| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JPMORGAN CHASE & CO | 11% | +36% | $2,979,237,899 | +$1,016,142,500 | 23,014,584 | +52% | JPMORGAN CHASE & CO. | 29 Aug 2025 |
| Darwin Global Management, Ltd. | 9.7% | +13% | $2,946,076,654 | +$728,614,275 | 20,457,445 | +33% | Darwin Global Management, Ltd. | 30 Sep 2025 |
| VANGUARD GROUP INC | 10% | $1,249,274,979 | 18,218,973 | The Vanguard Group | 31 Dec 2024 | |||
| BlackRock, Inc. | 5.1% | $638,556,339 | 9,729,641 | BlackRock, Inc. | 30 Jun 2025 | |||
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.3% | -43% | $998,278,616 | -$619,088,189 | 6,932,009 | -38% | T. Rowe Price Associates, Inc. | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| JPMORGAN CHASE & CO | 11% | 23,047,676 | +47% | 0.21% | $3,319,096,045 |
| Darwin Global Management, Ltd. | 9.7% | 20,457,445 | +5.8% | 81% | $2,897,797,084 |
| VANGUARD GROUP INC | 9.5% | 19,935,820 | +13% | 0.04% | $2,870,957,439 |
| BlackRock, Inc. | 5.9% | 12,364,904 | +11% | 0.03% | $1,780,669,886 |
| FMR LLC | 4.4% | 9,180,963 | +80% | 0.07% | $1,322,150,532 |
| Capital International Investors | 3.6% | 7,553,853 | +1% | 0.18% | $1,087,830,371 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.3% | 6,931,466 | -38% | 0.11% | $998,201,000 |
| BAKER BROS. ADVISORS LP | 3.2% | 6,703,484 | -13% | 7% | $965,368,731 |
| D. E. Shaw & Co., Inc. | 2.7% | 5,657,464 | +65% | 0.66% | $814,731,390 |
| Artisan Partners Limited Partnership | 2.3% | 4,937,683 | +49% | 1% | $711,075,729 |
| STATE STREET CORP | 1.9% | 3,984,354 | -6.9% | 0.02% | $573,786,820 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.8% | 3,759,427 | +13% | 0.03% | $541,500,912 |
| Orbis Allan Gray Ltd | 1.5% | 3,250,868 | +113% | 2% | $468,157,501 |
| RTW INVESTMENTS, LP | 1.5% | 3,084,558 | 0% | 5.5% | $444,207,198 |
| AMERIPRISE FINANCIAL INC | 1.3% | 2,721,879 | -8% | 0.09% | $391,978,689 |
| Duquesne Family Office LLC | 1.1% | 2,423,435 | +7.5% | 8.9% | $348,999,000 |
| MILLENNIUM MANAGEMENT LLC | 1.1% | 2,336,112 | +10% | 0.26% | $336,423,489 |
| FRANKLIN RESOURCES INC | 1% | 2,139,725 | -9% | 0.08% | $308,141,793 |
| CITADEL ADVISORS LLC | 0.98% | 2,057,641 | +34% | 0.24% | $296,320,880 |
| Invesco Ltd. | 0.95% | 2,003,871 | +5.7% | 0.05% | $288,577,400 |
| UBS Group AG | 0.78% | 1,646,239 | +461% | 0.05% | $237,074,878 |
| BANK OF AMERICA CORP /DE/ | 0.76% | 1,601,806 | +31% | 0.02% | $230,676,015 |
| Integral Health Asset Management, LLC | 0.76% | 1,600,000 | 0% | 17% | $230,416,000 |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 0.74% | 1,555,057 | -6.6% | 0.58% | $223,943,759 |
| Qube Research & Technologies Ltd | 0.73% | 1,544,315 | +43% | 0.31% | $222,396,803 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 230,527 | $40,143,602 | +$8,528,848 | 17,404.01% | 23 |
| 2025 Q3 | 210,841,539 | $30,319,625,983 | +$444,550,906 | 14,401% | 559 |
| 2025 Q2 | 210,375,071 | $21,148,644,502 | +$1,358,876,883 | 10,064% | 513 |
| 2025 Q1 | 197,786,281 | $15,116,972,595 | +$439,019,600 | 7,629% | 434 |
| 2024 Q4 | 192,527,267 | $13,292,738,007 | +$359,910,615 | 6,904% | 433 |
