| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 9.9% | $52.1M | 4.94M | TANG CAPITAL MANAGEMENT, LLC | Mar 31, 2025 | |||
| Frazier Life Sciences Public Fund, L.P. | 6.9% | +42% | $42.2M | $13M | 3.47M | +44.4% | Frazier Life Sciences Public Fund, L.P. | Nov 1, 2025 |
| Capital World Investors | 6.4% | $33.5M | 3.18M | Capital World Investors | Mar 31, 2025 | |||
| MILLENNIUM MANAGEMENT LLC | 5% | $30.8M | 2.53M | Millennium Management LLC | Nov 4, 2025 | |||
| Vestal Point Capital, LP | 1.5% | $9.14M | 750K | Vestal Point Capital, LP | Sep 30, 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 58.6M | $714M | +$51.9M | $12.18 | 142 |
| 2025 Q2 | 54.4M | $616M | -$5.35M | $11.31 | 138 |
| 2025 Q1 | 54.9M | $634M | +$5.36M | $11.54 | 127 |
| 2024 Q4 | 55.2M | $467M | +$30.4M | $8.47 | 129 |
| 2024 Q3 | 48.4M | $561M | +$550K | $11.58 | 120 |
| 2024 Q2 | 48.2M | $568M | +$14.3M | $11.78 | 118 |
| 2024 Q1 | 47M | $557M | +$118M | $11.86 | 127 |
| 2023 Q4 | 12.5K | $154K | -$71.6K | $12.25 | 1 |
| 2023 Q3 | 36.3M | $349M | +$17.9M | $9.63 | 101 |
| 2023 Q2 | 34.5M | $310M | +$8.86M | $9.00 | 93 |
| 2023 Q1 | 33.7M | $265M | -$7.3M | $7.86 | 87 |
| 2022 Q4 | 33.8M | $229M | +$23.5M | $6.76 | 88 |
| 2022 Q3 | 25.6M | $371M | +$16.6M | $14.51 | 85 |
| 2022 Q2 | 24.2M | $238M | -$18.1M | $9.84 | 83 |
| 2022 Q1 | 23.9M | $352M | +$6.71M | $14.74 | 79 |
| 2021 Q4 | 23.8M | $315M | -$24.2M | $13.23 | 93 |
| 2021 Q3 | 23.4M | $408M | -$21.5M | $17.45 | 101 |
| 2021 Q2 | 24.2M | $581M | +$10.8M | $23.96 | 108 |
| 2021 Q1 | 23.5M | $604M | +$242M | $25.69 | 114 |
| 2020 Q4 | 14.6M | $278M | +$4.58M | $18.99 | 78 |
| 2020 Q3 | 15.6M | $197M | +$2.83M | $12.59 | 60 |
| 2020 Q2 | 16M | $194M | +$9.42M | $12.10 | 72 |
| 2020 Q1 | 15.6M | $120M | +$17.3M | $7.65 | 67 |
| 2019 Q4 | 13.7M | $244M | +$13.4M | $17.81 | 71 |
| 2019 Q3 | 13.2M | $153M | -$34M | $11.60 | 74 |
| 2019 Q2 | 14.8M | $327M | +$6.26M | $22.15 | 73 |
| 2019 Q1 | 13.9M | $398M | +$23.8M | $28.62 | 67 |
| 2018 Q4 | 13M | $256M | +$10.7M | $19.75 | 55 |
| 2018 Q3 | 12.3M | $271M | +$111M | $22.11 | 46 |
| 2018 Q2 | 6.32M | $51.3M | -$1.58M | $8.12 | 24 |
| 2018 Q1 | 6.5M | $61.6M | +$134K | $9.48 | 22 |
| 2017 Q4 | 6.48M | $63.2M | -$3M | $9.75 | 22 |
| 2017 Q3 | 7.72M | $52.2M | +$2.31M | $6.73 | 15 |
| 2017 Q2 | 7.37M | $54.1M | -$1.77M | $7.36 | 16 |
| 2017 Q1 | 7.59M | $59.2M | +$2.02M | $7.81 | 17 |
| 2016 Q4 | 7.33M | $51.5M | +$47M | $7.07 | 18 |