| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 9.9% | $50,277,776 | 22,647,647 | Point72 Asset Management, L.P. | 17 Oct 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | $20,959,588 | +$20,959,588 | 9,441,256 | RA Capital Management, L.P. | 17 Oct 2025 | ||
| Bain Capital Life Sciences Fund II, L.P. | 6.2% | $13,453,200 | 6,060,000 | BCLS II Equity Opportunities, LP | 17 Oct 2025 | |||
| WASATCH ADVISORS LP | 6.8% | -34% | $10,773,085 | -$5,817,712 | 4,852,741 | -35% | Wasatch Advisors LP | 30 Sep 2025 |
| MORGAN STANLEY | 6.7% | +26% | $7,315,590 | +$1,419,222 | 4,750,383 | +24% | Morgan Stanley | 30 Jun 2025 |
| ORBIMED ADVISORS LLC | 5% | -23% | $7,921,728 | -$2,413,704 | 3,568,346 | -23% | OrbiMed Capital LLC | 30 Sep 2025 |
| BlackRock, Inc. | 2.5% | $2,705,184 | 1,756,613 | BlackRock, Inc. | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 9.9% | 7,098,133 | 0% | 3.2% | $15,757,855 |
| Soleus Capital Management, L.P. | 9.9% | 7,053,942 | +1.1% | 0.84% | $15,659,751 |
| ORBIMED ADVISORS LLC | 7.3% | 5,235,146 | -23% | 0.28% | $11,622,024 |
| MORGAN STANLEY | 7% | 4,972,032 | +4.6% | 0% | $11,037,911 |
| WASATCH ADVISORS LP | 6.8% | 4,852,741 | -35% | 0.06% | $10,773,085 |
| VANGUARD GROUP INC | 4.5% | 3,191,557 | +5.7% | 0% | $7,085,256 |
| BANK OF AMERICA CORP /DE/ | 2.9% | 2,053,162 | +2.2% | 0% | $4,558,019 |
| MILLENNIUM MANAGEMENT LLC | 2.7% | 1,934,225 | +76% | 0% | $4,293,980 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2.7% | 1,897,383 | 0.61% | $4,212,190 | |
| BlackRock, Inc. | 2.2% | 1,595,639 | -13% | 0% | $3,542,318 |
| Bain Capital Life Sciences Investors, LLC | 1.6% | 1,111,910 | 0% | 0.16% | $2,468,440 |
| RENAISSANCE TECHNOLOGIES LLC | 1.3% | 936,950 | -14% | 0% | $2,080,029 |
| TANG CAPITAL MANAGEMENT LLC | 1.3% | 900,000 | 0% | 0.08% | $1,998,000 |
| TWO SIGMA INVESTMENTS, LP | 1.2% | 834,726 | +22% | 0% | $1,853,092 |
| TWO SIGMA ADVISERS, LP | 1.1% | 763,100 | -6% | 0% | $1,694,082 |
| GEODE CAPITAL MANAGEMENT, LLC | 1% | 725,304 | -2.7% | 0% | $1,610,795 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.72% | 515,437 | +265% | 0% | $1,144,270 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0.71% | 503,145 | +14% | 0% | $1,116,982 |
| CITADEL ADVISORS LLC | 0.67% | 481,449 | 0% | $1,068,817 | |
| GOLDMAN SACHS GROUP INC | 0.64% | 459,893 | -48% | 0% | $1,020,962 |
| Shay Capital LLC | 0.59% | 420,000 | 0.17% | $932,400 | |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.49% | 350,606 | +5.6% | 0% | $778,345 |
| DIMENSIONAL FUND ADVISORS LP | 0.49% | 349,289 | -19% | 0% | $775,460 |
| STATE STREET CORP | 0.4% | 287,373 | 0% | 0% | $637,968 |
| Susquehanna Portfolio Strategies, LLC | 0.38% | 272,053 | +114% | 0.01% | $603,958 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 52,538,995 | $116,636,299 | -$3,488,596 | $2.22 | 96 |
| 2025 Q2 | 54,715,914 | $78,242,864 | -$14,672,713 | $1.43 | 102 |
| 2025 Q1 | 64,100,740 | $102,562,453 | -$12,577,773 | $1.60 | 113 |
| 2024 Q4 | 64,400,415 | $231,841,689 | -$9,805,100 | $3.60 | 113 |
| 2024 Q3 | 64,180,724 | $365,858,797 | +$21,073,780 | $5.70 | 121 |
| 2024 Q2 | 60,887,928 | $281,302,488 | +$7,123,709 | $4.62 | 114 |
| 2024 Q1 | 58,176,311 | $475,299,432 | +$91,161,641 | $8.17 | 103 |
| 2023 Q4 | 85,000 | $480,250 | $5.65 | 1 | |
| 2023 Q3 | 34,586,251 | $64,330,383 | +$58,951 | $1.86 | 81 |
| 2023 Q2 | 34,113,513 | $93,827,140 | -$9,383,416 | $2.75 | 93 |
| 2023 Q1 | 37,322,746 | $117,193,106 | -$15,047,983 | $3.14 | 115 |
| 2022 Q4 | 39,112,024 | $230,744,584 | -$9,769,306 | $5.90 | 109 |
| 2022 Q3 | 39,293,405 | $344,572,414 | -$2,387,272 | $8.77 | 109 |
| 2022 Q2 | 38,822,960 | $292,705,242 | -$38,906,919 | $7.54 | 105 |
| 2022 Q1 | 36,525,343 | $885,662,995 | +$12,934,452 | $24.26 | 115 |
| 2021 Q4 | 34,930,540 | $1,123,813,979 | -$4,994,205 | $32.20 | 114 |
| 2021 Q3 | 34,463,769 | $1,541,455,693 | +$108,870,130 | $44.68 | 111 |
| 2021 Q2 | 31,669,684 | $1,199,070,921 | +$211,475,628 | $37.84 | 106 |
| 2021 Q1 | 25,076,254 | $926,007,055 | +$92,329,956 | $36.99 | 82 |
| 2020 Q4 | 22,245,476 | $728,255,975 | +$703,285,064 | $33.13 | 73 |