| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 20% | $321,192,045 | 11,971,377 | RA Capital Management, L.P. | 06 Mar 2025 | |||
| JANUS HENDERSON GROUP PLC | 10% | +31% | $147,469,714 | +$38,459,199 | 6,033,949 | +35% | JANUS HENDERSON GROUP PLC | 31 Oct 2025 |
| FMR LLC | 5.8% | $48,484,949 | 3,512,384 | FMR LLC | 31 Dec 2025 | |||
| BlackRock, Inc. | 5.7% | $85,515,172 | 3,345,664 | BlackRock, Inc. | 30 Jun 2025 | |||
| Paradigm Biocapital Advisors LP | 4.9% | -18% | $67,311,947 | -$13,731,530 | 2,920,258 | -17% | Paradigm BioCapital Advisors LP | 30 Jun 2025 |
| Adage Capital Management, L.P. | 4.3% | -21% | $58,327,500 | -$12,398,925 | 2,525,000 | -18% | Adage Capital Management, L.P. | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 18% | 11,189,693 | 0% | 3.4% | $273,476,097 |
| FMR LLC | 15% | 9,056,062 | +1.9% | 0.01% | $221,330,155 |
| JANUS HENDERSON GROUP PLC | 7.8% | 4,701,112 | +5.4% | 0.05% | $114,988,241 |
| BlackRock, Inc. | 6.2% | 3,730,994 | +9.6% | 0% | $91,185,492 |
| Paradigm Biocapital Advisors LP | 4.8% | 2,920,258 | 0% | 2.1% | $71,371,106 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4.6% | 2,775,000 | +9.9% | 0.11% | $67,821,000 |
| VANGUARD GROUP INC | 4% | 2,417,104 | +10% | 0% | $59,074,022 |
| STATE STREET CORP | 3.1% | 1,891,465 | +36% | 0% | $46,227,405 |
| ORBIMED ADVISORS LLC | 2.9% | 1,766,100 | +46% | 1% | $43,163,484 |
| Point72 Asset Management, L.P. | 2.8% | 1,710,200 | -20% | 0.09% | $41,797,288 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.1% | 1,265,556 | -29% | 0% | $30,931,000 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.8% | 1,083,864 | +20% | 0% | $26,494,551 |
| Woodline Partners LP | 1.7% | 1,026,938 | -17% | 0.12% | $25,098,365 |
| T. Rowe Price Investment Management, Inc. | 1.6% | 972,691 | 0.01% | $23,773,000 | |
| READYSTATE ASSET MANAGEMENT LP | 1.6% | 960,379 | +38% | 1.1% | $23,471,663 |
| Logos Global Management LP | 1.5% | 935,000 | -6.5% | 2.3% | $22,851,400 |
| FRANKLIN RESOURCES INC | 1.5% | 887,755 | -17% | 0.01% | $21,696,730 |
| Prosight Management, LP | 1.4% | 865,350 | +1.3% | 5.1% | $21,149,154 |
| Cormorant Asset Management, LP | 1.4% | 850,000 | -43% | 1.4% | $20,774,000 |
| CITADEL ADVISORS LLC | 1.3% | 802,784 | -35% | 0.02% | $19,620,041 |
| WELLINGTON MANAGEMENT GROUP LLP | 1.2% | 701,604 | +42% | 0% | $17,147,203 |
| TANG CAPITAL MANAGEMENT LLC | 1.2% | 700,000 | +250% | 0.66% | $17,108,000 |
| GOLDMAN SACHS GROUP INC | 1.1% | 655,108 | +88% | 0% | $16,010,840 |
| First Turn Management, LLC | 1.1% | 639,699 | +43% | 2.3% | $15,634,244 |
| MPM BIOIMPACT LLC | 1% | 614,282 | 0% | 2.5% | $15,013,052 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 137,263 | $1,893,755 | +$722,531 | 1,379.78% | 4 |
| 2025 Q3 | 65,054,632 | $1,589,759,767 | -$4,062,602 | 2,444% | 168 |
| 2025 Q2 | 65,439,458 | $1,512,559,459 | -$28,053,955 | 2,310% | 170 |
| 2025 Q1 | 66,482,123 | $1,805,569,824 | -$17,648,986 | 2,700% | 179 |
| 2024 Q4 | 64,084,597 | $3,430,545,581 | +$1,001,929,533 | 5,354% | 212 |
| 2024 Q3 | 45,615,125 | $2,072,053,932 | +$42,307,800 | 4,543% | 159 |
| 2024 Q2 | 44,686,145 | $1,871,580,292 | +$107,868,313 | 4,189% | 152 |
| 2024 Q1 | 42,316,581 | $1,593,195,886 | +$331,813,195 | 3,765% | 118 |
| 2023 Q4 | 33,501,695 | $359,539,783 | -$17,708,423 | 1,073% | 64 |
| 2023 Q3 | 35,112,124 | $353,984,330 | +$43,869,870 | 1,008% | 57 |
| 2023 Q2 | 30,508,831 | $362,117,364 | -$1,132,271 | 1,187% | 54 |
| 2023 Q1 | 30,541,873 | $369,527,635 | +$18,630,246 | 1,210% | 48 |
| 2022 Q4 | 28,953,942 | $381,307,339 | -$7,757,462 | 1,317% | 48 |
| 2022 Q3 | 29,548,315 | $400,091,845 | +$8,915,494 | 1,354.01% | 44 |
| 2022 Q2 | 28,858,606 | $352,314,471 | +$6,490,678 | 1,221.01% | 39 |
| 2022 Q1 | 28,347,360 | $406,524,023 | +$10,925,775 | 1,434% | 45 |
| 2021 Q4 | 27,488,754 | $541,465,745 | +$19,103,046 | 1,972.99% | 45 |
| 2021 Q3 | 26,499,162 | $571,210,440 | +$36,904,313 | 2,163.06% | 45 |
| 2021 Q2 | 24,743,246 | $614,461,000 | +$614,460,518 | 2,495% | 29 |