| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 9.9% | $52,086,551 | 4,941,798 | TANG CAPITAL MANAGEMENT, LLC | 31 Mar 2025 | |||
| Frazier Life Sciences Public Fund, L.P. | 6.9% | +42% | $42,222,226 | +$12,986,864 | 3,466,521 | +44% | Frazier Life Sciences Public Fund, L.P. | 01 Nov 2025 |
| Capital World Investors | 6.4% | $33,491,767 | 3,177,587 | Capital World Investors | 31 Mar 2025 | |||
| MILLENNIUM MANAGEMENT LLC | 5.9% | +18% | $39,595,019 | +$5,780,725 | 2,963,699 | +17% | Millennium Management LLC | 23 Dec 2025 |
| Vestal Point Capital, LP | 1.5% | $9,135,000 | 750,000 | Vestal Point Capital, LP | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| VR ADVISER, LLC | 13% | 6,728,985 | 0% | 4.6% | $81,959,037 |
| TANG CAPITAL MANAGEMENT LLC | 10% | 5,041,798 | +2% | 2.4% | $61,409,100 |
| Frazier Life Sciences Management, L.P. | 10% | 5,039,867 | +3.1% | 1.8% | $61,385,580 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 9.5% | 4,768,712 | -3.8% | 1.8% | $58,082,912 |
| Capital World Investors | 6.3% | 3,177,587 | 0% | 0.01% | $38,703,010 |
| BlackRock, Inc. | 6.2% | 3,126,117 | -0.11% | 0% | $38,076,105 |
| VANGUARD GROUP INC | 5% | 2,501,119 | +3.7% | 0% | $30,463,629 |
| MILLENNIUM MANAGEMENT LLC | 4.2% | 2,096,223 | +515% | 0.02% | $25,531,996 |
| Woodline Partners LP | 3.8% | 1,920,664 | 0% | 0.11% | $23,393,688 |
| GOLDMAN SACHS GROUP INC | 3.6% | 1,800,181 | +1239% | 0% | $21,926,205 |
| Parkman Healthcare Partners LLC | 3.5% | 1,735,003 | +155% | 2.3% | $21,132,337 |
| STATE STREET CORP | 3.1% | 1,575,496 | +17% | 0% | $19,189,541 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2.7% | 1,363,378 | -26% | 2.4% | $16,605,944 |
| EMERALD ADVISERS, LLC | 2.7% | 1,351,254 | +30% | 0.53% | $16,458,274 |
| Octagon Capital Advisors LP | 2.5% | 1,273,333 | 0% | 2.4% | $15,509,196 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 2.3% | 1,158,457 | +109% | 0.01% | $14,144,760 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.8% | 928,671 | -1.3% | 0% | $11,313,517 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1.8% | 917,975 | +19% | 0.58% | $11,180,936 |
| Vestal Point Capital, LP | 1.5% | 750,000 | -84% | 0.41% | $9,135,000 |
| Freestone Grove Partners LP | 1.4% | 704,448 | 0.06% | $8,580,177 | |
| Sio Capital Management, LLC | 1.4% | 683,819 | 2.1% | $8,328,915 | |
| Kynam Capital Management, LP | 1.2% | 606,171 | 0.55% | $7,383,163 | |
| Bank of New York Mellon Corp | 1.2% | 596,474 | +454% | 0% | $7,265,054 |
| BARCLAYS PLC | 1.2% | 577,904 | +242% | 0% | $7,038,871 |
