| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 19.9% | $321M | 12M | RA Capital Management, L.P. | Mar 6, 2025 | |||
| JANUS HENDERSON GROUP PLC | 10% | +31.3% | $147M | $38.5M | 6.03M | +35.3% | JANUS HENDERSON GROUP PLC | Oct 31, 2025 |
| BlackRock, Inc. | 5.7% | $85.5M | 3.35M | BlackRock, Inc. | Jun 30, 2025 | |||
| Paradigm Biocapital Advisors LP | 4.9% | -18.3% | $67.3M | -$13.7M | 2.92M | -16.9% | Paradigm BioCapital Advisors LP | Jun 30, 2025 |
| Adage Capital Management, L.P. | 4.27% | -20.8% | $58.3M | -$12.4M | 2.53M | -17.5% | Adage Capital Management, L.P. | Jun 30, 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 65M | $1.59B | -$4.06M | $24.44 | 163 |
| 2025 Q2 | 65.4M | $1.51B | -$28.1M | $23.10 | 170 |
| 2025 Q1 | 66.5M | $1.81B | -$17.6M | $27.00 | 179 |
| 2024 Q4 | 64.1M | $3.43B | +$1B | $53.54 | 212 |
| 2024 Q3 | 45.6M | $2.07B | +$42.3M | $45.43 | 159 |
| 2024 Q2 | 44.7M | $1.87B | +$108M | $41.89 | 152 |
| 2024 Q1 | 42.3M | $1.59B | +$332M | $37.65 | 118 |
| 2023 Q4 | 33.5M | $360M | -$17.7M | $10.73 | 64 |
| 2023 Q3 | 35.1M | $354M | +$43.9M | $10.08 | 57 |
| 2023 Q2 | 30.5M | $362M | -$1.13M | $11.87 | 54 |
| 2023 Q1 | 30.5M | $370M | +$18.6M | $12.10 | 48 |
| 2022 Q4 | 29M | $381M | -$7.76M | $13.17 | 48 |
| 2022 Q3 | 29.5M | $400M | +$8.92M | $13.54 | 44 |
| 2022 Q2 | 28.9M | $352M | +$6.49M | $12.21 | 39 |
| 2022 Q1 | 28.3M | $407M | +$10.9M | $14.34 | 45 |
| 2021 Q4 | 27.5M | $541M | +$19.1M | $19.73 | 45 |
| 2021 Q3 | 26.5M | $571M | +$36.9M | $21.63 | 45 |
| 2021 Q2 | 24.7M | $614M | +$614M | $24.95 | 29 |