| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 10% | +1.9% | $60,117,785 | +$12,881,057 | 17,176,510 | +27% | TANG CAPITAL MANAGEMENT, LLC | 30 Sep 2025 |
| ORBIMED ADVISORS LLC | 8.9% | -19% | $49,921,580 | 15,219,994 | 0% | ORBIMED ADVISORS LLC | 13 Aug 2025 | |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 8.2% | +60% | $46,251,802 | +$22,801,464 | 14,101,159 | +97% | Suvretta Capital Management, LLC | 13 Aug 2025 |
| Vivo Opportunity Fund Holdings, L.P. | 5.1% | $31,485,926 | 8,995,979 | Vivo Opportunity Fund Holdings, L.P. | 30 Sep 2025 | |||
| BIOTECHNOLOGY VALUE FUND L P | 5.1% | $30,625,000 | 8,750,000 | BVF PARTNERS L P/IL | 22 Oct 2025 | |||
| Commander Aggregator, LP | 4.5% | $25,545,132 | 7,788,150 | Commander Aggregator, LP | 14 Aug 2025 | |||
| BlackRock, Inc. | 4.6% | -8% | $12,797,976 | -$977,254 | 6,398,988 | -7.1% | BlackRock, Inc. | 30 Jun 2025 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4.4% | $10,191,177 | 5,994,810 | Adage Capital Management, L.P. | 31 Dec 2024 | |||
| MPM BioImpact LLC | 4.1% | -35% | $14,618,513 | -$7,658,017 | 5,622,505 | -34% | MPM BioImpact LLC | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 9.5% | 16,811,963 | +25% | 2.3% | $58,841,871 |
| ORBIMED ADVISORS LLC | 8.6% | 15,219,994 | 0% | 1.3% | $53,269,979 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 8% | 14,101,159 | +97% | 1.5% | $49,354,057 |
| Blackstone Inc. | 5.6% | 9,840,108 | -1.8% | 0.15% | $34,440,379 |
| Vivo Capital, LLC | 5.4% | 9,545,466 | +58% | 2.7% | $33,409,131 |
| ENAVATE SCIENCES GP, LLC | 4.4% | 7,788,150 | 0% | 8.3% | $27,258,525 |
| BlackRock, Inc. | 4.2% | 7,370,747 | +15% | 0% | $25,797,616 |
| VANGUARD GROUP INC | 4% | 7,062,799 | +46% | 0% | $24,719,798 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2.9% | 5,186,500 | +17% | 0.03% | $18,152,750 |
| MPM BIOIMPACT LLC | 2.9% | 5,075,970 | -9.7% | 2.9% | $17,765,895 |
| BVF INC/IL | 2.7% | 4,750,000 | 0.67% | $16,625,000 | |
| Rock Springs Capital Management LP | 2.5% | 4,474,702 | -9.8% | 0.92% | $15,661,457 |
| FMR LLC | 2.3% | 4,137,562 | +0.07% | 0% | $14,481,467 |
| MILLENNIUM MANAGEMENT LLC | 1.8% | 3,237,572 | +280% | 0.01% | $11,331,502 |
| STATE STREET CORP | 1.8% | 3,106,513 | +58% | 0% | $10,872,796 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.7% | 2,944,469 | +27% | 0% | $10,307,859 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1.6% | 2,833,988 | +127% | 1.4% | $9,918,958 |
| Balyasny Asset Management L.P. | 1.6% | 2,826,362 | 0.02% | $9,892,267 | |
| Blue Owl Capital Holdings LP | 1.5% | 2,591,525 | 0% | 2.8% | $9,070,338 |
| RTW INVESTMENTS, LP | 1.4% | 2,500,000 | 0.11% | $8,750,000 | |
| Logos Global Management LP | 1.2% | 2,050,000 | 0.71% | $7,175,000 | |
| Sofinnova Investments, Inc. | 1.2% | 2,028,886 | 0.44% | $7,101,101 | |
| JPMORGAN CHASE & CO | 1.1% | 1,999,278 | -5.9% | 0% | $6,997,474 |
| ROYAL BANK OF CANADA | 0.96% | 1,700,927 | +1025% | 0% | $5,953,000 |
| Monashee Investment Management LLC | 0.71% | 1,250,000 | +658% | 2.2% | $4,375,000 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 106,562 | $572,156 | -$229,538 | 537.43% | 2 |
| 2025 Q3 | 151,052,849 | $528,694,287 | +$149,920,660 | 350% | 124 |
| 2025 Q2 | 108,253,035 | $281,458,749 | +$738,244 | 260% | 103 |
| 2025 Q1 | 108,444,414 | $206,048,165 | +$13,824,950 | 190% | 107 |
| 2024 Q4 | 101,374,021 | $146,995,622 | +$1,180,772 | 145% | 92 |
| 2024 Q3 | 92,186,861 | $169,597,428 | +$881,084 | 184% | 79 |
| 2024 Q2 | 92,861,661 | $93,412,701 | -$5,271,745 | 100% | 81 |
| 2024 Q1 | 94,552,324 | $187,180,098 | +$18,216,230 | 198% | 77 |
| 2023 Q4 | 39,556 | $61,707 | 156% | 1 | |
| 2023 Q3 | 89,720,729 | $176,713,174 | -$1,697,932 | 197% | 76 |
| 2023 Q2 | 90,478,972 | $287,651,572 | +$28,650,120 | 318% | 72 |
| 2023 Q1 | 81,516,748 | $266,518,963 | +$1,801,941 | 327% | 72 |
| 2022 Q4 | 79,833,267 | $401,391,571 | +$78,794,072 | 503% | 54 |
| 2022 Q3 | 63,858,418 | $145,631,000 | +$8,154,660 | 228% | 36 |
| 2022 Q2 | 61,892,616 | $163,922,000 | +$665,885 | 265% | 31 |
| 2022 Q1 | 62,376,106 | $85,353,000 | -$4,074,808 | 137% | 33 |
| 2021 Q4 | 63,567,962 | $201,611,000 | +$198,091,738 | 317% | 37 |