| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BIOTECHNOLOGY VALUE FUND L P | 10% | +31% | $76,791,609 | +$24,465,506 | 8,677,018 | +47% | BVF PARTNERS L P/IL | 30 Sep 2025 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 9.4% | +39% | $45,139,170 | +$14,105,982 | 7,561,000 | +45% | SUVRETTA CAPITAL MANAGEMENT, LLC | 31 Mar 2025 |
| BlackRock, Inc. | 7.8% | -24% | $37,784,428 | -$9,582,172 | 6,329,050 | -20% | BlackRock, Inc. | 31 Mar 2025 |
| ARMISTICE CAPITAL, LLC | 5.4% | -28% | $41,347,200 | -$16,815,000 | 4,672,000 | -29% | Armistice Capital, LLC | 30 Sep 2025 |
| EcoR1 Capital, LLC | 4.8% | $25,284,000 | 4,200,000 | EcoR1 Capital, LLC | 30 Jun 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 4.9% | $23,907,522 | 4,004,610 | RA Capital Management, L.P. | 31 Mar 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| BlackRock, Inc. | 11% | 9,515,135 | +0.47% | 0% | $84,208,945 |
| BVF INC/IL | 9.9% | 8,617,162 | +11% | 3.1% | $76,261,884 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 9.3% | 8,116,000 | 0% | 2.2% | $71,826,600 |
| VANGUARD GROUP INC | 6.3% | 5,468,522 | +2.2% | 0% | $48,396,420 |
| ARMISTICE CAPITAL, LLC | 5.4% | 4,672,000 | -25% | 1.3% | $41,347,200 |
| STATE STREET CORP | 3.8% | 3,343,131 | +10% | 0% | $29,586,709 |
| Prosight Management, LP | 3.2% | 2,758,516 | -13% | 5.9% | $24,412,867 |
| GOLDMAN SACHS GROUP INC | 3% | 2,614,726 | +180% | 0% | $23,140,325 |
| AQR CAPITAL MANAGEMENT LLC | 2.6% | 2,242,192 | +138% | 0.01% | $19,843,399 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 2.6% | 2,224,590 | +102% | 0.08% | $19,687,622 |
| MILLENNIUM MANAGEMENT LLC | 2.4% | 2,093,702 | -20% | 0.01% | $18,529,263 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.4% | 2,047,926 | +1.7% | 0% | $18,127,511 |
| MORGAN STANLEY | 2.1% | 1,813,064 | -8.6% | 0% | $16,045,621 |
| Qube Research & Technologies Ltd | 2% | 1,712,716 | -10% | 0.02% | $15,157,537 |
| ALETHEA CAPITAL MANAGEMENT, LLC | 1.6% | 1,388,794 | +46% | 7.9% | $12,290,827 |
| Assenagon Asset Management S.A. | 1.5% | 1,265,030 | +38% | 0.02% | $11,195,516 |
| DIMENSIONAL FUND ADVISORS LP | 1.3% | 1,139,365 | -8.3% | 0% | $10,083,861 |
| ACADIAN ASSET MANAGEMENT LLC | 1.2% | 1,060,829 | +22% | 0.02% | $9,387,000 |
| ALGERT GLOBAL LLC | 1.2% | 1,011,945 | -5.4% | 0.15% | $8,956,000 |
| EcoR1 Capital, LLC | 1% | 872,500 | -79% | 0.37% | $7,721,625 |
| RENAISSANCE TECHNOLOGIES LLC | 0.99% | 865,310 | -18% | 0.01% | $7,657,994 |
| CITADEL ADVISORS LLC | 0.93% | 808,818 | +122% | 0.01% | $7,158,040 |
| NORTHERN TRUST CORP | 0.87% | 753,600 | +8.6% | 0% | $6,669,361 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.82% | 711,896 | +1.8% | 0% | $6,300,280 |
| AMERICAN CENTURY COMPANIES INC | 0.77% | 669,046 | +187% | 0% | $5,921,057 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 140,663 | $1,344,895 | +$141,976 | $10.39 | 6 |