| 2024 Q3 | 186,369,640 | $13,609,899,197 | +$788,441,234 | 7,300% | 417 |
| 2024 Q2 | 175,224,446 | $11,739,684,387 | +$1,877,920,034 | 6,700% | 386 |
| 2024 Q1 | 148,158,709 | $4,019,244,934 | -$31,967,825 | 2,713% | 292 |
| 2023 Q4 | 760,508 | $23,603,843 | -$1,865,147 | 3,099% | 4 |
| 2023 Q3 | 146,032,292 | $3,687,371,189 | +$65,828,154 | 2,525% | 245 |
| 2023 Q2 | 145,059,040 | $3,059,024,756 | +$10,494,836 | 2,110% | 217 |
| 2023 Q1 | 145,015,629 | $2,471,116,820 | +$36,808,267 | 1,705% | 225 |
| 2022 Q4 | 143,260,347 | $2,861,469,379 | +$304,703,355 | 1,998% | 220 |
| 2022 Q3 | 122,237,646 | $2,632,332,495 | -$228,935,632 | 2,154% | 222 |
| 2022 Q2 | 124,778,070 | $2,460,586,454 | +$52,999,190 | 1,972% | 192 |
| 2022 Q1 | 124,822,306 | $2,933,013,983 | +$71,229,923 | 2,350% | 203 |
| 2021 Q4 | 122,664,146 | $3,340,961,428 | -$21,790,965 | 2,724% | 197 |
| 2021 Q3 | 123,224,771 | $3,393,033,011 | +$40,004,457 | 2,753.99% | 184 |
| 2021 Q2 | 121,291,929 | $3,451,027,116 | +$433,237,481 | 2,845.99% | 192 |
| 2021 Q1 | 106,365,592 | $3,623,365,138 | -$7,459,721 | 3,405.99% | 191 |
| 2020 Q4 | 107,470,161 | $3,577,700,188 | -$45,352,156 | 3,328.99% | 199 |
| 2020 Q3 | 108,633,312 | $3,492,408,174 | -$56,320,811 | 3,214% | 192 |
| 2020 Q2 | 110,614,674 | $3,042,730,072 | +$366,899,141 | 2,754% | 179 |
| 2020 Q1 | 96,918,498 | $1,551,541,262 | -$33,078,495 | 1,602.95% | 154 |
| 2019 Q4 | 98,271,379 | $2,346,683,431 | -$38,862,242 | 2,387.99% | 168 |
| 2019 Q3 | 98,283,130 | $1,733,785,567 | -$528,921,020 | 1,764.01% | 149 |
| 2019 Q2 | 126,210,706 | $3,230,856,286 | +$1,164,922,788 | 2,559.99% | 161 |
| 2019 Q1 | 82,099,140 | $2,386,629,092 | -$5,035,428 | 2,907.04% | 147 |
| 2018 Q4 | 82,348,800 | $1,080,398,004 | -$9,301,326 | 1,312% | 118 |
| 2018 Q3 | 80,865,892 | $1,635,190,434 | -$43,327,917 | 2,022.03% | 119 |
| 2018 Q2 | 82,432,384 | $1,949,511,562 | +$34,162,570 | 2,365% | 123 |
| 2018 Q1 | 81,803,945 | $1,842,181,409 | +$127,628,626 | 2,252% | 124 |
| 2017 Q4 | 75,850,426 | $2,365,010,554 | +$46,221,696 | 3,117.95% | 123 |
| 2017 Q3 | 73,702,053 | $2,292,322,507 | +$540,983,964 | 3,120.95% | 139 |
| 2017 Q2 | 55,518,883 | $952,476,710 | +$47,870,993 | 1,716% | 106 |
| 2017 Q1 | 56,907,397 | $996,429,125 | +$70,323,736 | 1,750.99% | 94 |
| 2016 Q4 | 57,798,899 | $764,690,750 | +$2,353,591 | 1,322.99% | 95 |
| 2016 Q3 | 57,474,912 | $834,201,194 | +$19,210,125 | 1,452% | 93 |
| 2016 Q2 | 56,451,131 | $556,714,141 | -$8,092,016 | 986% | 103 |
| 2016 Q1 | 57,021,750 | $722,299,325 | -$12,896,841 | 1,266.98% | 95 |
| 2015 Q4 | 56,611,322 | $1,027,775,029 | +$271,580 | 1,815% | 109 |
| 2015 Q3 | 56,767,634 | $1,053,878,972 | +$35,394,353 | 1,857.01% | 117 |
| 2015 Q2 | 53,487,923 | $1,305,926,938 | +$18,182,625 | 2,442.01% | 113 |
| 2015 Q1 | 51,586,306 | $1,073,247,187 | +$252,791,465 | 2,079.99% | 114 |
| 2014 Q4 | 41,624,153 | $643,979,215 | +$12,732,458 | 1,546.99% | 91 |
| 2014 Q3 | 41,269,857 | $538,661,902 | +$115,633,278 | 1,305.01% | 99 |
| 2014 Q2 | 29,678,717 | $592,680,286 | -$7,577 | 1,998.02% | 101 |
| 2014 Q1 | 29,211,820 | $555,208,840 | +$49,175,482 | 1,903.98% | 106 |