| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BIOTECHNOLOGY VALUE FUND L P | 10% | 0% | $12,276,785 | -$534,102 | 4,632,749 | -4.2% | BVF PARTNERS L P/IL | 31 Mar 2025 |
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | $12,096,898 | 4,564,867 | RA Capital Management, L.P. | 31 Dec 2024 | |||
| GOLDMAN SACHS GROUP INC | 9.6% | $11,722,104 | 4,423,435 | THE GOLDMAN SACHS GROUP, INC. | 31 Dec 2024 | |||
| Novo Holdings A/S | 6.8% | $27,590,750 | 3,175,000 | Novo Holdings A/S | 13 Oct 2025 | |||
| BlackRock, Inc. | 6.6% | -15% | $26,613,959 | -$4,803,137 | 3,062,596 | -15% | BlackRock, Inc. | 30 Sep 2025 |
| JANUS HENDERSON GROUP PLC | 4.9% | $5,968,436 | 2,252,240 | JANUS HENDERSON GROUP PLC | 31 Dec 2024 | |||
| Venrock Healthcare Capital Partners III, L.P. | 1.5% | -82% | $1,795,640 | -$6,028,143 | 677,600 | -77% | Venrock Healthcare Capital Partners III, L.P. | 31 Mar 2025 |
| Deep Track Capital, LP | 1.3% | $1,616,235 | 609,900 | Deep Track Capital, LP | 31 Dec 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| BVF INC/IL | 9.9% | 4,629,289 | 0% | 1.6% | $40,228,521 |
| RA CAPITAL MANAGEMENT, L.P. | 9.8% | 4,563,211 | 0% | 0.49% | $39,654,304 |
| GOLDMAN SACHS GROUP INC | 8.8% | 4,128,416 | -0.74% | 0.01% | $35,875,935 |
| BlackRock, Inc. | 8.3% | 3,869,130 | -3.5% | 0% | $33,622,738 |
| VANGUARD GROUP INC | 5.5% | 2,575,122 | -5.9% | 0% | $22,377,810 |
| NOVO HOLDINGS A/S | 4.3% | 2,000,000 | 0% | 1.1% | $17,380,000 |
| JANUS HENDERSON GROUP PLC | 3.8% | 1,753,367 | -0.06% | 0.01% | $15,236,691 |
| FEDERATED HERMES, INC. | 3.4% | 1,594,832 | -4.3% | 0.02% | $13,859,090 |
| MILLENNIUM MANAGEMENT LLC | 2.5% | 1,149,401 | -23% | 0.01% | $9,988,295 |
| ARMISTICE CAPITAL, LLC | 2.3% | 1,096,000 | +265% | 0.3% | $9,524,240 |
| GEODE CAPITAL MANAGEMENT, LLC | 2% | 913,519 | -0.55% | 0% | $7,940,280 |
| STATE STREET CORP | 1.9% | 903,774 | -6% | 0% | $7,853,796 |
| MORGAN STANLEY | 1.8% | 835,911 | -9.6% | 0% | $7,264,066 |
| BANK OF AMERICA CORP /DE/ | 1.8% | 819,266 | -8.7% | 0% | $7,119,421 |
| Assenagon Asset Management S.A. | 1.4% | 663,657 | +2.3% | 0.01% | $5,767,179 |
| TWO SIGMA ADVISERS, LP | 1.2% | 549,700 | -26% | 0.01% | $4,776,893 |
| DEUTSCHE BANK AG\ | 1.2% | 543,331 | +139% | 0% | $4,721,546 |
| JPMORGAN CHASE & CO | 1.1% | 513,515 | -42% | 0% | $4,462,445 |
| ArrowMark Colorado Holdings LLC | 1.1% | 504,115 | -2% | 0.08% | $4,380,759 |
| RAYMOND JAMES FINANCIAL INC | 1% | 471,270 | +3.5% | 0% | $4,095,336 |
| NORTHERN TRUST CORP | 0.72% | 335,586 | +2% | 0% | $2,916,243 |
| Peapod Lane Capital LLC | 0.69% | 322,081 | +1.1% | 2.5% | $2,798,683 |
| RENAISSANCE TECHNOLOGIES LLC | 0.67% | 313,186 | +169% | 0% | $2,721,586 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.66% | 305,857 | +3.7% | 0% | $2,657,897 |
| TWO SIGMA INVESTMENTS, LP | 0.59% | 273,496 | -49% | 0% | $2,376,680 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 314,050 | $2,354,894 | -$2,636,178 | $7.50 | 5 |
| 2025 Q3 | 39,480,310 | $343,063,021 | -$4,202,041 | $8.69 | 128 |
| 2025 Q2 | 40,399,426 | $151,027,289 | -$9,235,486 | $3.71 | 118 |
| 2025 Q1 | 43,058,381 | $139,823,530 | -$22,403,353 | $3.23 | 122 |
| 2024 Q4 | 46,814,756 | $260,641,875 | -$76,311,870 | $5.57 | 139 |
| 2024 Q3 | 57,424,056 | $620,702,412 | -$40,136,853 | $10.81 | 134 |
| 2024 Q2 | 57,308,865 | $1,203,054,094 | +$3,358,870 | $20.99 | 140 |
| 2024 Q1 | 56,168,310 | $1,788,899,461 | +$448,964,347 | $31.86 | 147 |
| 2023 Q4 | 15,880 | $321,729 | $20.26 | 1 | |
| 2023 Q3 | 41,907,339 | $533,477,373 | +$919,000 | $12.73 | 109 |
| 2023 Q2 | 41,245,744 | $745,276,471 | +$197,025,577 | $18.07 | 99 |
| 2023 Q1 | 30,402,249 | $522,307,520 | +$34,998,616 | $17.19 | 92 |
| 2022 Q4 | 27,996,450 | $621,773,974 | +$47,620,034 | $22.21 | 95 |
| 2022 Q3 | 22,811,889 | $183,402,797 | -$11,574,269 | $8.04 | 80 |
| 2022 Q2 | 24,674,539 | $172,109,260 | +$978,008 | $6.98 | 83 |
| 2022 Q1 | 25,274,573 | $382,194,957 | +$19,406,035 | $15.12 | 70 |
| 2021 Q4 | 23,391,123 | $513,008,297 | +$75,322,119 | $21.94 | 72 |
| 2021 Q3 | 18,780,707 | $504,776,012 | +$68,608,646 | $26.97 | 61 |
| 2021 Q2 | 16,170,891 | $389,389,000 | -$3,186,320 | $24.08 | 52 |
| 2021 Q1 | 15,384,544 | $664,817,567 | +$47,822,437 | $43.38 | 64 |
| 2020 Q4 | 12,998,649 | $536,346,000 | +$512,395,926 | $41.45 | 50 |