| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 13% | $158,600,805 | 7,918,163 | ORBIMED ADVISORS LLC | 16 Jun 2025 | |||
| FMR LLC | 13% | $161,103,383 | 7,870,219 | FMR LLC | 30 Sep 2025 | |||
| Commodore Capital LP | 9.9% | $124,554,751 | 6,022,957 | Commodore Capital LP | 30 Jun 2025 | |||
| Fairmount Funds Management LLC | 6.3% | -4.3% | $76,752,662 | +$10,518,799 | 3,711,444 | +16% | Fairmount Funds Management LLC | 30 Jun 2025 |
| Venrock Healthcare Capital Partners III, L.P. | 5.4% | $66,042,996 | 3,226,331 | Venrock Healthcare Capital Partners III, L.P. | 30 Sep 2025 | |||
| BlackRock, Inc. | 5.1% | $58,916,142 | 2,941,395 | BlackRock, Inc. | 30 Jun 2025 | |||
| Polar Capital Holdings Plc | 5.2% | +5.6% | $52,462,699 | +$3,044,365 | 2,536,881 | +6.2% | Polar Capital Holdings Plc | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 13% | 7,959,538 | 0% | 3.9% | $162,931,743 |
| FMR LLC | 12% | 7,129,196 | -5.7% | 0.01% | $145,934,642 |
| Commodore Capital LP | 7.9% | 4,692,809 | 0% | 4.7% | $96,061,800 |
| Fairmount Funds Management LLC | 6.2% | 3,711,444 | 0% | 6.8% | $75,973,259 |
| BlackRock, Inc. | 5.9% | 3,518,524 | +19% | 0% | $72,024,186 |
| VR ADVISER, LLC | 5.4% | 3,226,331 | -20% | 3.7% | $66,042,996 |
| Polar Capital Holdings Plc | 5.2% | 3,095,007 | +1.5% | 0.31% | $63,354,793 |
| VANGUARD GROUP INC | 4.3% | 2,553,014 | +5.9% | 0% | $52,260,198 |
| JANUS HENDERSON GROUP PLC | 3% | 1,793,583 | +4.5% | 0.02% | $36,696,708 |
| NOVO HOLDINGS A/S | 2.4% | 1,426,260 | +32% | 1.9% | $29,195,542 |
| Pictet Asset Management Holding SA | 2.3% | 1,398,087 | +45% | 0.03% | $28,618,841 |
| Blackstone Inc. | 2.2% | 1,320,592 | 0% | 0.12% | $27,032,518 |
| Capital Research Global Investors | 2.2% | 1,315,465 | 0% | 0.01% | $26,927,569 |
| CITADEL ADVISORS LLC | 1.9% | 1,160,503 | -21% | 0.02% | $23,755,496 |
| Vestal Point Capital, LP | 1.9% | 1,160,000 | +364% | 1.1% | $23,745,200 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.8% | 1,085,013 | +23% | 0% | $22,213,256 |
| Point72 Asset Management, L.P. | 1.7% | 1,040,410 | -23% | 0.05% | $21,297,200 |
| STATE STREET CORP | 1.6% | 965,137 | +18% | 0% | $19,756,354 |
| Duquesne Family Office LLC | 1.6% | 947,405 | +105% | 0.49% | $19,393,000 |
| First Turn Management, LLC | 1.3% | 783,411 | +54% | 2.4% | $16,036,423 |
| 5AM Venture Management, LLC | 1.3% | 772,477 | 0% | 5.8% | $15,812,604 |
| Rock Springs Capital Management LP | 1.1% | 686,107 | -2.2% | 0.82% | $14,044,610 |
| Candriam S.C.A. | 1% | 609,352 | +46% | 0.07% | $12,473,435 |
| FRANKLIN RESOURCES INC | 0.72% | 430,240 | 0% | 0% | $8,807,012 |
| Affinity Asset Advisors, LLC | 0.67% | 400,000 | 0% | 0.76% | $8,188,000 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 190 | $2,926 | -$185 | $15.40 | 1 |
| 2025 Q3 | 59,389,507 | $1,215,687,864 | -$296,032 | $20.47 | 132 |
| 2025 Q2 | 59,434,902 | $1,192,251,085 | +$192,194,974 | $20.06 | 123 |
| 2025 Q1 | 49,886,849 | $983,923,862 | +$4,352,399 | $19.68 | 118 |
| 2024 Q4 | 49,624,914 | $1,116,597,640 | +$24,828,964 | $22.50 | 111 |
| 2024 Q3 | 47,688,348 | $1,218,010,526 | -$20,846,844 | $25.54 | 100 |
| 2024 Q2 | 48,320,278 | $1,129,227,408 | +$91,685,963 | $23.37 | 92 |
| 2024 Q1 | 44,456,336 | $780,753,586 | +$95,504,194 | $17.59 | 72 |
| 2023 Q4 | 39,000,634 | $539,791,850 | -$1,283,087 | $13.84 | 61 |
| 2023 Q3 | 39,076,502 | $533,779,622 | -$2,178,660 | $13.66 | 61 |
| 2023 Q2 | 39,092,843 | $797,916,151 | +$112,876,605 | $20.41 | 61 |
| 2023 Q1 | 33,557,749 | $734,910,999 | +$734,910,939 | $21.90 | 44 |