| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 7.7% | $25,059,688 | 1,981,003 | EcoR1 Capital, LLC | 31 Dec 2024 | |||
| BlackRock, Inc. | 5.7% | $25,694,694 | 1,530,357 | BlackRock, Inc. | 30 Jun 2025 | |||
| VANGUARD GROUP INC | 5% | $29,207,619 | 1,344,115 | The Vanguard Group | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Opaleye Management Inc. | 11% | 2,860,000 | 0% | 8.8% | $62,147,800 |
| EcoR1 Capital, LLC | 7.6% | 2,030,544 | 0% | 2.1% | $44,123,721 |
| BlackRock, Inc. | 6.4% | 1,704,361 | +11% | 0% | $37,035,765 |
| VANGUARD GROUP INC | 5% | 1,344,115 | +2.4% | 0% | $29,207,619 |
| Nantahala Capital Management, LLC | 4.4% | 1,175,951 | 0% | 1.6% | $25,553,415 |
| MORGAN STANLEY | 2.2% | 586,046 | +15% | 0% | $12,734,780 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.1% | 574,030 | -3.2% | 0% | $12,476,472 |
| ROYAL BANK OF CANADA | 1.8% | 479,192 | +9363% | 0% | $10,413,000 |
| Westside Investment Management, Inc. | 1.8% | 472,540 | -0.05% | 1.6% | $10,267,577 |
| CANNELL CAPITAL LLC | 1.7% | 455,405 | +17% | 2.6% | $9,895,951 |
| STATE STREET CORP | 1.6% | 438,445 | +36% | 0% | $9,527,410 |
| THOMPSON SIEGEL & WALMSLEY LLC | 1.6% | 418,566 | +9.8% | 0.15% | $9,095,000 |
| JPMORGAN CHASE & CO | 1.3% | 351,417 | +45% | 0% | $7,636,291 |
| RENAISSANCE TECHNOLOGIES LLC | 1.2% | 324,621 | -20% | 0.01% | $7,054,014 |
| Divisadero Street Capital Management, LP | 1.1% | 298,000 | -40% | 0.3% | $6,475,540 |
| TWO SIGMA INVESTMENTS, LP | 1.1% | 286,421 | +33% | 0.01% | $6,223,928 |
| NORTHERN TRUST CORP | 0.91% | 245,051 | -6.5% | 0% | $5,324,958 |
| BNP PARIBAS FINANCIAL MARKETS | 0.86% | 229,790 | 0% | 0% | $4,993,337 |
| UBS Group AG | 0.82% | 220,361 | +3.7% | 0% | $4,788,445 |
| Soleus Capital Management, L.P. | 0.75% | 200,000 | -30% | 0.23% | $4,346,000 |
| OBERWEIS ASSET MANAGEMENT INC/ | 0.72% | 192,360 | 0.16% | $4,179,983 | |
| GOLDMAN SACHS GROUP INC | 0.71% | 190,164 | +74% | 0% | $4,132,263 |
| Lumbard & Kellner, LLC | 0.66% | 176,300 | 1.4% | $3,830,999 | |
| TWO SIGMA ADVISERS, LP | 0.63% | 168,900 | +67% | 0.01% | $3,670,197 |
| Aristides Capital LLC | 0.62% | 167,587 | 0% | 1.1% | $3,641,666 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 6,494 | $109,389 | +$109,389 | 1,687.87% | 2 |
| 2025 Q3 | 17,672,584 | $384,025,414 | +$23,406,415 | 2,173% | 101 |
| 2025 Q2 | 16,549,306 | $235,826,915 | +$35,134,980 | 1,425% | 85 |
| 2025 Q1 | 14,123,114 | $183,315,077 | +$11,955,179 | 1,298% | 85 |
| 2024 Q4 | 13,135,396 | $174,958,469 | +$42,338,288 | 1,332% | 70 |
| 2024 Q3 | 9,507,414 | $57,043,272 | +$8,311,785 | 600% | 48 |
| 2024 Q2 | 8,228,308 | $27,068,977 | +$3,401,842 | 329% | 44 |
| 2024 Q1 | 7,182,688 | $26,933,962 | -$87,279 | 375% | 43 |
| 2023 Q4 | 0 | $0 | -$87,987 | 0 | |
| 2023 Q3 | 6,899,800 | $28,769,681 | +$3,931,368 | 417% | 50 |
| 2023 Q2 | 5,976,427 | $20,857,388 | +$440,318 | 349% | 33 |
| 2023 Q1 | 5,838,481 | $22,478,563 | +$148,360 | 385% | 34 |
| 2022 Q4 | 5,937,571 | $16,707,403 | -$1,027,869 | 281.96% | 31 |
| 2022 Q3 | 6,054,123 | $12,712,785 | +$549,663 | 210% | 28 |
| 2022 Q2 | 5,271,693 | $13,812,917 | -$20,184 | 262.02% | 25 |
| 2022 Q1 | 5,479,743 | $23,886,686 | +$176,962 | 436% | 27 |
| 2021 Q4 | 5,432,030 | $23,304,557 | -$881,069 | 428.99% | 28 |
| 2021 Q3 | 5,962,979 | $32,576,856 | -$4,921,316 | 504.01% | 36 |
| 2021 Q2 | 6,841,117 | $51,783,059 | -$12,976,920 | 616.16% | 43 |
| 2021 Q1 | 8,785,326 | $67,962,804 | +$241,245 | 731.92% | 49 |
| 2020 Q4 | 8,725,390 | $70,936,528 | +$13,606,263 | 813% | 45 |
| 2020 Q3 | 6,459,891 | $51,033,819 | +$510,955 | 789.86% | 34 |
| 2020 Q2 | 6,803,798 | $37,079,733 | +$4,606,421 | 544.86% | 40 |
| 2020 Q1 | 5,967,575 | $24,469,000 | +$13,632,158 | 410.16% | 17 |
| 2019 Q4 | 2,623,150 | $18,886,000 | +$2,666,855 | 719.86% | 13 |
| 2019 Q3 | 2,276,530 | $14,386,000 | +$3,212,366 | 631.58% | 13 |
| 2019 Q2 | 1,767,833 | $13,965,000 | +$2,101,439 | 789.77% | 10 |
| 2019 Q1 | 1,501,083 | $12,008,000 | +$2,816,107 | 800% | 12 |
| 2018 Q4 | 1,151,824 | $7,048,000 | +$7,047,972 | 612% | 11 |