| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 7.2% | $133,230,747 | 10,490,610 | BlackRock, Inc. | 31 Mar 2025 | |||
| FMR LLC | 5.8% | $123,948,417 | 8,536,392 | FMR LLC | 30 Sep 2025 | |||
| WELLINGTON MANAGEMENT GROUP LLP | 3.9% | $79,249,615 | 5,664,733 | Wellington Management Group LLP | 30 Jun 2025 | |||
| Capital Research Global Investors | 3.8% | $69,560,580 | 5,477,211 | Capital Research Global Investors | 31 Dec 2024 | |||
| BAILLIE GIFFORD & CO | 5.6% | -23% | $36,149,768 | -$8,897,509 | 2,198,891 | -20% | BAILLIE GIFFORD & CO | 30 Jun 2025 |
As of 30 Sep 2025, 235 institutional investors reported holding 135,496,666 shares of Denali Therapeutics Inc. - COMMON STOCK (DNLI). This represents 92% of the company’s total 147,179,178 outstanding shares.
The largest institutional shareholders of Denali Therapeutics Inc. - COMMON STOCK (DNLI) together control 74% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| BlackRock, Inc. | 8.4% | 12,289,626 | +2% | 0% | $178,445,369 |
| VANGUARD GROUP INC | 8.1% | 11,992,918 | +1.5% | 0% | $174,137,169 |
| BAILLIE GIFFORD & CO | 7.9% | 11,591,585 | -3% | 0.12% | $168,309,813 |
| FMR LLC | 4.3% | 6,340,316 | -16% | 0% | $92,061,393 |
| T. Rowe Price Investment Management, Inc. | 3.8% | 5,638,567 | +74% | 0.05% | $81,872,000 |
| UBS AM, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS LLC | 3.7% | 5,465,037 | -13% | 0.02% | $79,352,339 |
| STATE STREET CORP | 3.7% | 5,464,261 | +21% | 0% | $79,341,070 |
| Temasek Holdings (Private) Ltd | 3.6% | 5,355,832 | 0% | 0.27% | $77,766,681 |
| Capital Research Global Investors | 3.2% | 4,760,858 | +0.22% | 0.01% | $69,127,658 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.1% | 4,568,368 | -31% | 0.01% | $66,333,000 |
| BAKER BROS. ADVISORS LP | 2.5% | 3,731,695 | 0% | 0.39% | $54,184,211 |
| ALLIANCEBERNSTEIN L.P. | 2.4% | 3,520,414 | +12% | 0.02% | $51,116,411 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.4% | 3,466,057 | +9.3% | 0% | $50,335,167 |
| Crestline Management, LP | 2.3% | 3,410,732 | -12% | 85% | $49,523,829 |
| Holocene Advisors, LP | 2.1% | 3,135,712 | +678% | 0.1% | $45,530,538 |
| Point72 Asset Management, L.P. | 1.7% | 2,519,535 | +14% | 0.08% | $36,583,650 |
| DIMENSIONAL FUND ADVISORS LP | 1.6% | 2,357,214 | -2.3% | 0.01% | $34,226,491 |
| GOLDMAN SACHS GROUP INC | 1.5% | 2,163,705 | +16% | 0% | $31,416,997 |
| UBS Group AG | 1.4% | 2,012,353 | +112% | 0.01% | $29,219,365 |
| STEMPOINT CAPITAL LP | 1.2% | 1,734,659 | +145% | 5.1% | $25,187,249 |
| MORGAN STANLEY | 1.1% | 1,689,492 | +29% | 0% | $24,531,439 |
| Fisher Asset Management, LLC | 1.1% | 1,631,496 | +7.6% | 0.01% | $23,689,321 |
