| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 14% | +16% | $324,265,066 | +$45,337,554 | 4,907,159 | +16% | FMR LLC | 30 Sep 2025 |
| AI DMI LLC | 8% | -25% | $199,459,837 | -$49,166,626 | 3,018,460 | -20% | AI DMI LLC | 20 Oct 2025 |
| RA CAPITAL MANAGEMENT, L.P. | 5.9% | $177,001,530 | 2,228,924 | RA Capital Management, L.P. | 30 Dec 2025 | |||
| ORBIMED ADVISORS LLC | 4.5% | $60,278,171 | 1,556,369 | ORBIMED ADVISORS LLC | 10 Mar 2025 | |||
| WELLINGTON MANAGEMENT GROUP LLP | 4.1% | -39% | $75,843,486 | -$48,268,221 | 1,432,090 | -39% | Wellington Management Group LLP | 30 Jun 2025 |
| Paradigm Biocapital Advisors LP | 3.5% | $46,900,907 | 1,210,971 | Paradigm BioCapital Advisors LP | 31 Mar 2025 | |||
| Frazier Life Sciences Public Fund, L.P. | 3% | $61,332,718 | 1,026,489 | Frazier Life Sciences Public Fund, L.P. | 30 Jun 2025 | |||
| Bain Capital Life Sciences Opportunities III, LP | 3.3% | $38,090,955 | 983,500 | Bain Capital Life Sciences Opportunities III, LP | 31 Dec 2024 | |||
| Atlas Venture Fund X, L.P. | 2.2% | -30% | $73,469,638 | -$24,517,376 | 813,167 | -25% | Atlas Venture Fund X, L.P. | 12 Dec 2025 |
As of 30 Sep 2025, 163 institutional investors reported holding 34,174,570 shares of Disc Medicine, Inc. - Common Stock, $0.0001 par value per share (IRON). This represents 90% of the company’s total 37,778,373 outstanding shares.
The largest institutional shareholders of Disc Medicine, Inc. - Common Stock, $0.0001 par value per share (IRON) together control 72% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 13% | 4,935,159 | +52% | 0.02% | $326,115,306 |
| Atlas Venture Life Science Advisors, LLC | 5.7% | 2,142,617 | -10% | 19% | $141,584,131 |
| BlackRock, Inc. | 5.3% | 2,019,283 | -1.2% | 0% | $133,434,221 |
| RA CAPITAL MANAGEMENT, L.P. | 4.2% | 1,577,106 | 0% | 1.3% | $104,215,164 |
| VANGUARD GROUP INC | 3.8% | 1,448,059 | +3.7% | 0% | $95,687,738 |
| Frazier Life Sciences Management, L.P. | 3.8% | 1,438,534 | -13% | 2.8% | $95,058,327 |
| ORBIMED ADVISORS LLC | 3.7% | 1,415,020 | 0% | 2.2% | $93,504,522 |
| WELLINGTON MANAGEMENT GROUP LLP | 3.7% | 1,410,077 | -1.5% | 0.02% | $93,177,887 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.5% | 1,326,429 | -12% | 0.01% | $87,651,000 |
| STATE STREET CORP | 2.8% | 1,045,597 | +12% | 0% | $69,093,050 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2.4% | 919,403 | 0% | 0.93% | $60,754,150 |
| Siren, L.L.C. | 2.4% | 913,401 | -17% | 2.4% | $60,357,538 |
| Woodline Partners LP | 2.3% | 866,955 | 0% | 0.27% | $57,288,386 |
| JPMORGAN CHASE & CO | 2% | 752,879 | -11% | 0% | $49,750,244 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.7% | 628,151 | +4.9% | 0% | $41,515,834 |
| GOLDMAN SACHS GROUP INC | 1.4% | 529,081 | +134% | 0.01% | $34,961,672 |
| Vestal Point Capital, LP | 1.3% | 500,000 | +257% | 1.5% | $33,040,000 |
| TCG Crossover Management, LLC | 1.2% | 465,257 | 0% | 1.5% | $30,744,183 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.2% | 450,000 | 0% | 0.05% | $29,736,000 |
| Logos Global Management LP | 1.2% | 450,000 | -36% | 2.9% | $29,736,000 |
| ARMISTICE CAPITAL, LLC | 1.2% | 436,000 | 0% | 0.9% | $28,810,880 |
| Checkpoint Capital L.P. | 1.1% | 430,000 | +62% | 9.5% | $28,414,400 |
| First Turn Management, LLC | 1.1% | 397,693 | +33% | 3.9% | $26,279,553 |
| JANUS HENDERSON GROUP PLC | 0.96% | 361,704 | -77% | 0.01% | $23,901,085 |
| Saturn V Capital Management LP | 0.9% | 340,897 | -14% | 4.9% | $22,526,474 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 381,185 | $30,269,604 | +$28,644,909 | $79.41 | 6 |
| 2025 Q3 | 34,174,570 | $2,258,188,278 | +$16,097,599 | $66.08 | 163 |
| 2025 Q2 | 34,069,415 | $1,804,406,782 | +$52,373,232 | $52.96 | 149 |
| 2025 Q1 | 33,154,047 | $1,649,828,928 | +$313,979,405 | $49.64 | 155 |
| 2024 Q4 | 26,576,603 | $1,684,756,125 | -$53,215,202 | $63.40 | 151 |
| 2024 Q3 | 27,309,249 | $1,342,089,364 | -$26,632,926 | $49.14 | 130 |
| 2024 Q2 | 27,576,793 | $1,242,994,010 | +$212,594,232 | $45.07 | 120 |
| 2024 Q1 | 22,155,330 | $1,379,374,904 | +$122,863,170 | $62.26 | 130 |
| 2023 Q4 | 7,884 | $455,379 | +$455,379 | $57.76 | 2 |
| 2023 Q3 | 19,879,804 | $933,956,150 | +$42,877,679 | $46.98 | 89 |
| 2023 Q2 | 19,115,363 | $848,708,619 | +$223,083,556 | $44.40 | 89 |
| 2023 Q1 | 14,612,401 | $309,636,635 | +$67,427,487 | $21.19 | 44 |
| 2022 Q4 | 10,800,003 | $214,638,221 | +$202,495,213 | $19.89 | 30 |