| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 10% | $121,826,100 | 8,265,000 | Cormorant Asset Management, LP | 04 Dec 2025 | |||
| Adage Capital Management, L.P. | 8.1% | -18% | $79,171,296 | -$17,660,704 | 5,559,782 | -18% | Adage Capital Management, L.P. | 30 Sep 2025 |
| FEDERATED HERMES, INC. | 6.7% | $27,182,750 | 4,599,450 | Federated Hermes, Inc. | 30 Jun 2025 | |||
| BlackRock, Inc. | 6.5% | $63,872,124 | 4,485,402 | BlackRock, Inc. | 30 Sep 2025 | |||
| FRANKLIN RESOURCES INC | 6.1% | -18% | $19,115,560 | +$579,898 | 4,137,567 | +3.1% | Franklin Resources, Inc. | 31 Dec 2024 |
| RA CAPITAL MANAGEMENT, L.P. | 4.7% | $14,699,999 | 3,181,818 | RA Capital Management, L.P. | 31 Dec 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 10% | 8,325,000 | 0% | 8.2% | $118,548,000 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7.5% | 6,192,715 | -9% | 2.7% | $88,184,262 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6.7% | 5,559,782 | -18% | 0.13% | $79,171,296 |
| BlackRock, Inc. | 6% | 4,964,526 | -7.4% | 0% | $70,694,849 |
| FEDERATED HERMES, INC. | 5.3% | 4,416,332 | -4% | 0.11% | $62,888,567 |
| FRANKLIN RESOURCES INC | 5% | 4,171,884 | -3% | 0.01% | $59,407,621 |
| VANGUARD GROUP INC | 4.6% | 3,794,516 | -0.21% | 0% | $54,033,908 |
| TCG Crossover Management, LLC | 4.3% | 3,572,335 | 0% | 2.5% | $50,870,050 |
| CITADEL ADVISORS LLC | 2.6% | 2,135,389 | -8.9% | 0.02% | $30,407,939 |
| Paradigm Biocapital Advisors LP | 2.4% | 2,005,365 | 0.84% | $28,556,398 | |
| ORBIMED ADVISORS LLC | 2.2% | 1,796,000 | 0.61% | $25,575,040 | |
| GEODE CAPITAL MANAGEMENT, LLC | 1.8% | 1,524,526 | -4.2% | 0% | $21,714,141 |
| GOLDMAN SACHS GROUP INC | 1.8% | 1,514,606 | +18% | 0% | $21,567,990 |
| STATE STREET CORP | 1.8% | 1,473,199 | -2.8% | 0% | $20,978,354 |
| Essex Woodlands Management, Inc. | 1.3% | 1,084,857 | -7.3% | 5% | $15,448,362 |
| 5AM Venture Management, LLC | 1.3% | 1,050,000 | 0% | 5.5% | $14,952,000 |
| Patient Square Capital LP | 1.2% | 1,011,839 | -25% | 3.9% | $14,408,587 |
| BANK OF AMERICA CORP /DE/ | 1.2% | 1,010,331 | +24% | 0% | $14,387,118 |
| MORGAN STANLEY | 1.2% | 978,129 | +25% | 0% | $13,928,557 |
| Aberdeen Group plc | 0.96% | 796,802 | -23% | 0.02% | $11,346,460 |
| Balyasny Asset Management L.P. | 0.91% | 756,087 | 0.02% | $10,766,679 | |
| HSBC HOLDINGS PLC | 0.87% | 716,453 | +14% | 0.01% | $10,209,953 |
| Rosalind Advisors, Inc. | 0.78% | 650,000 | 3.4% | $9,256,000 | |
| Artia Global Partners LP | 0.76% | 628,367 | +98% | 1.6% | $8,947,946 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.64% | 531,723 | +180% | 0% | $7,571,736 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 37,079 | $677,809 | -$81,461 | $18.27 | 5 |
| 2025 Q3 | 69,367,962 | $987,669,513 | +$20,151,545 | $14.24 | 147 |
| 2025 Q2 | 68,912,118 | $648,484,078 | -$21,934,697 | $9.41 | 139 |
| 2025 Q1 | 74,070,140 | $401,203,735 | -$6,558,649 | $5.42 | 149 |
| 2024 Q4 | 74,297,439 | $553,342,031 | +$114,449,216 | $7.45 | 141 |
| 2024 Q3 | 58,498,731 | $476,138,729 | -$4,309,954 | $7.99 | 136 |
| 2024 Q2 | 58,402,646 | $508,095,413 | +$27,449,930 | $8.70 | 150 |
| 2024 Q1 | 5,119,174 | $105,809,530 | -$41,155,396 | $20.67 | 30 |
| 2023 Q4 | 34,731 | $802,633 | -$577,265 | $23.11 | 2 |
| 2023 Q3 | 33,692,370 | $269,202,861 | +$16,723,553 | $7.99 | 97 |
| 2023 Q2 | 31,573,084 | $274,684,950 | +$22,852,983 | $8.70 | 82 |
| 2023 Q1 | 29,111,470 | $85,591,090 | -$1,205,999 | $2.94 | 66 |
| 2022 Q4 | 29,367,668 | $102,783,000 | -$6,522,140 | $3.50 | 71 |
| 2022 Q3 | 29,222,642 | $231,148,498 | +$33,401 | $7.91 | 79 |
| 2022 Q2 | 29,188,976 | $229,719,742 | +$661,136 | $7.87 | 75 |
| 2022 Q1 | 30,141,798 | $366,292,357 | +$7,719,907 | $12.15 | 74 |
| 2021 Q4 | 29,823,450 | $365,169,130 | +$95,140,574 | $12.24 | 85 |
| 2021 Q3 | 22,119,997 | $230,462,815 | +$15,007,325 | $10.42 | 62 |
| 2021 Q2 | 20,739,059 | $186,447,743 | +$7,943,490 | $8.99 | 60 |
| 2021 Q1 | 19,642,172 | $199,572,620 | +$124,369,861 | $10.16 | 58 |
| 2020 Q4 | 7,703,318 | $50,684,935 | +$50,684,818 | $6.58 | 33 |