| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Third Rock Ventures IV, L.P. | 14% | $47,559,091 | 6,073,958 | Third Rock Ventures IV, L.P. | 31 Jan 2025 | |||
| ARCH Venture Fund X, L.P. | 9.4% | $32,260,015 | 4,120,053 | ARCH Venture Fund X, L.P. | 31 Mar 2025 | |||
| Deep Track Capital, LP | 9% | +30% | $54,771,382 | +$12,835,659 | 3,948,910 | +31% | Deep Track Capital, LP | 30 Jun 2025 |
| Frazier Life Sciences Public Fund, L.P. | 7.7% | -25% | $46,504,931 | -$15,235,141 | 3,352,915 | -25% | Frazier Life Sciences Public Fund, L.P. | 30 Jun 2025 |
| JANUS HENDERSON GROUP PLC | 7.3% | +22% | $83,143,178 | +$15,075,145 | 3,206,472 | +22% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| GV 2019, L.P. | 5.5% | $18,889,648 | 2,412,471 | Alphabet Holdings LLC | 31 Mar 2025 | |||
| Matrix Capital Management Company, LP | 3.5% | -37% | $42,879,695 | -$21,586,558 | 1,653,684 | -33% | Matrix Capital Management Company, LP | 30 Sep 2025 |
| Foresite Capital Fund IV, L.P. | 1.4% | -70% | $15,789,900 | -$47,922,419 | 608,948 | -75% | James Tananbaum | 30 Sep 2025 |
As of 30 Sep 2025, 93 institutional investors reported holding 42,970,633 shares of Maze Therapeutics, Inc. - Common Stock, par value $0.001 (MAZE). This represents 99% of the company’s total 43,496,286 outstanding shares.
The largest institutional shareholders of Maze Therapeutics, Inc. - Common Stock, par value $0.001 (MAZE) together control 90% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| TRV GP IV, LLC | 14% | 6,073,958 | 0% | 57% | $157,497,731 |
| Frazier Life Sciences Management, L.P. | 11% | 4,567,274 | -0% | 3.5% | $118,429,415 |
| ARCH Venture Management, LLC | 9.5% | 4,120,053 | 0% | 22% | $106,832,974 |
| Deep Track Capital, LP | 9.1% | 3,948,910 | 0% | 2.9% | $102,395,236 |
| Alphabet Inc. | 5.5% | 2,412,471 | 0% | 2.6% | $62,555,373 |
| a16z Capital Management, L.L.C. | 3.9% | 1,702,225 | 0% | 3.2% | $44,138,694 |
| Matrix Capital Management Company, LP | 3.8% | 1,653,684 | -33% | 40% | $42,880,026 |
| VANGUARD GROUP INC | 3.1% | 1,334,955 | +218% | 0% | $34,615,383 |
| BlackRock, Inc. | 3% | 1,316,016 | +114% | 0% | $34,124,295 |
| VR ADVISER, LLC | 2.8% | 1,230,769 | 1.8% | $31,913,840 | |
| Logos Global Management LP | 2.8% | 1,227,300 | +101% | 3.1% | $31,823,889 |
| General Catalyst Group Management, LLC | 2.4% | 1,035,910 | 0% | 0.88% | $26,861,146 |
| Woodline Partners LP | 2.4% | 1,035,229 | +10% | 0.13% | $26,843,488 |
| TRV GP V, LLC | 2.2% | 950,800 | 0% | 7% | $24,654,244 |
| MARSHALL WACE, LLP | 1.8% | 777,701 | +3868% | 0.02% | $20,165,786 |
| Casdin Capital, LLC | 1.7% | 758,857 | 0% | 1.6% | $19,677,162 |
| JANUS HENDERSON GROUP PLC | 1.7% | 751,874 | -46% | 0.01% | $19,488,574 |
| Ikarian Capital, LLC | 1.7% | 740,825 | +182% | 4.4% | $19,209,592 |
| FMR LLC | 1.5% | 655,614 | +18% | 0% | $17,000,071 |
| ArrowMark Colorado Holdings LLC | 1.3% | 545,132 | 0.26% | $14,135,273 | |
| Foresite Capital Management IV, LLC | 1.2% | 522,657 | -75% | 7.4% | $13,552,496 |
| BESSEMER GROUP INC | 1.1% | 481,790 | 0% | 0.02% | $12,493,000 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.1% | 473,549 | +105% | 0% | $12,281,796 |
| HHLR ADVISORS, LTD. | 1.1% | 457,535 | 0% | 0.29% | $11,863,883 |
| Balyasny Asset Management L.P. | 1% | 433,725 | 0.02% | $11,246,489 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 289,676 | $12,001,413 | +$3,057,176 | $41.43 | 5 |
| 2025 Q3 | 42,970,633 | $1,114,223,528 | +$108,250,251 | $25.93 | 93 |
| 2025 Q2 | 38,836,437 | $476,719,891 | -$14,337,291 | $12.27 | 74 |
| 2025 Q1 | 40,038,674 | $441,393,116 | +$441,263,463 | $11.01 | 68 |