| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 15% | +113% | $152,894,064 | +$80,670,694 | 13,056,709 | +112% | FMR LLC | 30 Sep 2025 |
| T. Rowe Price Investment Management, Inc. | 12% | $124,649,133 | 10,644,674 | T. Rowe Price Investment Management, Inc. | 31 Oct 2025 | |||
| Redmile Group, LLC | 6.2% | $45,677,313 | 5,361,187 | Redmile Group, LLC | 31 Mar 2025 | |||
| Point72 Asset Management, L.P. | 5.9% | $34,698,481 | 4,887,110 | Point72 Asset Management, L.P. | 31 Jan 2025 | |||
| Immunome Aggregator, LP | 6% | $33,856,939 | 4,768,583 | Immunome Aggregator, LP | 31 Jan 2025 | |||
| Enavate Sciences GP, LLC | 4.3% | $73,483,864 | 4,768,583 | Enavate Sciences GP, LLC | 18 Dec 2025 | |||
| VANGUARD GROUP INC | 5.2% | +7.8% | $38,552,591 | +$12,963,299 | 4,524,952 | +51% | The Vanguard Group | 30 Jun 2025 |
| EcoR1 Capital, LLC | 4.7% | $28,963,846 | 4,079,415 | EcoR1 Capital, LLC | 31 Mar 2025 | |||
| JANUS HENDERSON GROUP PLC | 2.2% | -55% | $13,594,782 | -$10,942,385 | 1,914,758 | -45% | JANUS HENDERSON GROUP PLC | 31 Mar 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 12% | 13,056,709 | +112% | 0.01% | $152,894,062 |
| T. Rowe Price Investment Management, Inc. | 7.6% | 8,418,163 | +1.7% | 0.06% | $98,577,000 |
| BlackRock, Inc. | 5.3% | 5,822,736 | +0.9% | 0% | $68,184,238 |
| Redmile Group, LLC | 4.5% | 5,023,385 | +3.1% | 5.7% | $58,823,838 |
| VANGUARD GROUP INC | 4.4% | 4,893,626 | +8.1% | 0% | $57,304,359 |
| Point72 Asset Management, L.P. | 4.4% | 4,824,504 | +3% | 0.12% | $56,494,942 |
| ENAVATE SCIENCES GP, LLC | 4.3% | 4,768,583 | 0% | 17% | $55,840,107 |
| EcoR1 Capital, LLC | 3.7% | 4,079,415 | 0% | 2.3% | $47,769,950 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.4% | 3,742,770 | +26% | 0% | $43,829,000 |
| Opaleye Management Inc. | 2.9% | 3,185,000 | -9.8% | 5.3% | $37,296,350 |
| PRIMECAP MANAGEMENT CO/CA/ | 2.7% | 3,018,009 | -0.07% | 0.03% | $35,340,897 |
| STATE STREET CORP | 2.5% | 2,803,973 | +11% | 0% | $32,834,524 |
| Jefferies Financial Group Inc. | 1.9% | 2,100,000 | +0.69% | 0.23% | $24,591,000 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.7% | 1,894,575 | +1.8% | 0% | $22,188,380 |
| MORGAN STANLEY | 1.7% | 1,833,818 | +354% | 0% | $21,474,020 |
| READYSTATE ASSET MANAGEMENT LP | 1.2% | 1,318,290 | -2.6% | 0.75% | $15,437,176 |
| Woodline Partners LP | 1.1% | 1,274,729 | -23% | 0.07% | $14,927,077 |
| PRINCIPAL FINANCIAL GROUP INC | 1% | 1,104,938 | +222% | 0.01% | $12,938,824 |
| Polar Capital Holdings Plc | 0.95% | 1,058,776 | +5.9% | 0.06% | $12,398,267 |
| Caption Management, LLC | 0.94% | 1,040,700 | 0.71% | $12,186,597 | |
| TORONTO DOMINION BANK | 0.93% | 1,036,056 | -50% | 0.02% | $12,132,216 |
| Candriam S.C.A. | 0.78% | 859,527 | +170% | 0.05% | $10,065,061 |
| CITADEL ADVISORS LLC | 0.76% | 841,138 | 0.01% | $9,849,726 | |
| JANUS HENDERSON GROUP PLC | 0.69% | 763,175 | -27% | 0% | $8,936,780 |
| NORTHERN TRUST CORP | 0.64% | 706,515 | +2.2% | 0% | $8,273,291 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 1,379 | $29,621 | +$9,473 | $21.48 | 1 |
| 2025 Q3 | 91,384,562 | $1,070,118,014 | +$140,282,298 | $11.71 | 153 |
| 2025 Q2 | 79,431,966 | $738,692,421 | +$30,839,788 | $9.30 | 142 |
| 2025 Q1 | 76,944,016 | $518,447,178 | +$156,655,117 | $6.73 | 141 |
| 2024 Q4 | 53,313,062 | $566,314,819 | -$37,081,320 | $10.62 | 118 |
| 2024 Q3 | 51,626,873 | $754,667,426 | +$58,648,728 | $14.62 | 114 |
| 2024 Q2 | 47,785,575 | $578,187,395 | +$107,072,667 | $12.10 | 111 |
| 2024 Q1 | 36,614,486 | $903,559,209 | +$374,513,778 | $24.68 | 102 |
| 2023 Q4 | 18,473 | $197,661 | +$172,270 | $10.70 | 2 |
| 2023 Q3 | 2,726,703 | $22,686,988 | +$3,520,502 | $8.35 | 34 |
| 2023 Q2 | 1,918,012 | $15,176,031 | +$582,030 | $7.91 | 33 |
| 2023 Q1 | 1,857,722 | $9,331,898 | -$1,198,232 | $4.99 | 29 |
| 2022 Q4 | 2,005,682 | $4,424,100 | -$694,149 | $2.21 | 26 |
| 2022 Q3 | 2,299,665 | $10,206,297 | -$15,589 | $4.43 | 22 |
| 2022 Q2 | 2,285,459 | $7,336,000 | -$1,185,146 | $3.21 | 23 |
| 2022 Q1 | 2,694,238 | $15,433,000 | -$849,549 | $5.68 | 28 |
| 2021 Q4 | 2,712,257 | $35,345,000 | +$3,974,276 | $12.96 | 28 |
| 2021 Q3 | 2,391,524 | $58,323,000 | -$1,021,412 | $24.35 | 33 |
| 2021 Q2 | 2,376,209 | $41,108,000 | +$6,433,363 | $17.30 | 26 |
| 2021 Q1 | 1,909,240 | $64,673,000 | +$1,324,026 | $33.86 | 30 |
| 2020 Q4 | 2,013,500 | $19,489,000 | +$19,488,966 | $9.68 | 24 |