| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 12% | -11% | $28,475,581 | 9,785,423 | 0% | ORBIMED ADVISORS LLC | 12 May 2025 | |
| MILLER RICHARD A MD | 7.7% | $15,191,271 | 5,220,368 | Richard A. Miller | 31 Dec 2024 | |||
| BlackRock, Inc. | 5.4% | $29,594,309 | 4,015,510 | BlackRock, Inc. | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 9.6% | 7,165,006 | 0% | 1.3% | $52,806,094 |
| Point72 Asset Management, L.P. | 8.7% | 6,454,274 | -8.4% | 0.1% | $47,567,999 |
| BlackRock, Inc. | 6.3% | 4,710,442 | +11% | 0% | $34,715,958 |
| VANGUARD GROUP INC | 4.7% | 3,471,925 | +5.8% | 0% | $25,588,088 |
| ADAMS STREET PARTNERS LLC | 4.4% | 3,275,616 | 0% | 16% | $24,141,290 |
| RTW INVESTMENTS, LP | 3.6% | 2,679,479 | 0% | 0.24% | $19,747,760 |
| Vivo Capital, LLC | 3% | 2,234,566 | 0% | 1.3% | $16,468,751 |
| Foresite Capital Management VI LLC | 2.3% | 1,731,233 | 0% | 4.9% | $12,759,187 |
| GEODE CAPITAL MANAGEMENT, LLC | 2% | 1,456,528 | +7% | 0% | $10,736,839 |
| PERCEPTIVE ADVISORS LLC | 1.9% | 1,438,595 | 0% | 0.31% | $10,602,445 |
| STATE STREET CORP | 1.4% | 1,006,319 | +51% | 0% | $7,416,571 |
| MORGAN STANLEY | 0.83% | 617,224 | -31% | 0% | $4,548,941 |
| NORTHERN TRUST CORP | 0.63% | 466,486 | +16% | 0% | $3,438,001 |
| GOLDMAN SACHS GROUP INC | 0.6% | 445,670 | +162% | 0% | $3,284,588 |
| SPHERA FUNDS MANAGEMENT LTD. | 0.55% | 407,709 | +123% | 0.71% | $3,004,815 |
| GSA CAPITAL PARTNERS LLP | 0.54% | 401,407 | +26% | 0.25% | $2,958,000 |
| BARCLAYS PLC | 0.42% | 309,152 | -10% | 0% | $2,278,448 |
| TWO SIGMA INVESTMENTS, LP | 0.27% | 203,360 | -9.2% | 0% | $1,498,763 |
| WELLINGTON MANAGEMENT GROUP LLP | 0.24% | 180,175 | +76% | 0% | $1,327,889 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.24% | 177,788 | +9.9% | 0% | $1,310,298 |
| TOWERVIEW LLC | 0.23% | 170,000 | 0% | 0.91% | $1,252,900 |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 0.23% | 169,200 | +0.71% | 0.03% | $1,247,004 |
| UBS Group AG | 0.22% | 162,074 | +81% | 0% | $1,194,485 |
| TWO SIGMA ADVISERS, LP | 0.22% | 161,600 | -24% | 0% | $1,190,992 |
| BANK OF AMERICA CORP /DE/ | 0.2% | 151,966 | +14% | 0% | $1,119,989 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 20,164 | $155,101 | +$154,377 | $7.70 | 2 |
| 2025 Q3 | 41,673,686 | $307,002,895 | +$4,353,875 | $7.37 | 101 |
| 2025 Q2 | 41,781,497 | $167,123,225 | +$27,178,676 | $4.00 | 92 |
| 2025 Q1 | 36,268,523 | $115,333,082 | -$7,370,971 | $3.18 | 87 |
