| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 14% | $182,077,941 | 7,051,818 | T. Rowe Price Investment Management, Inc. | 31 Mar 2025 | |||
| WELLINGTON MANAGEMENT GROUP LLP | 10% | +12% | $152,909,031 | +$18,391,571 | 5,132,898 | +14% | Wellington Management Group LLP | 31 Jul 2025 |
| Jallal Bahija | 8.2% | $116,012,849 | 4,493,139 | Jallal Bahija | 31 Dec 2024 | |||
| PRIMECAP MANAGEMENT CO/CA/ | 7.5% | +44% | $121,616,824 | +$35,582,772 | 3,772,234 | +41% | PRIMECAP MANAGEMENT CO/CA/ | 30 Jun 2025 |
| Bellevue Group AG | 5.6% | $101,607,853 | 2,796,803 | Bellevue Group AG | 20 Aug 2025 | |||
| TANG CAPITAL MANAGEMENT LLC | 5.2% | $94,662,520 | 2,605,608 | TANG CAPITAL MANAGEMENT, LLC | 17 Oct 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 14% | 7,063,896 | -0.05% | 0.16% | $256,632,000 |
| RTW INVESTMENTS, LP | 9.8% | 4,869,798 | 0% | 2.2% | $176,919,761 |
| WELLINGTON MANAGEMENT GROUP LLP | 9.6% | 4,780,889 | +13% | 0.03% | $173,689,698 |
| FMR LLC | 8.9% | 4,420,403 | -9% | 0.01% | $160,593,235 |
| PRIMECAP MANAGEMENT CO/CA/ | 7.5% | 3,754,560 | -0.45% | 0.1% | $136,403,165 |
| Bellevue Group AG | 5.6% | 2,796,803 | +15% | 2.1% | $101,607,853 |
| BAKER BROS. ADVISORS LP | 4.7% | 2,322,656 | 0% | 0.61% | $84,382,092 |
| TANG CAPITAL MANAGEMENT LLC | 4.6% | 2,305,608 | +9.5% | 3.2% | $83,762,739 |
| Deep Track Capital, LP | 3.6% | 1,800,000 | 0% | 1.8% | $65,394,000 |
| BVF INC/IL | 3.2% | 1,574,288 | +54% | 2.3% | $57,193,883 |
| MILLENNIUM MANAGEMENT LLC | 2.5% | 1,265,965 | +358% | 0.04% | $45,992,508 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2% | 1,016,771 | +1.1% | 0% | $36,940,000 |
| Kynam Capital Management, LP | 2% | 1,009,267 | +3.4% | 2.7% | $36,666,670 |
| Logos Global Management LP | 1.7% | 850,000 | +48% | 3.1% | $30,880,500 |
| ARMISTICE CAPITAL, LLC | 1.6% | 824,000 | +22% | 0.94% | $29,935,920 |
| Fiera Capital Corp | 1.6% | 795,157 | -2.2% | 0.09% | $28,888,053 |
| Point72 Asset Management, L.P. | 1.1% | 535,831 | -35% | 0.04% | $19,466,740 |
| Caption Management, LLC | 0.93% | 463,662 | +158% | 0.98% | $16,844,840 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0.89% | 442,398 | -0.76% | 0% | $16,072,319 |
| PRINCIPAL FINANCIAL GROUP INC | 0.82% | 411,409 | -9.6% | 0.01% | $14,946,489 |
| Frazier Life Sciences Management, L.P. | 0.77% | 384,782 | 0% | 0.42% | $13,979,130 |
| Hudson Bay Capital Management LP | 0.67% | 333,558 | -3.6% | 0.07% | $12,118,162 |
| TWO SIGMA ADVISERS, LP | 0.66% | 330,000 | -36% | 0.02% | $11,988,900 |
| TD Asset Management Inc | 0.58% | 288,860 | +0.91% | 0.01% | $10,494,284 |
| Candriam S.C.A. | 0.54% | 269,729 | +100% | 0.05% | $9,799,255 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 9,561 | $332,308 | +$35,772 | 3,471% | 3 |
| 2025 Q3 | 49,180,519 | $1,786,666,273 | +$50,908,661 | 3,633% | 131 |
| 2025 Q2 | 47,759,431 | $1,498,675,257 | +$17,984,717 | 3,138% | 132 |
| 2025 Q1 | 47,287,653 | $1,402,998,146 | +$60,274,162 | 2,967% | 115 |
| 2024 Q4 | 45,397,254 | $1,339,170,351 | -$4,700,092 | 2,950% | 113 |
| 2024 Q3 | 45,275,292 | $1,410,431,002 | +$61,178,963 | 3,113% | 129 |
| 2024 Q2 | 43,012,978 | $1,457,966,231 | -$100,415,189 | 3,389% | 135 |
| 2024 Q1 | 41,210,539 | $2,678,311,141 | +$247,060,152 | 6,500% | 153 |
| 2023 Q4 | 168,168 | $11,489,238 | +$5,431,098 | 6,832% | 3 |
| 2023 Q3 | 36,920,468 | $1,916,148,784 | +$85,343,515 | 5,190% | 123 |
| 2023 Q2 | 35,286,231 | $2,114,539,636 | +$164,445,131 | 5,996% | 116 |
| 2023 Q1 | 32,686,114 | $1,614,452,190 | +$118,535,242 | 4,944% | 107 |
| 2022 Q4 | 30,228,946 | $1,725,187,126 | +$251,722,518 | 5,707% | 100 |
| 2022 Q3 | 26,348,834 | $1,236,656,033 | +$213,109,146 | 4,694% | 80 |
| 2022 Q2 | 21,016,054 | $783,633,369 | +$55,802,507 | 3,730.92% | 64 |
| 2022 Q1 | 19,739,703 | $590,121,252 | +$57,741,645 | 2,989.99% | 57 |
| 2021 Q4 | 17,133,052 | $586,618,000 | +$22,048,630 | 3,423.96% | 45 |
| 2021 Q3 | 16,654,128 | $617,381,000 | +$83,084,367 | 3,706.96% | 46 |
| 2021 Q2 | 13,805,484 | $538,110,000 | +$9,423,884 | 3,905% | 42 |
| 2021 Q1 | 14,110,965 | $597,836,000 | +$597,834,944 | 4,257.05% | 41 |