| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BIOTECHNOLOGY VALUE FUND L P | 9.99% | +31.1% | $76.8M | $24.5M | 8.68M | +46.8% | BVF PARTNERS L P/IL | Sep 30, 2025 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 9.4% | +38.6% | $45.1M | $14.1M | 7.56M | +45.5% | SUVRETTA CAPITAL MANAGEMENT, LLC | Mar 31, 2025 |
| BlackRock, Inc. | 7.8% | -24% | $37.8M | -$9.58M | 6.33M | -20.2% | BlackRock, Inc. | Mar 31, 2025 |
| ARMISTICE CAPITAL, LLC | 5.37% | -27.8% | $41.3M | -$16.8M | 4.67M | -28.9% | Armistice Capital, LLC | Sep 30, 2025 |
| EcoR1 Capital, LLC | 4.8% | $25.3M | 4.2M | EcoR1 Capital, LLC | Jun 30, 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 4.9% | $23.9M | 4M | RA Capital Management, L.P. | Mar 31, 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 83.9M | $742M | +$27.2M | $8.85 | 197 |
| 2025 Q2 | 82.2M | $474M | +$3.89M | $5.77 | 180 |
| 2025 Q1 | 80.5M | $531M | -$1.74M | $6.60 | 183 |
| 2024 Q4 | 78.8M | $686M | -$218M | $8.71 | 184 |
| 2024 Q3 | 82.4M | $1.61B | +$3.96M | $19.54 | 178 |
| 2024 Q2 | 80.5M | $1.66B | -$4.36M | $20.59 | 173 |
| 2024 Q1 | 80.7M | $1.72B | +$49.5M | $21.33 | 163 |
| 2023 Q4 | 40.2K | $577K | -$446K | $14.35 | 2 |
| 2023 Q3 | 75.2M | $685M | -$2.89M | $9.12 | 129 |
| 2023 Q2 | 75.1M | $795M | +$20.1M | $10.58 | 146 |
| 2023 Q1 | 72.4M | $885M | +$27.5M | $12.23 | 139 |
| 2022 Q4 | 70.1M | $870M | -$24.8M | $12.41 | 137 |
| 2022 Q3 | 71.5M | $977M | -$9.87M | $13.66 | 139 |
| 2022 Q2 | 68.6M | $1.26B | +$54.2M | $18.33 | 140 |
| 2022 Q1 | 64.7M | $1.04B | +$41.7M | $16.08 | 137 |
| 2021 Q4 | 62M | $869M | -$106M | $14.00 | 137 |
| 2021 Q3 | 65.7M | $1.23B | -$23.4M | $18.73 | 147 |
| 2021 Q2 | 66.6M | $1.39B | -$37.9M | $20.85 | 162 |
| 2021 Q1 | 68.5M | $1.94B | +$125M | $28.27 | 160 |
| 2020 Q4 | 62.5M | $2.04B | +$339M | $32.66 | 184 |
| 2020 Q3 | 53.1M | $1.63B | +$43.2M | $30.64 | 157 |
| 2020 Q2 | 52.2M | $851M | +$209M | $16.30 | 125 |
| 2020 Q1 | 39.6M | $393M | +$5.32M | $9.95 | 111 |
| 2019 Q4 | 38.8M | $533M | -$12.8M | $13.75 | 123 |
| 2019 Q3 | 39.2M | $595M | +$25.3M | $15.17 | 111 |
| 2019 Q2 | 37.3M | $734M | +$138M | $19.69 | 119 |
| 2019 Q1 | 30.4M | $504M | +$1.16M | $16.59 | 96 |
| 2018 Q4 | 30.5M | $428M | -$2.84M | $14.04 | 92 |
| 2018 Q3 | 30.1M | $527M | +$9.42M | $17.50 | 109 |
| 2018 Q2 | 29.7M | $538M | +$109M | $18.20 | 107 |
| 2018 Q1 | 23.5M | $440M | +$77.1M | $18.75 | 96 |
| 2017 Q4 | 18M | $275M | -$7.19M | $15.30 | 71 |
| 2017 Q3 | 19.2M | $287M | +$127M | $14.95 | 63 |
| 2017 Q2 | 10.8M | $101M | +$4.77M | $9.30 | 42 |
| 2017 Q1 | 10.3M | $90.7M | +$4.18M | $8.80 | 34 |
| 2016 Q4 | 9.88M | $58.2M | +$735K | $5.90 | 29 |
| 2016 Q3 | 9.75M | $60.9M | +$2.8M | $6.25 | 26 |
| 2016 Q2 | 9.32M | $25.2M | -$2.97M | $2.71 | 25 |
| 2016 Q1 | 10.2M | $40.7M | -$957K | $4.05 | 19 |
| 2015 Q4 | 10.2M | $86.1M | +$80.3M | $8.40 | 14 |