| 2024 Q4 | 37,671,901 | $201,543,130 | +$34,430,538 | $5.35 | 85 |
| 2024 Q3 | 30,026,264 | $158,538,176 | +$12,733,378 | $5.28 | 64 |
| 2024 Q2 | 27,591,708 | $50,216,835 | +$17,655,350 | $1.82 | 46 |
| 2024 Q1 | 17,899,766 | $31,860,771 | -$2,307,354 | $1.78 | 47 |
| 2023 Q4 | 19,183,314 | $33,762,501 | -$27,312 | $1.76 | 46 |
| 2023 Q3 | 19,186,334 | $28,011,450 | -$1,230,963 | $1.46 | 52 |
| 2023 Q2 | 19,491,995 | $44,633,999 | +$735,026 | $2.29 | 51 |
| 2023 Q1 | 20,767,710 | $18,897,208 | -$163,899 | $0.91 | 35 |
| 2022 Q4 | 21,339,925 | $18,137,963 | -$596,815 | $0.85 | 37 |
| 2022 Q3 | 22,045,962 | $18,043,081 | -$3,296,252 | $0.82 | 36 |
| 2022 Q2 | 25,545,319 | $25,290,212 | -$3,287,602 | $0.99 | 37 |
| 2022 Q1 | 27,372,071 | $44,888,000 | -$1,208,549 | $1.64 | 49 |
| 2021 Q4 | 27,678,421 | $66,701,000 | -$7,830,824 | $2.41 | 58 |
| 2021 Q3 | 28,180,541 | $136,389,000 | +$22,763,799 | $4.84 | 56 |
| 2021 Q2 | 23,673,230 | $63,207,000 | +$8,569,511 | $2.67 | 44 |
| 2021 Q1 | 20,394,379 | $62,810,000 | +$12,095,864 | $3.08 | 47 |
| 2020 Q4 | 16,311,910 | $58,071,014 | -$3,250,968 | $3.56 | 34 |
| 2020 Q3 | 16,610,724 | $66,606,016 | -$11,812,621 | $4.01 | 32 |
| 2020 Q2 | 20,440,072 | $55,596,011 | -$392,226 | $2.72 | 33 |
| 2020 Q1 | 20,651,240 | $43,573,167 | -$3,308,940 | $2.11 | 36 |
| 2019 Q4 | 20,779,789 | $113,038,430 | -$10,373,883 | $5.44 | 35 |
| 2019 Q3 | 22,891,685 | $68,903,436 | -$4,060,897 | $3.01 | 34 |
| 2019 Q2 | 24,342,578 | $90,952,754 | -$1,478,177 | $3.74 | 43 |
| 2019 Q1 | 24,576,032 | $98,778,635 | -$918,364 | $4.02 | 55 |
| 2018 Q4 | 25,129,562 | $92,162,767 | -$2,053,007 | $3.67 | 59 |
| 2018 Q3 | 25,454,371 | $218,398,586 | -$3,359,100 | $8.58 | 57 |
| 2018 Q2 | 25,906,783 | $284,453,314 | +$902,957 | $10.98 | 55 |
| 2018 Q1 | 25,285,471 | $287,757,705 | +$90,628,274 | $11.53 | 53 |
| 2017 Q4 | 16,748,990 | $173,521,571 | -$6,130,860 | $10.36 | 52 |
| 2017 Q3 | 17,541,888 | $279,680,086 | +$1,086,255 | $15.94 | 51 |
| 2017 Q2 | 17,495,646 | $211,696,598 | -$2,854,069 | $12.10 | 47 |
| 2017 Q1 | 17,335,240 | $360,050,125 | +$9,744,519 | $20.77 | 52 |
| 2016 Q4 | 17,484,501 | $250,048,615 | +$17,391,580 | $14.30 | 53 |
| 2016 Q3 | 16,266,787 | $267,555,203 | -$17,040,529 | $16.45 | 44 |
| 2016 Q2 | 14,645,573 | $208,464,147 | +$14,498,682 | $14.26 | 43 |
| 2016 Q1 | 13,758,120 | $198,361,725 | +$196,693,691 | $14.50 | 31 |