| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BCLS Fund III Investments, LP | 10% | 0% | $289,290,002 | +$49,824,886 | 3,020,990 | +21% | BCLS Fund III Investments, LP | 30 Sep 2025 |
| Point72 Asset Management, L.P. | 6.2% | -18% | $151,115,887 | +$4,801,311 | 1,578,069 | +3.3% | Point72 Asset Management, L.P. | 30 Sep 2025 |
| BIOTECHNOLOGY VALUE FUND L P | 4.4% | -16% | $113,871,586 | -$21,545,460 | 1,189,165 | -16% | BVF PARTNERS L P/IL | 15 Oct 2025 |
| Vivo Opportunity Fund Holdings, L.P. | 4.6% | -2% | $57,273,023 | +$27,449,059 | 1,175,796 | +92% | Vivo Opportunity Fund Holdings, L.P. | 30 Jun 2025 |
| BlackRock, Inc. | 4.6% | -15% | $111,424,214 | +$5,356,584 | 1,163,607 | +5.1% | BlackRock, Inc. | 30 Sep 2025 |
| Adage Capital Management, L.P. | 5% | -45% | $53,581,000 | +$5,358,100 | 1,100,000 | +11% | Adage Capital Management, L.P. | 30 Jun 2025 |
| Paradigm Biocapital Advisors LP | 3.3% | -38% | $92,041,065 | -$16,034,916 | 961,164 | -15% | Paradigm BioCapital Advisors LP | 30 Sep 2025 |
| Venrock Healthcare Capital Partners III, L.P. | 3.2% | -67% | $42,793,332 | -$30,795,440 | 639,088 | -42% | Venrock Healthcare Capital Partners III, L.P. | 30 Jun 2025 |
| Commodore Capital LP | 2% | -58% | $56,019,600 | -$56,498,400 | 585,000 | -50% | Commodore Capital LP | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 11% | 3,365,523 | 0% | 4% | $322,282,482 |
| Bain Capital Life Sciences Investors, LLC | 9.6% | 3,020,990 | +21% | 19% | $289,290,002 |
| Point72 Asset Management, L.P. | 5% | 1,578,069 | +3.3% | 0.33% | $151,115,887 |
| BVF INC/IL | 4.5% | 1,414,165 | +80% | 5.5% | $135,420,440 |
| Vivo Capital, LLC | 4.2% | 1,311,425 | 0% | 10% | $125,582,058 |
| VANGUARD GROUP INC | 3.9% | 1,230,666 | +27% | 0% | $117,848,576 |
| BlackRock, Inc. | 3.7% | 1,165,453 | +5.2% | 0% | $111,603,779 |
| Darwin Global Management, Ltd. | 3.2% | 997,196 | +30% | 2.6% | $94,992,891 |
| Paradigm Biocapital Advisors LP | 3% | 961,164 | 2.7% | $92,041,065 | |
| VR ADVISER, LLC | 3% | 946,788 | +48% | 5.1% | $90,664,419 |
| FMR LLC | 2.5% | 775,533 | +613% | 0% | $74,265,040 |
| STATE STREET CORP | 2.5% | 772,759 | +226% | 0% | $73,999,402 |
| JANUS HENDERSON GROUP PLC | 2.2% | 682,901 | +9.3% | 0.03% | $65,363,870 |
| CITADEL ADVISORS LLC | 1.9% | 593,993 | +104% | 0.05% | $56,880,769 |
| Commodore Capital LP | 1.9% | 585,000 | -50% | 2.7% | $56,019,600 |
| FARALLON CAPITAL MANAGEMENT LLC | 1.6% | 508,000 | +154% | 0.27% | $48,646,080 |
| FRED ALGER MANAGEMENT, LLC | 1.6% | 502,877 | 0.19% | $48,155,502 | |
| Soleus Capital Management, L.P. | 1.6% | 493,811 | +6.7% | 2.5% | $47,287,341 |
| Holocene Advisors, LP | 1.5% | 487,233 | 0.11% | $46,657,432 | |
| UBS Group AG | 1.5% | 473,554 | +166% | 0.01% | $45,347,531 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.4% | 450,000 | -59% | 0.07% | $43,092,000 |
| MAVERICK CAPITAL LTD | 1.3% | 417,550 | 0.54% | $39,984,588 | |
| GEODE CAPITAL MANAGEMENT, LLC | 1.3% | 404,114 | +8.6% | 0% | $38,706,733 |
| Vestal Point Capital, LP | 1.3% | 400,000 | -20% | 1.7% | $38,304,000 |
| JENNISON ASSOCIATES LLC | 1.3% | 396,015 | +705% | 0.02% | $37,922,396 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 5,372 | $1,186,403 | +$820,608 | 22,089.11% | 3 |
| 2025 Q3 | 32,486,735 | $3,110,319,924 | +$679,671,203 | 9,576% | 167 |
| 2025 Q2 | 25,911,048 | $1,262,611,204 | +$803,273,239 | 4,871% | 106 |
| 2025 Q1 | 9,559,359 | $205,909,478 | +$57,592,852 | 2,154% | 45 |
| 2024 Q4 | 6,873,669 | $183,637,032 | +$100,865,297 | 2,688% | 40 |
| 2024 Q3 | 3,308,428 | $35,565,026 | +$20,361,777 | 1,075% | 27 |
| 2024 Q2 | 1,412,361 | $16,863,937 | +$16,863,732 | 1,194% | 25 |