| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 15% | +46% | $468,126,802 | +$145,081,664 | 13,957,269 | +45% | FMR LLC | 31 Mar 2025 |
| VANGUARD GROUP INC | 10% | +2% | $312,311,064 | +$7,452,890 | 9,311,600 | +2.4% | The Vanguard Group | 31 Mar 2025 |
| WELLINGTON MANAGEMENT GROUP LLP | 8.9% | +45% | $349,109,925 | +$107,235,547 | 8,381,991 | +44% | Wellington Management Group LLP | 30 Sep 2025 |
| Farallon Capital Partners, L.P. | 6% | $165,377,881 | 5,625,098 | Dapice Joshua J. | 29 Aug 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 15% | 14,187,498 | +0.44% | 0.03% | $590,909,308 |
| VANGUARD GROUP INC | 9.7% | 9,170,129 | -0.93% | 0.01% | $381,935,873 |
| WELLINGTON MANAGEMENT GROUP LLP | 8.9% | 8,381,991 | +44% | 0.06% | $349,109,926 |
| BlackRock, Inc. | 8.1% | 7,586,597 | +2.3% | 0.01% | $315,981,777 |
| Driehaus Capital Management LLC | 6.9% | 6,481,613 | +1.3% | 1.9% | $269,959,181 |
| FARALLON CAPITAL MANAGEMENT LLC | 6.1% | 5,770,098 | +24% | 1.4% | $240,324,582 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5.6% | 5,306,248 | -5.1% | 0.02% | $221,006,000 |
| EcoR1 Capital, LLC | 4.6% | 4,288,120 | 0% | 8.6% | $178,600,198 |
| JANUS HENDERSON GROUP PLC | 4.1% | 3,858,791 | +13% | 0.07% | $160,695,917 |
| Paradigm Biocapital Advisors LP | 2.7% | 2,550,774 | +8.8% | 3.1% | $106,239,737 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.4% | 2,278,830 | +3% | 0.01% | $94,926,353 |
| STATE STREET CORP | 2.3% | 2,207,707 | -32% | 0% | $91,950,997 |
| JENNISON ASSOCIATES LLC | 2.2% | 2,044,734 | +2.9% | 0.05% | $85,163,170 |
| Point72 Asset Management, L.P. | 2.1% | 2,003,333 | +0.26% | 0.18% | $83,438,803 |
| Siren, L.L.C. | 1.8% | 1,688,611 | 0% | 2.8% | $70,330,648 |
| NOVO HOLDINGS A/S | 1.7% | 1,625,000 | +4.8% | 4.4% | $67,681,250 |
| Pictet Asset Management Holding SA | 1.6% | 1,465,262 | +22% | 0.06% | $61,028,162 |
| JPMORGAN CHASE & CO | 1.3% | 1,258,722 | +279% | 0% | $52,425,771 |
| AMERICAN CENTURY COMPANIES INC | 1.2% | 1,133,535 | +34% | 0.02% | $47,211,782 |
| ORBIMED ADVISORS LLC | 1.2% | 1,099,000 | -4.4% | 1.1% | $45,773,350 |
| First Light Asset Management, LLC | 1% | 941,516 | +9% | 3.7% | $39,214,141 |
| CITADEL ADVISORS LLC | 0.94% | 884,507 | +35% | 0.03% | $36,839,717 |
| Hood River Capital Management LLC | 0.94% | 883,004 | -0.62% | 0.43% | $36,777,117 |
| RTW INVESTMENTS, LP | 0.93% | 872,387 | +87% | 0.45% | $36,334,919 |
| GW&K Investment Management, LLC | 0.9% | 850,546 | -12% | 0.31% | $35,425,000 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 29,620 | $1,378,822 | -$1,544,582 | 4,655.22% | 7 |
| 2025 Q3 | 107,699,166 | $4,485,877,349 | +$149,678,944 | 4,165% | 223 |
| 2025 Q2 | 104,559,713 | $3,007,383,972 | +$75,026,428 | 2,876% | 220 |
| 2025 Q1 | 101,790,251 | $3,418,300,735 | +$9,854,245 | 3,354% | 224 |
| 2024 Q4 | 99,674,221 | $5,096,189,681 | +$758,216,412 | 5,113% | 244 |
| 2024 Q3 | 84,507,337 | $4,321,028,203 | +$33,462,820 | 5,110% | 232 |
| 2024 Q2 | 82,467,822 | $3,693,699,265 | +$92,226,194 | 4,479% | 232 |
| 2024 Q1 | 80,359,899 | $3,761,530,071 | +$489,176,945 | 4,681% | 202 |
| 2023 Q4 | 80,689 | $2,870,914 | -$1,386,175 | 3,558% | 2 |
| 2023 Q3 | 68,511,875 | $2,037,425,662 | +$442,722,141 | 2,974% | 169 |
| 2023 Q2 | 53,863,376 | $970,580,866 | -$14,285,261 | 1,802% | 136 |
| 2023 Q1 | 55,022,720 | $883,667,022 | +$108,684 | 1,606% | 126 |
| 2022 Q4 | 54,774,480 | $1,002,337,337 | -$29,154,494 | 1,830% | 118 |
| 2022 Q3 | 51,383,891 | $1,009,393,441 | +$12,479,930 | 1,963.99% | 113 |
| 2022 Q2 | 50,481,358 | $941,464,132 | +$94,025,834 | 1,865% | 106 |
| 2022 Q1 | 45,457,476 | $996,878,431 | +$24,817,290 | 2,195% | 111 |
| 2021 Q4 | 44,253,023 | $1,255,973,441 | +$251,348,520 | 2,841.01% | 112 |
| 2021 Q3 | 33,618,331 | $707,848,662 | +$17,128,111 | 2,105% | 91 |
| 2021 Q2 | 32,726,927 | $616,934,642 | +$43,330,866 | 1,884.98% | 81 |
| 2021 Q1 | 30,663,471 | $464,249,247 | +$5,703,309 | 1,528% | 77 |
| 2020 Q4 | 30,426,213 | $429,299,885 | -$4,585,138 | 1,411% | 84 |
| 2020 Q3 | 30,337,604 | $475,397,972 | -$19,900,631 | 1,567% | 70 |
| 2020 Q2 | 31,442,275 | $545,926,663 | +$188,615,966 | 1,751.99% | 78 |
| 2020 Q1 | 20,679,259 | $303,859,789 | +$45,414,739 | 1,470.01% | 54 |
| 2019 Q4 | 17,522,474 | $439,633,847 | -$5,476,517 | 2,509% | 57 |
| 2019 Q3 | 15,234,699 | $229,128,583 | -$94,249,206 | 1,503.97% | 60 |
| 2019 Q2 | 15,309,756 | $382,744,098 | +$30,946,837 | 2,500% | 61 |
| 2019 Q1 | 17,728,104 | $403,489,060 | +$21,013,334 | 2,275.92% | 61 |
| 2018 Q4 | 16,774,198 | $503,053,000 | +$19,132,463 | 2,998.97% | 48 |
| 2018 Q3 | 16,164,854 | $463,123,000 | +$463,123,123 | 2,865% | 48 |