| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 11% | -10% | $248,822,799 | -$29,612,330 | 3,353,407 | -11% | BlackRock, Inc. | 30 Sep 2025 |
| CITADEL ADVISORS LLC | 5.8% | $127,107,716 | 1,713,042 | Kenneth Griffin | 29 Sep 2025 | |||
| Flynn James E | 5.1% | $109,541,683 | 1,476,303 | Deerfield Mgmt, L.P. | 06 Nov 2025 | |||
| FMR LLC | 2.5% | -72% | $55,005,358 | -$130,571,372 | 741,312 | -70% | FMR LLC | 30 Sep 2025 |
| WASATCH ADVISORS LP | 0.5% | -92% | $10,084,819 | -$103,003,921 | 135,914 | -91% | Wasatch Advisors LP | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| BlackRock, Inc. | 12% | 3,547,195 | -8.4% | 0% | $263,201,869 |
| VANGUARD GROUP INC | 10% | 3,000,087 | -6.4% | 0% | $222,606,456 |
| CITADEL ADVISORS LLC | 6% | 1,748,409 | +20055% | 0.1% | $129,731,948 |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 4.5% | 1,297,573 | +69% | 0.25% | $96,279,917 |
| BAILLIE GIFFORD & CO | 3.7% | 1,084,350 | -2.7% | 0.06% | $80,458,771 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3.6% | 1,047,694 | +648% | 1.2% | $77,738,895 |
| STATE STREET CORP | 3.4% | 979,309 | -5% | 0% | $72,664,728 |
| BRAIDWELL LP | 3% | 883,747 | +69% | 1.9% | $65,574,027 |
| UBS AM, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS LLC | 2.9% | 833,599 | +37% | 0.01% | $61,853,047 |
| FMR LLC | 2.6% | 749,312 | -67% | 0% | $55,598,958 |
| Soleus Capital Management, L.P. | 2.5% | 728,188 | +568% | 2.9% | $54,031,550 |
| JANUS HENDERSON GROUP PLC | 2.3% | 667,078 | +4.1% | 0.02% | $49,496,529 |
| Balyasny Asset Management L.P. | 2.1% | 614,359 | 0.09% | $45,585,438 | |
| Artisan Partners Limited Partnership | 1.8% | 526,242 | +45% | 0.06% | $39,047,156 |
| BNP PARIBAS FINANCIAL MARKETS | 1.8% | 522,180 | 0% | 0.03% | $38,745,756 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.7% | 504,987 | -1.5% | 0% | $37,476,743 |
| UBS Group AG | 1.6% | 467,736 | +8.6% | 0.01% | $34,706,011 |
| MORGAN STANLEY | 1.6% | 450,641 | +49% | 0% | $33,437,643 |
| Champlain Investment Partners, LLC | 1.4% | 407,059 | -1.2% | 0.23% | $30,203,778 |
| Aberdeen Group plc | 1.4% | 396,340 | +63% | 0.05% | $29,967,267 |
| D. E. Shaw & Co., Inc. | 1.2% | 358,857 | +2423% | 0.02% | $26,627,189 |
| MILLENNIUM MANAGEMENT LLC | 1.2% | 356,808 | 0.02% | $26,475,154 | |
| DIMENSIONAL FUND ADVISORS LP | 1.2% | 343,718 | -0.33% | 0.01% | $25,506,313 |
| FRANKLIN RESOURCES INC | 1% | 297,245 | +30% | 0.01% | $22,055,613 |
| BANK OF AMERICA CORP /DE/ | 0.99% | 288,828 | +14% | 0% | $21,431,039 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 19,848 | $1,821,700 | +$603,871 | $92.23 | 7 |
| 2025 Q3 | 31,092,183 | $2,308,506,740 | -$491,054,263 | $74.20 | 318 |
| 2025 Q2 | 33,831,801 | $4,392,084,401 | -$58,153,313 | $129.77 | 355 |
| 2025 Q1 | 34,106,290 | $5,427,649,475 | +$99,882,141 | $159.28 | 357 |
| 2024 Q4 | 33,394,193 | $6,197,701,258 | +$41,500,025 | $185.38 | 351 |
| 2024 Q3 | 33,044,652 | $6,968,128,155 | -$39,544,759 | $211.05 | 348 |
| 2024 Q2 | 31,603,291 | $4,230,231,298 | -$102,711,395 | $133.83 | 325 |
| 2024 Q1 | 31,507,632 | $6,770,323,429 | +$89,154,482 | $214.79 | 325 |
| 2023 Q4 | 213,187 | $43,368,632 | -$28,053,235 | $203.43 | 2 |
| 2023 Q3 | 28,121,074 | $5,580,309,683 | -$50,640,152 | $198.44 | 351 |
| 2023 Q2 | 27,736,761 | $9,003,158,481 | -$221,258,682 | $324.64 | 396 |
| 2023 Q1 | 28,489,826 | $6,668,110,887 | +$65,995,847 | $234.07 | 365 |
| 2022 Q4 | 28,017,286 | $7,056,154,404 | +$112,988,747 | $251.88 | 327 |
| 2022 Q3 | 26,704,367 | $4,739,143,764 | +$151,773,954 | $177.37 | 284 |
| 2022 Q2 | 27,428,310 | $5,012,803,475 | +$90,598,395 | $182.67 | 273 |
| 2022 Q1 | 26,467,088 | $6,790,843,060 | +$353,336,351 | $256.69 | 288 |
| 2021 Q4 | 25,810,517 | $5,938,752,044 | +$69,832,759 | $230.06 | 280 |
| 2021 Q3 | 25,371,602 | $5,908,200,728 | +$103,088,184 | $232.88 | 247 |
| 2021 Q2 | 24,992,235 | $4,831,728,707 | -$54,745,405 | $193.26 | 246 |
| 2021 Q1 | 25,166,598 | $5,209,161,369 | +$95,111,548 | $206.99 | 249 |
| 2020 Q4 | 25,136,412 | $4,728,102,287 | -$141,123,488 | $188.09 | 235 |
| 2020 Q3 | 26,143,940 | $3,374,160,696 | -$40,346,686 | $129.05 | 200 |
| 2020 Q2 | 26,862,057 | $2,351,458,452 | +$327,472,776 | $87.02 | 184 |
| 2020 Q1 | 19,092,065 | $1,150,573,501 | -$149,508,782 | $60.28 | 159 |
| 2019 Q4 | 22,240,449 | $1,650,460,334 | +$34,653,932 | $74.21 | 168 |
| 2019 Q3 | 21,442,150 | $1,308,397,700 | +$112,747,407 | $61.02 | 151 |
| 2019 Q2 | 19,924,701 | $1,208,429,776 | +$175,477,981 | $60.65 | 143 |
| 2019 Q1 | 17,738,168 | $1,007,140,751 | +$168,473,024 | $56.78 | 142 |
| 2018 Q4 | 14,874,625 | $628,449,909 | +$161,578,630 | $42.25 | 102 |
| 2018 Q3 | 9,253,107 | $389,362,304 | -$3,132,255 | $42.08 | 84 |
| 2018 Q2 | 9,448,509 | $336,936,129 | +$336,926,833 | $35.66 | 75 |