50.22	213
2023 Q2	62,722,556	$3,964,137,610	+$29,036,179	$24,496,320	$9,435,760	$63.20	212
2023 Q1	63,260,190	$2,843,407,947	+$37,372,421	$15,138,700	$6,492,057	$44.99	210
2022 Q4	62,572,749	$2,741,309,168	-$85,250,123	$9,817,675	$5,690,919	$43.81	215
2022 Q3	60,965,518	$4,017,007,301	-$118,706,514	$8,527,000	$14,884,000	$65.89	216
2022 Q2	53,806,056	$2,717,801,258	-$14,225,775	$9,625,600	$23,462,480	$50.51	211
2022 Q1	59,191,549	$3,781,597,801	-$42,945,711	$6,567,000	$11,294,000	$63.88	224
2021 Q4	58,550,493	$6,272,627,662	-$36,015,143	$9,951,000	$6,309,000	$107.11	263
2021 Q3	59,500,744	$6,117,273,666	+$225,562,662	$16,936,000	$36,605,000	$102.81	278
2021 Q2	53,837,358	$4,735,461,606	-$33,865,354	$12,790,000	$8,505,000	$87.96	273
2021 Q1	53,890,884	$5,243,803,010	+$94,270,924	$15,955,000	$6,787,000	$97.23	252
2020 Q4	53,169,400	$5,962,973,942	+$30,620,547	$54,239,965	$19,905,405	$112.15	265
2020 Q3	52,774,810	$4,890,213,854	+$119,888,396	$19,302,000	$23,159,000	$92.70	229
2020 Q2	52,397,661	$4,086,326,596	+$187,105,260	$53,002,000	$38,591,000	$78.00	223
2020 Q1	54,445,244	$3,183,368,601	+$193,744,332	$26,216,000	$28,627,000	$58.48	199
2019 Q4	50,666,938	$4,058,806,983	-$62,473,427	$51,638,000	$34,567,000	$80.11	216
2019 Q3	51,313,715	$3,770,063,315	+$141,808,357	$27,905,000	$82,474,000	$73.47	207
2019 Q2	49,524,070	$4,671,369,772	+$407,433,051	$33,082,000	$55,957,000	$94.33	215
2019 Q1	48,495,907	$3,882,020,514	+$226,653,992	$16,779,000	$14,160,000	$80.05	198
2018 Q4	45,518,912	$2,451,092,455	-$76,825,013	$6,022,000	$7,746,000	$53.91	153
2018 Q3	44,776,527	$3,495,089,825	+$28,707,632	$16,456,000	$9,680,000	$78.06	184
2018 Q2	44,315,673	$2,813,088,168	+$189,370,573	$17,114,000	$33,405,000	$63.48	176
2018 Q1	41,175,213	$3,775,655,943	+$86,828,076	$13,754,000	$13,691,000	$91.70	172
2017 Q4	42,735,794	$3,215,582,175	+$300,157,415	$5,550,000	$18,366,000	$75.41	164
2017 Q3	36,265,378	$2,526,591,713	+$48,052,267	$2,627,000	$3,444,000	$69.67	134
2017 Q2	35,556,687	$1,801,655,033	+$85,503,856	$4,256,000	$2,730,000	$50.67	122
2017 Q1	34,688,336	$1,380,190,267	+$409,758,321	$1,708,000	$2,788,000	$39.99	133
2016 Q4	25,998,128	$729,236,893	+$172,243,077	$363,000	$370,000	$28.05	100
2016 Q3	19,141,323	$568,487,585	+$17,146,600	$276,000	$418,000	$29.70	85
2016 Q2	19,506,571	$394,920,156	+$32,945,727		$0	$20.25	81
2016 Q1	17,896,943	$323,004,000	-$4,071,232		$5,957,000	$18.05	71
2015 Q4	17,994,524	$473,980,234	+$22,327,032		$11,477,000	$26.34	74
2015 Q3	22,950,846	$488,859,942	+$12,792,627			$21.34	67
2015 Q2	23,135,999	$610,407,430	+$586,012,654			$26.49	68