| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 11% | +38% | $694,720,745 | +$237,235,847 | 8,928,574 | +52% | FMR LLC | 31 Dec 2025 |
| BAKER BROS. ADVISORS LP | 11% | +14% | $569,111,115 | +$131,852,757 | 8,676,797 | +30% | Baker Bros. Advisors LP | 09 Dec 2025 |
| BIOTECHNOLOGY VALUE FUND L P | 8.5% | $450,459,592 | 6,867,809 | BVF PARTNERS L P/IL | 11 Dec 2025 | |||
| WELLINGTON MANAGEMENT GROUP LLP | 7.7% | -17% | $234,436,742 | -$27,266,796 | 5,372,061 | -10% | Wellington Management Group LLP | 30 Jun 2025 |
| VANGUARD GROUP INC | 8% | $117,183,181 | 5,231,392 | The Vanguard Group | 31 Mar 2025 | |||
| PRICE T ROWE ASSOCIATES INC /MD/ | 7.1% | $288,530,046 | 5,097,704 | T. Rowe Price Associates, Inc. | 30 Sep 2025 | |||
| BlackRock, Inc. | 5.4% | $122,349,813 | 3,803,227 | BlackRock, Inc. | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 8.3% | 6,651,429 | 0% | 2.7% | $376,470,881 |
| Avoro Capital Advisors LLC | 8% | 6,350,000 | -3.1% | 4.6% | $359,410,000 |
| FMR LLC | 7.4% | 5,879,611 | +8.2% | 0.02% | $332,785,989 |
| BVF INC/IL | 6.9% | 5,502,710 | 0% | 13% | $311,453,386 |
| VANGUARD GROUP INC | 6.8% | 5,421,722 | -3.5% | 0% | $306,869,465 |
| WELLINGTON MANAGEMENT GROUP LLP | 6.5% | 5,195,691 | -3.3% | 0.05% | $294,076,110 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6.4% | 5,097,378 | -26% | 0.03% | $288,513,000 |
| Atlas Venture Life Science Advisors, LLC | 6.1% | 4,896,462 | 0% | 37% | $277,139,749 |
| BlackRock, Inc. | 5.5% | 4,365,448 | +5.2% | 0% | $247,084,359 |
| Siren, L.L.C. | 4.3% | 3,428,150 | 0% | 7.6% | $194,033,290 |
| STATE STREET CORP | 2.5% | 2,019,454 | +30% | 0% | $114,301,096 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.6% | 1,276,766 | +7% | 0% | $72,276,364 |
| Capital Research Global Investors | 1.6% | 1,262,182 | 0% | 0.01% | $71,439,501 |
| JENNISON ASSOCIATES LLC | 1.3% | 1,027,739 | +25% | 0.03% | $58,170,027 |
| Driehaus Capital Management LLC | 1.2% | 939,094 | +0.56% | 0.38% | $53,152,720 |
| UBS AM, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS LLC | 1.1% | 863,762 | +5.5% | 0.01% | $48,888,930 |
| Holocene Advisors, LP | 1.1% | 840,333 | 0.11% | $47,562,848 | |
| Merck & Co., Inc. | 0.97% | 772,165 | 0% | 19% | $43,704,539 |
| Commodore Capital LP | 0.94% | 750,000 | 0% | 2.1% | $42,450,000 |
| DIMENSIONAL FUND ADVISORS LP | 0.92% | 731,420 | +30% | 0.01% | $41,409,153 |
| GOLDMAN SACHS GROUP INC | 0.89% | 711,444 | +155% | 0.01% | $40,267,730 |
| UBS Group AG | 0.81% | 648,718 | +16% | 0.01% | $36,717,439 |
| EVENTIDE ASSET MANAGEMENT, LLC | 0.81% | 644,590 | +14% | 0.6% | $36,483,859 |
| Alyeska Investment Group, L.P. | 0.77% | 615,091 | +1130% | 0.11% | $34,814,151 |
| T. Rowe Price Investment Management, Inc. | 0.77% | 611,221 | +574% | 0.02% | $34,596,000 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 22,991 | $1,789,187 | +$1,119,693 | 7,781.51% | 2 |
| 2025 Q3 | 80,867,584 | $4,576,968,145 | +$137,544,818 | 5,660% | 206 |
| 2025 Q2 | 78,801,090 | $3,438,767,375 | +$270,834,411 | 4,364% | 209 |
| 2025 Q1 | 72,808,716 | $1,995,262,892 | +$5,348,220 | 2,737% | 171 |
| 2024 Q4 | 71,734,044 | $2,885,597,297 | +$18,569,333 | 4,023% | 177 |
| 2024 Q3 | 68,960,007 | $3,264,074,987 | -$2,272,100 | 4,733% | 173 |
| 2024 Q2 | 67,394,647 | $2,011,764,703 | +$10,124,429 | 2,985% | 153 |
| 2024 Q1 | 67,081,234 | $2,696,673,715 | +$295,861,006 | 4,020% | 159 |
| 2023 Q4 | 224,963 | $5,764,278 | +$3,181,685 | 2,546.01% | 4 |
| 2023 Q3 | 57,205,249 | $795,164,056 | -$17,579,562 | 1,390% | 118 |
| 2023 Q2 | 58,035,560 | $1,334,220,622 | +$24,134,659 | 2,299% | 121 |
| 2023 Q1 | 56,830,949 | $1,682,653,801 | +$23,240,441 | 2,963% | 121 |
| 2022 Q4 | 56,095,964 | $1,400,212,729 | +$97,828,650 | 2,496% | 114 |
| 2022 Q3 | 51,020,711 | $1,110,776,844 | +$28,026,304 | 2,177% | 114 |
| 2022 Q2 | 49,240,285 | $969,113,847 | +$11,517,000 | 1,968.99% | 97 |
| 2022 Q1 | 45,260,761 | $1,915,201,786 | +$61,683,351 | 4,232% | 124 |
| 2021 Q4 | 43,134,018 | $2,737,370,438 | +$117,402,785 | 6,349% | 122 |
| 2021 Q3 | 34,293,472 | $2,014,883,491 | +$486,024,539 | 5,874% | 113 |
| 2021 Q2 | 26,536,322 | $1,287,767,574 | +$190,156,234 | 4,850% | 109 |
| 2021 Q1 | 22,820,749 | $886,801,865 | +$90,209,096 | 3,886% | 94 |
| 2020 Q4 | 20,039,060 | $1,230,826,136 | +$52,330,949 | 6,200% | 72 |
| 2020 Q3 | 16,362,026 | $527,472,000 | +$527,472,105 | 3,231% | 50 |