| 2025 Q3 | 83,953,188 | $743,091,012 | +$26,560,569 | $8.85 | 198 |
| 2025 Q2 | 82,161,271 | $474,076,451 | +$3,886,066 | $5.77 | 180 |
| 2025 Q1 | 80,481,583 | $531,240,618 | -$1,740,529 | $6.60 | 183 |
| 2024 Q4 | 78,799,607 | $686,298,457 | -$217,678,180 | $8.71 | 184 |
| 2024 Q3 | 82,360,607 | $1,606,956,737 | +$3,955,490 | $19.54 | 178 |
| 2024 Q2 | 80,464,005 | $1,656,732,694 | -$4,363,479 | $20.59 | 173 |
| 2024 Q1 | 80,692,487 | $1,721,138,041 | +$49,498,569 | $21.33 | 163 |
| 2023 Q4 | 40,159 | $576,716 | -$446,397 | $14.34 | 2 |
| 2023 Q3 | 75,153,989 | $685,383,981 | -$2,892,869 | $9.12 | 129 |
| 2023 Q2 | 75,132,461 | $794,961,873 | +$20,118,037 | $10.58 | 146 |
| 2023 Q1 | 72,441,228 | $885,154,794 | +$27,485,946 | $12.23 | 139 |
| 2022 Q4 | 70,128,598 | $870,155,639 | -$24,769,337 | $12.41 | 137 |
| 2022 Q3 | 71,548,279 | $977,310,285 | -$9,868,000 | $13.66 | 139 |
| 2022 Q2 | 68,634,915 | $1,258,068,611 | +$54,229,438 | $18.33 | 140 |
| 2022 Q1 | 64,650,945 | $1,039,489,952 | +$41,719,245 | $16.08 | 137 |
| 2021 Q4 | 62,025,343 | $868,581,054 | -$106,142,238 | $14.00 | 137 |
| 2021 Q3 | 65,734,221 | $1,231,218,263 | -$23,395,246 | $18.73 | 147 |
| 2021 Q2 | 66,615,329 | $1,388,931,935 | -$37,869,506 | $20.85 | 162 |
| 2021 Q1 | 68,451,675 | $1,938,731,592 | +$124,746,977 | $28.27 | 160 |
| 2020 Q4 | 62,518,041 | $2,042,133,962 | +$338,978,921 | $32.66 | 184 |
| 2020 Q3 | 53,148,772 | $1,628,424,751 | +$43,228,140 | $30.64 | 157 |
| 2020 Q2 | 52,176,126 | $851,151,913 | +$209,126,635 | $16.30 | 125 |
| 2020 Q1 | 39,615,341 | $392,701,391 | +$5,317,694 | $9.95 | 111 |
| 2019 Q4 | 38,791,574 | $533,386,217 | -$12,767,491 | $13.75 | 123 |
| 2019 Q3 | 39,227,572 | $595,018,193 | +$25,301,338 | $15.17 | 111 |
| 2019 Q2 | 37,287,112 | $734,201,288 | +$137,666,395 | $19.69 | 119 |
| 2019 Q1 | 30,403,832 | $503,898,947 | +$1,160,808 | $16.59 | 96 |
| 2018 Q4 | 30,498,627 | $427,879,020 | -$2,835,798 | $14.04 | 92 |
| 2018 Q3 | 30,139,808 | $527,471,625 | +$9,418,981 | $17.50 | 109 |
| 2018 Q2 | 29,713,906 | $537,504,780 | +$109,387,451 | $18.20 | 107 |
| 2018 Q1 | 23,486,848 | $440,365,325 | +$77,107,009 | $18.75 | 96 |
| 2017 Q4 | 18,003,680 | $275,443,651 | -$7,194,972 | $15.30 | 71 |
| 2017 Q3 | 19,217,641 | $287,261,810 | +$126,558,545 | $14.95 | 63 |
| 2017 Q2 | 10,813,395 | $100,551,904 | +$4,770,964 | $9.30 | 42 |
| 2017 Q1 | 10,310,503 | $90,718,000 | +$4,182,421 | $8.80 | 34 |
| 2016 Q4 | 9,877,148 | $58,241,000 | +$735,497 | $5.90 | 29 |
| 2016 Q3 | 9,749,053 | $60,932,000 | +$2,799,335 | $6.25 | 26 |
| 2016 Q2 | 9,319,042 | $25,248,000 | -$2,970,812 | $2.71 | 25 |
| 2016 Q1 | 10,225,108 | $40,701,709 | -$957,342 | $4.05 | 19 |
| 2015 Q4 | 10,246,869 | $86,073,000 | +$80,323,987 | $8.40 | 14 |