| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 8.7% | $574,501,727 | 16,484,985 | The Vanguard Group | 30 Jun 2025 | |||
| VIKING GLOBAL INVESTORS LP | 8.2% | -15% | $825,530,932 | -$140,704,733 | 15,893,934 | -15% | VIKING GLOBAL INVESTORS LP | 14 Nov 2025 |
| KKR Genetic Disorder L.P. | 7% | -31% | $436,020,726 | -$197,280,000 | 13,260,971 | -31% | KKR Genetic Disorder L.P. | 12 May 2025 |
| Kumar Neil | 5.4% | $344,145,491 | 10,466,712 | NEIL KUMAR | 31 Dec 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| VANGUARD GROUP INC | 8.7% | 16,832,059 | +2.1% | 0.01% | $874,257,145 |
| VIKING GLOBAL INVESTORS LP | 8.2% | 15,977,849 | -14% | 2.2% | $829,889,477 |
| BlackRock, Inc. | 7.4% | 14,411,203 | +1.1% | 0.01% | $748,517,884 |
| Kohlberg Kravis Roberts & Co. L.P. | 6.8% | 13,260,971 | 0% | 12% | $688,774,834 |
| JANUS HENDERSON GROUP PLC | 4.5% | 8,741,079 | -5.8% | 0.21% | $453,956,601 |
| FARALLON CAPITAL MANAGEMENT LLC | 4.2% | 8,192,000 | +3.7% | 2.4% | $425,492,480 |
| Aisling Capital Management LP | 3.1% | 6,089,611 | +0.35% | 69% | $316,294,395 |
| STATE STREET CORP | 2.9% | 5,606,340 | -4.9% | 0.01% | $291,193,300 |
| Invesco Ltd. | 2% | 3,928,657 | +40% | 0.03% | $204,054,444 |
| GEODE CAPITAL MANAGEMENT, LLC | 2% | 3,909,941 | +6.2% | 0.01% | $203,113,418 |
| Frazier Life Sciences Management, L.P. | 2% | 3,845,457 | +1.2% | 6% | $199,733,037 |
| UBS Group AG | 1.3% | 2,586,422 | -8% | 0.03% | $134,338,759 |
| TWO SIGMA INVESTMENTS, LP | 1.2% | 2,328,941 | -0.43% | 0.19% | $120,965,196 |
| ALLIANCEBERNSTEIN L.P. | 1.2% | 2,328,715 | -5.7% | 0.04% | $120,953,457 |
| D. E. Shaw & Co., Inc. | 1.2% | 2,252,762 | +8.2% | 0.09% | $117,008,458 |
| GOLDMAN SACHS GROUP INC | 1.1% | 2,209,159 | -16% | 0.02% | $114,743,718 |
| Capital Research Global Investors | 1% | 1,933,126 | -52% | 0.02% | $100,406,564 |
| MACQUARIE GROUP LTD | 1% | 1,933,096 | -7.7% | 0.12% | $100,405,000 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.99% | 1,925,198 | +45% | 0.02% | $99,994,784 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0.99% | 1,914,767 | +1.2% | 0.08% | $99,452,998 |
| SC US (TTGP), LTD. | 0.96% | 1,860,364 | 0% | 0.6% | $96,627,306 |
| Laurion Capital Management LP | 0.9% | 1,753,544 | -27% | 12% | $91,079,076 |
| FMR LLC | 0.88% | 1,700,747 | -16% | 0% | $88,336,805 |
| TWO SIGMA ADVISERS, LP | 0.86% | 1,662,755 | -1.3% | 0.17% | $86,363,495 |
| Driehaus Capital Management LLC | 0.86% | 1,662,069 | -1.7% | 0.62% | $86,327,864 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 168,944 | $12,911,062 | -$11,894,619 | 7,649% | 9 |
| 2025 Q3 | 184,960,254 | $9,606,772,497 | -$158,354,676 | 5,194% | 387 |
| 2025 Q2 | 188,818,044 | $8,154,464,813 | +$171,957,147 | 4,318% | 357 |
| 2025 Q1 | 185,173,982 | $6,405,659,795 | +$325,204,584 | 3,457% | 302 |
| 2024 Q4 | 176,660,902 | $4,847,588,352 | +$119,458,488 | 2,744% | 260 |
| 2024 Q3 | 171,443,774 | $4,364,456,677 | -$97,308,884 | 2,546% | 256 |
| 2024 Q2 | 174,823,558 | $4,428,264,206 | +$85,659,512 | 2,533% | 252 |
| 2024 Q1 | 170,429,536 | $5,269,328,955 | +$130,075,277 | 3,092% | 245 |
| 2023 Q4 | 350,754 | $14,281,223 | +$8,118,476 | 4,037% | 3 |
| 2023 Q3 | 160,532,170 | $4,228,630,384 | +$311,467,959 | 2,637% | 216 |
| 2023 Q2 | 148,984,497 | $2,562,058,177 | -$53,835,959 | 1,720% | 194 |
| 2023 Q1 | 152,299,858 | $2,524,898,700 | +$153,216,330 | 1,658% | 208 |
| 2022 Q4 | 144,543,586 | $1,101,392,226 | -$14,635,108 | 762% | 173 |
| 2022 Q3 | 145,168,440 | $1,443,104,342 | +$49,016,089 | 994% | 167 |
| 2022 Q2 | 138,095,961 | $1,253,730,611 | -$25,389,349 | 907.99% | 149 |
| 2022 Q1 | 140,942,218 | $1,430,811,689 | -$30,306,744 | 1,015% | 163 |
| 2021 Q4 | 141,450,137 | $2,358,480,554 | -$120,474,242 | 1,668% | 177 |
| 2021 Q3 | 139,971,233 | $6,561,165,282 | -$164,818,106 | 4,686.93% | 206 |
| 2021 Q2 | 142,537,078 | $8,688,688,164 | +$97,051,829 | 6,095.99% | 196 |
| 2021 Q1 | 141,008,716 | $8,684,417,555 | +$1,240,009,474 | 6,160% | 196 |
| 2020 Q4 | 120,722,579 | $8,584,366,232 | +$180,150,479 | 7,110.99% | 158 |
| 2020 Q3 | 117,771,063 | $4,390,789,630 | +$21,690,562 | 3,752% | 124 |
| 2020 Q2 | 117,243,177 | $3,822,802,476 | +$145,764,061 | 3,260.99% | 113 |
| 2020 Q1 | 112,837,365 | $3,272,259,195 | +$162,723,850 | 2,900% | 92 |
| 2019 Q4 | 99,870,663 | $3,500,465,628 | +$147,814,760 | 3,505% | 83 |
| 2019 Q3 | 103,219,922 | $2,216,104,734 | +$110,359,965 | 2,146.99% | 73 |
| 2019 Q2 | 99,927,998 | $2,695,534,750 | +$2,695,535,120 | 2,697% | 60 |