| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 6.3% | -32% | $137,535,714 | -$65,564,381 | 9,356,171 | -32% | Deep Track Capital, LP | 30 Sep 2025 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5.6% | -43% | $121,716,000 | -$93,071,712 | 8,280,000 | -43% | SUVRETTA CAPITAL MANAGEMENT, LLC | 30 Sep 2025 |
| VANGUARD GROUP INC | 5.6% | $71,954,004 | 8,242,154 | The Vanguard Group | 30 Jun 2025 | |||
| JANUS HENDERSON GROUP PLC | 3.6% | -76% | $79,062,546 | -$226,538,863 | 5,378,185 | -74% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| BIOTECHNOLOGY VALUE FUND L P | 3.6% | $31,507,344 | 4,333,885 | BVF PARTNERS L P/IL | 31 Dec 2024 | |||
| RTW INVESTMENTS, LP | 1.3% | $14,303,921 | 1,967,527 | RTW Investments, LP | 31 Mar 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 13% | 19,889,683 | 0% | 3.6% | $292,378,340 |
| Pentwater Capital Management LP | 7.9% | 11,750,000 | 1.6% | $172,725,000 | |
| BlackRock, Inc. | 7% | 10,316,393 | -2.4% | 0% | $151,650,978 |
| Deep Track Capital, LP | 6.3% | 9,356,171 | -1.5% | 3.8% | $137,535,714 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6.1% | 9,097,587 | +362% | 0.21% | $133,734,529 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5.6% | 8,280,000 | -42% | 3.7% | $121,716,000 |
| VANGUARD GROUP INC | 5.4% | 8,053,459 | -2.3% | 0% | $118,385,847 |
| Avoro Capital Advisors LLC | 4.3% | 6,387,790 | -5.4% | 1.2% | $93,900,513 |
| GLAZER CAPITAL, LLC | 3.8% | 5,636,905 | 2.8% | $82,863,000 | |
| JANUS HENDERSON GROUP PLC | 3.6% | 5,378,185 | -74% | 0.04% | $79,055,106 |
| STATE STREET CORP | 3.6% | 5,286,308 | +24% | 0% | $77,708,728 |
| DEUTSCHE BANK AG\ | 2.4% | 3,499,625 | +3942% | 0.02% | $51,444,487 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 2.2% | 3,291,369 | -2.4% | 0.2% | $48,383,124 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.1% | 3,092,340 | -0.61% | 0% | $45,463,604 |
| SYQUANT CAPITAL SAS | 1.7% | 2,593,694 | 11% | $38,127,000 | |
| KRYGER CAPITAL Ltd | 1.6% | 2,350,000 | 4% | $34,545,000 | |
| TIG Advisors, LLC | 1.5% | 2,186,648 | 2% | $32,143,726 | |
| Hudson Bay Capital Management LP | 1.5% | 2,172,000 | +862% | 0.19% | $31,928,400 |
| ADAR1 Capital Management, LLC | 1.4% | 2,113,153 | +141% | 3.1% | $31,063,349 |
| GOLDMAN SACHS GROUP INC | 1.1% | 1,616,785 | +29% | 0% | $23,766,740 |
| DIMENSIONAL FUND ADVISORS LP | 1.1% | 1,606,783 | +36% | 0.01% | $23,619,710 |
| Redmile Group, LLC | 0.99% | 1,473,136 | -4.7% | 2.1% | $21,655,099 |
| Balyasny Asset Management L.P. | 0.98% | 1,459,055 | 0.04% | $21,448,109 | |
| Weiss Asset Management LP | 0.94% | 1,400,000 | 0.31% | $20,580,000 | |
| NORTHERN TRUST CORP | 0.76% | 1,125,784 | -0.59% | 0% | $16,549,026 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 0 | $0 | -$7,041,859 | 0 | |
| 2025 Q3 | 154,682,203 | $2,273,597,098 | -$595,145 | 1,470% | 195 |
| 2025 Q2 | 161,195,505 | $1,583,221,092 | +$87,329,474 | 982% | 181 |
| 2025 Q1 | 154,244,684 | $1,137,978,481 | +$235,722,746 | 727% | 184 |
| 2024 Q4 | 121,178,976 | $947,689,844 | +$128,680,447 | 782% | 152 |
| 2024 Q3 | 104,404,539 | $772,806,031 | +$3,700,267 | 740% | 143 |
| 2024 Q2 | 103,297,380 | $827,333,331 | +$24,697,079 | 801% | 143 |
| 2024 Q1 | 98,362,602 | $1,144,203,781 | +$59,252,054 | 1,164% | 150 |
| 2023 Q4 | 539,470 | $6,043,390 | +$5,107,985 | 1,117% | 3 |
| 2023 Q3 | 71,901,014 | $1,110,190,442 | -$106,567,852 | 1,544% | 157 |
| 2023 Q2 | 77,046,537 | $1,460,096,312 | +$128,162,202 | 1,895% | 156 |
| 2023 Q1 | 70,992,649 | $1,081,023,134 | +$392,829,200 | 1,523% | 146 |
| 2022 Q4 | 46,306,156 | $589,465,858 | +$135,051,607 | 1,273% | 106 |
| 2022 Q3 | 39,078,432 | $226,262,083 | +$45,295,427 | 579% | 82 |
| 2022 Q2 | 32,355,899 | $104,246,000 | +$47,935,230 | 322% | 66 |
| 2022 Q1 | 16,354,371 | $61,653,000 | -$15,174,145 | 376.93% | 64 |
| 2021 Q4 | 17,305,335 | $226,115,000 | -$711,030 | 1,307.04% | 49 |
| 2021 Q3 | 17,322,213 | $339,443,000 | +$9,487,063 | 1,959.01% | 48 |
| 2021 Q2 | 16,626,660 | $310,917,000 | -$3,450,615 | 1,869.93% | 49 |
| 2021 Q1 | 16,578,236 | $392,590,000 | +$6,868,784 | 2,367.94% | 66 |
| 2020 Q4 | 16,716,696 | $407,455,000 | +$14,917,144 | 2,437.05% | 69 |
| 2020 Q3 | 16,031,138 | $411,147,774 | +$141,753,387 | 2,565.99% | 67 |
| 2020 Q2 | 10,412,527 | $207,490,000 | -$1,581,240 | 1,992.93% | 36 |
| 2020 Q1 | 10,699,602 | $270,165,000 | +$7,516,231 | 2,525.01% | 30 |
| 2019 Q4 | 10,258,166 | $269,686,000 | +$267,410,212 | 2,628.92% | 32 |