| MORGAN STANLEY | 1.1% | 564,855 | +136% | 0% | $6,879,937 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 60,203 | $972,595 | +$275,917 | $16.15 | 5 |
| 2025 Q3 | 58,631,944 | $714,167,714 | +$51,926,504 | $12.18 | 143 |
| 2025 Q2 | 54,445,883 | $615,513,091 | -$5,352,598 | $11.30 | 138 |
| 2025 Q1 | 54,890,685 | $633,782,168 | +$5,364,855 | $11.54 | 127 |
| 2024 Q4 | 55,190,249 | $467,414,125 | +$30,397,004 | $8.47 | 129 |
| 2024 Q3 | 48,412,221 | $560,958,386 | +$550,126 | $11.58 | 120 |
| 2024 Q2 | 48,235,227 | $568,211,500 | +$14,329,311 | $11.78 | 118 |
| 2024 Q1 | 46,977,159 | $557,147,902 | +$118,361,057 | $11.86 | 127 |
| 2023 Q4 | 12,539 | $153,603 | -$71,643 | $12.25 | 1 |
| 2023 Q3 | 36,263,336 | $349,220,972 | +$17,907,372 | $9.63 | 101 |
| 2023 Q2 | 34,451,516 | $310,062,975 | +$8,856,436 | $9.00 | 93 |
| 2023 Q1 | 33,720,468 | $265,038,656 | -$7,296,084 | $7.86 | 87 |
| 2022 Q4 | 33,810,837 | $228,557,377 | +$23,549,943 | $6.76 | 88 |
| 2022 Q3 | 25,554,803 | $370,795,783 | +$16,611,402 | $14.51 | 85 |
| 2022 Q2 | 24,193,911 | $238,066,172 | -$18,124,235 | $9.84 | 83 |
| 2022 Q1 | 23,880,152 | $352,009,504 | +$6,707,292 | $14.74 | 79 |
| 2021 Q4 | 23,784,064 | $314,614,009 | -$24,155,323 | $13.23 | 93 |
| 2021 Q3 | 23,367,778 | $408,011,803 | -$21,469,346 | $17.45 | 101 |
| 2021 Q2 | 24,234,176 | $580,656,986 | +$10,755,666 | $23.96 | 108 |
| 2021 Q1 | 23,504,825 | $603,806,034 | +$241,535,569 | $25.69 | 114 |
| 2020 Q4 | 14,627,574 | $277,764,932 | +$4,583,782 | $18.99 | 78 |
| 2020 Q3 | 15,642,000 | $196,878,450 | +$2,825,299 | $12.59 | 60 |
| 2020 Q2 | 15,986,858 | $193,667,544 | +$9,418,795 | $12.10 | 72 |
| 2020 Q1 | 15,622,520 | $119,504,221 | +$17,285,176 | $7.65 | 67 |
| 2019 Q4 | 13,678,308 | $243,587,076 | +$13,387,676 | $17.81 | 71 |
| 2019 Q3 | 13,183,427 | $152,925,098 | -$33,967,366 | $11.60 | 74 |
| 2019 Q2 | 14,785,410 | $327,483,694 | +$6,255,781 | $22.15 | 73 |
| 2019 Q1 | 13,905,857 | $397,892,000 | +$23,848,401 | $28.62 | 67 |
| 2018 Q4 | 12,995,704 | $256,397,000 | +$10,739,559 | $19.75 | 55 |
| 2018 Q3 | 12,319,459 | $270,617,769 | +$110,908,440 | $22.11 | 46 |
| 2018 Q2 | 6,316,266 | $51,280,000 | -$1,576,548 | $8.12 | 24 |
| 2018 Q1 | 6,502,090 | $61,589,000 | +$133,888 | $9.48 | 22 |
| 2017 Q4 | 6,483,901 | $63,212,000 | -$2,998,186 | $9.75 | 22 |
| 2017 Q3 | 7,715,060 | $52,230,000 | +$2,314,856 | $6.73 | 15 |
| 2017 Q2 | 7,368,296 | $54,073,000 | -$1,766,452 | $7.36 | 16 |
| 2017 Q1 | 7,587,249 | $59,160,000 | +$2,023,036 | $7.81 | 17 |
| 2016 Q4 | 7,331,083 | $51,493,000 | +$46,973,881 | $7.07 | 18 |