| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Flynn James E | 36% | $82,495,505 | 30,667,474 | Deerfield Management Company, L.P. | 31 Jul 2025 | |||
| MILLENNIUM MANAGEMENT LLC | 5.8% | +3.3% | $16,043,858 | +$4,532,710 | 4,966,831 | +39% | Millennium Management LLC | 30 Sep 2025 |
| Opaleye Management Inc. | 4.8% | -23% | $16,029,000 | +$614,605 | 4,110,000 | +4% | Opaleye Management, Inc. | 29 Aug 2025 |
| BlackRock, Inc. | 4.8% | -6% | $5,266,227 | -$318,470 | 3,079,665 | -5.7% | BlackRock, Inc. | 31 Mar 2025 |
| GOLDMAN SACHS GROUP INC | 4.1% | $4,446,361 | 2,600,211 | THE GOLDMAN SACHS GROUP, INC. | 31 Mar 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 36% | 30,606,974 | +44% | 1.5% | $98,860,526 |
| RA CAPITAL MANAGEMENT, L.P. | 7.1% | 6,045,351 | 0% | 0.24% | $19,526,484 |
| Blue Owl Capital Holdings LP | 6.8% | 5,853,040 | +19% | 5.9% | $18,905,319 |
| MILLENNIUM MANAGEMENT LLC | 5.7% | 4,896,831 | +34% | 0.01% | $15,816,764 |
| Opaleye Management Inc. | 4.3% | 3,720,867 | -9.5% | 1.5% | $10,564,900 |
| BlackRock, Inc. | 3.9% | 3,339,192 | +9.8% | 0% | $10,785,590 |
| RTW INVESTMENTS, LP | 3.6% | 3,125,000 | 0.12% | $10,093,750 | |
| VANGUARD GROUP INC | 3.6% | 3,087,840 | +44% | 0% | $9,973,723 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2.2% | 1,900,000 | 0.01% | $6,137,000 | |
| Alyeska Investment Group, L.P. | 2.2% | 1,887,169 | -9.1% | 0.02% | $6,095,556 |
| Woodline Partners LP | 1.9% | 1,622,850 | +161% | 0.02% | $5,241,806 |
| GOLDMAN SACHS GROUP INC | 1.8% | 1,575,001 | +1097% | 0% | $5,087,254 |
| CITADEL ADVISORS LLC | 1.7% | 1,477,506 | +11% | 0% | $4,772,344 |
| Caption Management, LLC | 1.5% | 1,312,352 | +90% | 0.25% | $4,238,897 |
| Point72 Asset Management, L.P. | 1.4% | 1,223,866 | 0.01% | $3,953,087 | |
| DAFNA Capital Management LLC | 1.2% | 1,027,764 | +177% | 0.82% | $3,319,678 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.2% | 1,022,527 | +13% | 0% | $3,303,366 |
| AIGH Capital Management LLC | 1.2% | 1,000,000 | 1.1% | $3,230,000 | |
| STATE STREET CORP | 1% | 891,869 | +3.8% | 0% | $2,880,737 |
| RENAISSANCE TECHNOLOGIES LLC | 1% | 858,642 | +53% | 0% | $2,773,414 |
| Verition Fund Management LLC | 0.66% | 567,683 | 0% | 0.01% | $1,833,616 |
| AQR CAPITAL MANAGEMENT LLC | 0.66% | 562,403 | +31% | 0% | $1,816,561 |
| Driehaus Capital Management LLC | 0.63% | 535,464 | 0% | 0.01% | $1,729,549 |
| MANGROVE PARTNERS IM, LLC | 0.52% | 442,236 | -43% | 0.11% | $1,428,422 |
| JANE STREET GROUP, LLC | 0.49% | 422,712 | +3913% | 0% | $1,365,359 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 74,830 | $278,198 | +$55,782 | $3.81 | 5 |
| 2025 Q3 | 85,510,151 | $274,838,015 | +$75,245,037 | $3.23 | 136 |
| 2025 Q2 | 62,321,311 | $180,120,860 | +$7,437,019 | $2.89 | 116 |
| 2025 Q1 | 60,827,153 | $131,863,819 | -$12,271,766 | $2.15 | 101 |
| 2024 Q4 | 63,433,546 | $245,489,139 | -$5,895,216 | $3.87 | 114 |
| 2024 Q3 | 64,329,070 | $421,287,268 | -$5,929,387 | $6.55 | 122 |
| 2024 Q2 | 65,308,462 | $473,379,717 | +$12,179,948 | $7.25 | 105 |
| 2024 Q1 | 63,594,662 | $482,627,215 | +$182,849,088 | $7.59 | 104 |
| 2023 Q4 | 11,473 | $52,202 | $4.55 | 1 | |
| 2023 Q3 | 38,745,394 | $153,032,082 | -$3,457,113 | $3.95 | 63 |
| 2023 Q2 | 39,026,892 | $120,192,442 | -$3,680,276 | $3.13 | 64 |
| 2023 Q1 | 38,462,442 | $174,244,129 | +$995,786 | $4.53 | 68 |
| 2022 Q4 | 38,766,976 | $160,093,910 | +$976,434 | $4.13 | 47 |
| 2022 Q3 | 38,478,464 | $123,144,000 | +$77,837,109 | $3.20 | 49 |
| 2022 Q2 | 14,390,026 | $28,219,000 | -$2,239,611 | $1.96 | 33 |
| 2022 Q1 | 15,257,103 | $61,778,000 | -$5,126,613 | $4.05 | 40 |
| 2021 Q4 | 14,567,185 | $157,169,000 | +$903,281 | $10.79 | 46 |
| 2021 Q3 | 14,425,478 | $166,406,000 | -$883,394 | $11.53 | 50 |
| 2021 Q2 | 14,544,121 | $142,829,000 | -$4,477,669 | $9.82 | 43 |
| 2021 Q1 | 14,110,495 | $206,148,000 | -$8,478,628 | $14.61 | 54 |
| 2020 Q4 | 13,789,632 | $295,230,000 | +$5,240,769 | $21.41 | 40 |
| 2020 Q3 | 13,625,016 | $206,745,000 | +$10,358,995 | $15.17 | 37 |
| 2020 Q2 | 12,917,397 | $165,684,000 | +$165,683,742 | $12.85 | 33 |