| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Helix Holdings II LLC | 23% | $168,952,713 | 17,878,594 | Bihua Chen | 11 Aug 2025 | |||
| BridgeBio Pharma LLC | 18% | $131,152,335 | 13,878,554 | BridgeBio Pharma LLC | 11 Aug 2025 | |||
| Flynn James E | 6.2% | $46,167,465 | 4,885,446 | Deerfield Management Company, L.P. | 11 Aug 2025 | |||
| BC Global Opportunities IX LP | 5.5% | $41,256,309 | 4,365,747 | BC Global Opportunities IX LP | 04 Sep 2025 | |||
| CITADEL ADVISORS LLC | 3.2% | $29,112,489 | 2,538,142 | Kenneth Griffin | 30 Sep 2025 | |||
| Adage Capital Management, L.P. | 1.9% | $17,063,013 | 1,487,621 | Adage Capital Management, L.P. | 30 Sep 2025 | |||
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.1% | $10,151,432 | 885,042 | T. Rowe Price Associates, Inc. | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 22% | 17,878,594 | 14% | $207,034,119 | |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 6.1% | 4,885,446 | 0.87% | $56,573,465 | |
| Omega Fund Management, LLC | 4.1% | 3,289,661 | 17% | $38,094,274 | |
| WELLINGTON MANAGEMENT GROUP LLP | 3.7% | 2,961,263 | 0.01% | $34,291,426 | |
| Alphabet Inc. | 3.5% | 2,823,126 | 1.4% | $32,691,799 | |
| EcoR1 Capital, LLC | 3.5% | 2,823,126 | 1.6% | $32,691,799 | |
| ENAVATE SCIENCES GP, LLC | 3.3% | 2,626,946 | 9.3% | $30,420,035 | |
| CITADEL ADVISORS LLC | 3.2% | 2,538,141 | 0.02% | $29,391,673 | |
| BlackRock, Inc. | 2.5% | 2,048,552 | 0% | $23,722,232 | |
| NOVO HOLDINGS A/S | 2.4% | 1,961,317 | 1.5% | $22,712,051 | |
| Paradigm Biocapital Advisors LP | 2.3% | 1,866,141 | 0.64% | $21,609,913 | |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.8% | 1,487,621 | 0.03% | $17,226,651 | |
| EVENTIDE ASSET MANAGEMENT, LLC | 1.3% | 1,082,362 | 0.2% | $12,414,692 | |
| Laurion Capital Management LP | 1.3% | 1,045,800 | 1.7% | $12,110,364 | |
| Octagon Capital Advisors LP | 1.3% | 1,043,110 | 1.9% | $12,079,214 | |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.1% | 885,042 | 0% | $10,249,000 | |
| VANGUARD GROUP INC | 0.8% | 647,599 | 0% | $7,499,197 | |
| Aisling Capital Management LP | 0.7% | 564,625 | 1.4% | $6,538,358 | |
| GEODE CAPITAL MANAGEMENT, LLC | 0.67% | 541,602 | 0% | $6,274,554 | |
| ADAR1 Capital Management, LLC | 0.62% | 501,228 | 0.58% | $5,804,220 | |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0.57% | 457,414 | 0.77% | $5,296,854 | |
| ARMISTICE CAPITAL, LLC | 0.51% | 412,000 | 0.15% | $4,770,960 | |
| MILLENNIUM MANAGEMENT LLC | 0.46% | 369,563 | 0% | $4,056,288 | |
| Casdin Capital, LLC | 0.35% | 282,312 | 0.27% | $3,269,173 | |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.35% | 279,350 | 0% | $3,234,873 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 56,812,363 | $657,547,712 | +$657,547,687 | 1,158% | 41 |