| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 12% | $37,908,892 | 6,307,636 | JANUS HENDERSON GROUP PLC | 31 Dec 2025 | |||
| 5AM Ventures VI, L.P. | 12% | $11,855,564 | 5,869,091 | Andrew J. Schwab | 09 Sep 2025 | |||
| Coastlands Capital LP | 10% | $21,452,710 | 4,886,722 | Coastlands Capital LP | 10 Sep 2025 | |||
| Polaris Management Co. VII, L.L.C. | 8.4% | $7,943,147 | 3,932,251 | Amir Nashat | 09 Sep 2025 | |||
| Vivo Opportunity Fund Holdings, L.P. | 7.6% | $7,194,822 | 3,561,793 | Vivo Opportunity Fund Holdings, L.P. | 11 Sep 2025 | |||
| FMR LLC | 6.7% | -55% | $9,657,185 | +$375,243 | 3,145,663 | +4% | FMR LLC | 31 Oct 2025 |
| Enavate Sciences GP, LLC | 6% | -26% | $13,729,110 | -$2,890,560 | 3,127,360 | -17% | Enavate Sciences GP, LLC | 19 Dec 2025 |
| Northpond Ventures II, LP | 4.8% | $6,871,409 | 2,238,244 | Michael P. Rubin | 30 Sep 2025 | |||
| AH Bio Fund I, L.P. | 4.5% | $6,524,791 | 2,125,339 | Marc L. Andreessen | 30 Sep 2025 | |||
| HARBOURVEST PARTNERS LLC | 2.7% | -60% | $3,536,015 | 1,271,948 | 0% | HarbourVest Partners L.P. | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| 5AM Venture Management, LLC | 11% | 5,869,091 | +100% | 6.4% | $17,607,273 |
| JANUS HENDERSON GROUP PLC | 9% | 4,640,970 | 0.01% | $13,922,910 | |
| Vivo Capital, LLC | 7.6% | 3,921,568 | 0.95% | $11,764,704 | |
| ENAVATE SCIENCES GP, LLC | 7.3% | 3,785,802 | 0% | 3.5% | $11,357,406 |
| FMR LLC | 5.8% | 3,023,434 | +397% | 0% | $9,070,302 |
| a16z Capital Management, L.L.C. | 4.1% | 2,125,339 | 0% | 0.46% | $6,376,017 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3.8% | 1,960,784 | 0.01% | $5,882,352 | |
| HarbourVest Partners LLC | 2.5% | 1,271,948 | 0% | 1.9% | $3,815,844 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1.3% | 653,594 | 0.28% | $1,960,782 | |
| VANGUARD GROUP INC | 0.61% | 313,506 | -4.7% | 0% | $940,518 |
| Alyeska Investment Group, L.P. | 0.39% | 200,000 | 0% | 0% | $600,000 |
| TWO SIGMA INVESTMENTS, LP | 0.19% | 97,371 | 0% | $292,113 | |
| MILLENNIUM MANAGEMENT LLC | 0.18% | 95,071 | -29% | 0% | $285,213 |
| VICTORY CAPITAL MANAGEMENT INC | 0.16% | 82,790 | -0.33% | 0% | $248,370 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.12% | 60,371 | -20% | 0% | $181,113 |
| STATE STREET CORP | 0.05% | 26,000 | 0% | $78,000 | |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0.05% | 25,000 | 0% | 0% | $75,000 |
| Mariner, LLC | 0.03% | 17,298 | 0% | $51,894 | |
| NORTHERN TRUST CORP | 0.03% | 14,615 | 0% | 0% | $43,845 |
| BlackRock, Inc. | 0.02% | 11,437 | -86% | 0% | $34,311 |
| UBS Group AG | 0.01% | 7,043 | +38% | 0% | $21,129 |
| Tower Research Capital LLC (TRC) | 0.01% | 5,649 | +47% | 0% | $16,947 |
| ROYAL BANK OF CANADA | 0% | 953 | +80% | 0% | $3,000 |
| BANK OF AMERICA CORP /DE/ | 0% | 283 | -57% | 0% | $849 |
| BNP PARIBAS FINANCIAL MARKETS | 0% | 78 | 0% | 0% | $234 |