| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 10% | +233% | $8,531,675 | +$6,622,427 | 12,016,444 | +347% | JANUS HENDERSON GROUP PLC | 28 Nov 2025 |
| Alyeska Investment Group, L.P. | 9.4% | -5.5% | $9,918,000 | +$1,555,199 | 11,250,000 | +19% | Alyeska Investment Group, L.P. | 30 Sep 2025 |
| Nantahala Capital Management, LLC | 10% | $9,039,380 | 10,634,565 | Nantahala Capital Management, LLC | 30 Jun 2025 | |||
| 683 Capital Management, LLC | 9.9% | $10,528,102 | 10,634,446 | 683 CAPITAL MANAGEMENT, LLC | 02 Aug 2025 | |||
| Adage Capital Management, L.P. | 10% | +422% | $7,309,338 | +$6,333,814 | 10,479,337 | +649% | Adage Capital Management, L.P. | 30 Jun 2025 |
| BIOTECHNOLOGY VALUE FUND L P | 10% | $8,317,401 | 9,785,178 | BVF PARTNERS L P/IL | 30 Jun 2025 | |||
| Aberdeen Group plc | 8.6% | $8,161,502 | 8,243,941 | Aberdeen Group plc | 30 Jun 2025 | |||
| Avidity Partners Management LP | 4.8% | -18% | $4,143,001 | -$807,898 | 4,699,411 | -16% | Avidity Partners Management LP | 30 Sep 2025 |
| VANGUARD GROUP INC | 4.4% | $3,531,387 | 3,923,763 | The Vanguard Group | 31 Dec 2024 | |||
| Soleus Private Equity Fund III, L.P. | 1.6% | $1,392,934 | 1,580,007 | Soleus Capital Management, L.P. | 30 Sep 2025 | |||
| RTW INVESTMENTS, LP | 1.1% | $924,086 | 1,026,762 | RTW Investments, LP | 31 Mar 2025 | |||
| ARMISTICE CAPITAL, LLC | 5% | -50% | $328,030 | -$49,773 | 372,085 | -13% | Armistice Capital, LLC | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Aberdeen Group plc | 6.9% | 8,243,941 | 0% | 0.01% | $7,267,858 |
| BVF INC/IL | 6.4% | 7,652,972 | 0% | 0.27% | $6,746,860 |
| Avidity Partners Management LP | 3.9% | 4,699,411 | -16% | 0.94% | $4,143,001 |
| VANGUARD GROUP INC | 3.6% | 4,345,105 | +5.3% | 0% | $3,832,383 |
| MORGAN STANLEY | 2.6% | 3,103,122 | -14% | 0% | $2,735,712 |
| Focus Partners Wealth | 2.1% | 2,581,587 | +1.5% | 0% | $2,275,927 |
| Laurion Capital Management LP | 1.6% | 1,882,162 | -1.2% | 0.23% | $1,659,314 |
| Soleus Capital Management, L.P. | 1.3% | 1,580,007 | -78% | 0.07% | $1,392,934 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.2% | 1,398,600 | 0% | 0% | $1,233,006 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.86% | 1,033,772 | +6.1% | 0% | $911,653 |
| Ikarian Capital, LLC | 0.76% | 914,170 | 0% | 0.18% | $805,932 |
| BlackRock, Inc. | 0.6% | 725,743 | +3.9% | 0% | $639,815 |
| CITADEL ADVISORS LLC | 0.44% | 535,083 | 0% | $471,729 | |
| MARSHALL WACE, LLP | 0.44% | 533,515 | +967% | 0% | $469,492 |
| MILLENNIUM MANAGEMENT LLC | 0.44% | 530,470 | +414% | 0% | $467,662 |
| RENAISSANCE TECHNOLOGIES LLC | 0.33% | 391,653 | +196% | 0% | $345,281 |
| STATE STREET CORP | 0.28% | 331,945 | 0% | 0% | $292,643 |
| Squarepoint Ops LLC | 0.23% | 271,574 | 0% | $239,420 | |
| BOOTHBAY FUND MANAGEMENT, LLC | 0.2% | 240,873 | 0% | 0.01% | $212,354 |
| NORTHERN TRUST CORP | 0.18% | 211,347 | -18% | 0% | $186,323 |
| JANE STREET GROUP, LLC | 0.16% | 195,331 | 0% | $172,204 | |
| GSA CAPITAL PARTNERS LLP | 0.16% | 192,923 | 0.01% | $170,000 | |
| Exome Asset Management LLC | 0.14% | 173,900 | 0.1% | $153,310 | |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0.1% | 115,000 | 0% | 0% | $101,384 |
| Virtu Financial LLC | 0.09% | 112,287 | 0.01% | $99,000 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 10,000 | $5,337 | 53.37% | 1 | |
| 2025 Q3 | 42,691,219 | $37,637,800 | -$6,009,905 | 88.16% | 61 |
| 2025 Q2 | 50,178,419 | $35,007,422 | +$6,044,811 | 69.75% | 55 |
| 2025 Q1 | 40,453,267 | $44,092,350 | -$10,908,224 | 109% | 63 |
| 2024 Q4 | 51,078,929 | $51,080,793 | -$5,071,048 | 100% | 65 |
| 2024 Q3 | 55,990,706 | $92,402,857 | +$4,082,992 | 165% | 61 |
| 2024 Q2 | 55,825,550 | $62,078,863 | -$1,856,880 | 111% | 57 |
| 2024 Q1 | 57,356,707 | $75,746,429 | +$55,507,141 | 132% | 60 |
| 2023 Q4 | 15,053,342 | $22,577,900 | -$4,814,035 | 150% | 48 |
| 2023 Q3 | 18,267,619 | $26,851,561 | -$3,476,639 | 147% | 52 |
| 2023 Q2 | 20,191,368 | $50,673,312 | -$8,732,685 | 251% | 62 |
| 2023 Q1 | 24,698,571 | $36,797,274 | +$3,207,790 | 149% | 56 |
| 2022 Q4 | 23,902,583 | $33,408,429 | +$4,477,561 | 140% | 56 |
| 2022 Q3 | 16,966,507 | $53,607,794 | -$3,014,898 | 316% | 58 |
| 2022 Q2 | 17,750,419 | $61,580,669 | -$12,047,018 | 347% | 61 |
| 2022 Q1 | 17,604,014 | $198,924,802 | +$44,418,632 | 1,130% | 77 |
| 2021 Q4 | 13,709,674 | $131,117,717 | +$7,601,585 | 957.02% | 66 |
| 2021 Q3 | 12,872,644 | $113,978,993 | +$30,166,210 | 884.95% | 66 |
| 2021 Q2 | 9,414,644 | $115,422,222 | -$1,376,618 | 1,226% | 55 |
| 2021 Q1 | 9,296,231 | $148,180,917 | -$6,245,917 | 1,594% | 58 |
| 2020 Q4 | 9,017,659 | $137,884,642 | +$12,983,212 | 1,529.06% | 64 |
| 2020 Q3 | 8,545,770 | $158,687,665 | +$86,119,339 | 1,856.97% | 63 |
| 2020 Q2 | 4,205,096 | $51,006,563 | +$24,949,309 | 1,212% | 46 |
| 2020 Q1 | 2,123,281 | $12,844,030 | +$114,567 | 601.07% | 14 |
| 2019 Q4 | 2,138,394 | $20,743,048 | +$6,193,886 | 969.99% | 13 |
| 2019 Q3 | 1,499,234 | $14,992,920 | -$480,103 | 1,000% | 17 |
| 2019 Q2 | 1,536,778 | $17,625,202 | +$17,623,037 | 1,145.54% | 20 |