| MILLENNIUM MANAGEMENT LLC | 0.89% | 1,307,171 | +45% | 0.01% | $18,980,123 |
| PRINCIPAL FINANCIAL GROUP INC | 0.86% | 1,271,190 | +18% | 0.01% | $18,457,679 |
| NORTHERN TRUST CORP | 0.84% | 1,234,179 | +2.7% | 0% | $17,920,279 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 2,675,442 | $44,171,785 | +$17,587,936 | $16.51 | 20 |
| 2025 Q3 | 135,496,666 | $1,967,413,087 | -$29,612,977 | $14.52 | 235 |
| 2025 Q2 | 137,594,175 | $1,925,023,022 | +$63,128,644 | $13.99 | 228 |
| 2025 Q1 | 132,874,634 | $1,807,534,840 | +$50,388,755 | $13.60 | 219 |
| 2024 Q4 | 127,918,322 | $2,606,945,002 | +$19,549,827 | $20.38 | 221 |
| 2024 Q3 | 126,357,167 | $3,680,165,886 | +$76,196,259 | $29.13 | 215 |
| 2024 Q2 | 119,614,175 | $2,777,409,220 | +$110,937,376 | $23.22 | 202 |
| 2024 Q1 | 121,129,498 | $2,485,853,165 | +$124,876,915 | $20.52 | 208 |
| 2023 Q4 | 4,670,024 | $96,733,812 | -$3,645,391 | $21.46 | 4 |
| 2023 Q3 | 107,839,117 | $2,224,760,143 | +$10,695,553 | $20.63 | 191 |
| 2023 Q2 | 106,694,834 | $3,148,558,535 | -$754,311 | $29.51 | 195 |
| 2023 Q1 | 107,882,145 | $2,484,889,935 | +$45,523,771 | $23.04 | 195 |
| 2022 Q4 | 105,756,695 | $2,941,077,381 | +$354,688,172 | $27.81 | 190 |
| 2022 Q3 | 91,624,821 | $2,811,570,719 | -$38,245,613 | $30.69 | 187 |
| 2022 Q2 | 92,157,220 | $2,712,102,127 | +$189,300,850 | $29.43 | 172 |
| 2022 Q1 | 86,541,948 | $2,784,525,759 | +$41,733,879 | $32.17 | 172 |
| 2021 Q4 | 85,195,627 | $3,799,942,368 | +$12,226,688 | $44.60 | 201 |
| 2021 Q3 | 84,789,652 | $4,278,426,976 | +$169,776,157 | $50.45 | 206 |
| 2021 Q2 | 77,750,105 | $6,097,458,707 | +$33,999,316 | $78.44 | 205 |
| 2021 Q1 | 77,712,457 | $4,436,868,770 | +$73,562,778 | $57.10 | 211 |
| 2020 Q4 | 66,014,536 | $5,528,696,915 | +$204,274,299 | $83.76 | 197 |
| 2020 Q3 | 82,543,810 | $2,957,682,334 | +$14,823,264 | $35.83 | 165 |
| 2020 Q2 | 82,625,820 | $1,997,882,520 | +$63,459,910 | $24.18 | 139 |
| 2020 Q1 | 80,140,725 | $1,403,267,222 | +$148,038,169 | $17.51 | 123 |
| 2019 Q4 | 70,718,085 | $1,231,893,094 | -$9,090,266 | $17.42 | 106 |
| 2019 Q3 | 71,153,301 | $1,090,104,879 | -$4,834,646 | $15.32 | 110 |
| 2019 Q2 | 71,323,010 | $1,480,644,493 | +$62,486,957 | $20.76 | 111 |
| 2019 Q1 | 68,854,243 | $1,598,840,118 | +$23,453,607 | $23.22 | 111 |
| 2018 Q4 | 68,033,725 | $1,405,546,161 | -$869,690 | $20.66 | 86 |
| 2018 Q3 | 66,971,326 | $1,455,928,654 | +$108,766,089 | $21.74 | 76 |
| 2018 Q2 | 62,206,479 | $948,642,603 | +$18,838,767 | $15.25 | 66 |
| 2018 Q1 | 60,832,830 | $1,196,651,992 | +$60,184,105 | $19.69 | 56 |
| 2017 Q4 | 58,142,948 | $909,284,000 | +$768,126,565 | $15.64 | 44 |