| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Catalys Pacific Fund, LP | 14% | $136,659,680 | 8,978,954 | Catalys Pacific Fund, LP | 30 Jun 2025 | |||
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | 0% | $118,661,710 | +$22,964,484 | 7,796,433 | +24% | RA Capital Management, L.P. | 04 Sep 2025 |
| Samsara BioCapital, L.P. | 8.2% | -10% | $96,589,073 | +$9,282,511 | 6,346,194 | +11% | Srinivas Akkaraju | 04 Sep 2025 |
| Andera Partners | 4.2% | $42,098,155 | 2,765,976 | Andera Partners | 30 Jun 2025 | |||
| ADAMS STREET PARTNERS LLC | 2.3% | $14,495,424 | 1,129,807 | Adams Street Partners, LLC | 31 Dec 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Catalys Pacific, LLC | 12% | 8,903,838 | 0% | 96% | $337,633,537 |
| RA CAPITAL MANAGEMENT, L.P. | 9.5% | 7,323,750 | +19% | 3.4% | $277,716,600 |
| SAMSARA BIOCAPITAL, LLC | 8.1% | 6,263,151 | +10% | 31% | $237,498,686 |
| BlackRock, Inc. | 4.7% | 3,671,614 | +19% | 0% | $139,227,602 |
| VANGUARD GROUP INC | 3.9% | 3,018,999 | +30% | 0% | $114,480,442 |
| Caligan Partners LP | 3.6% | 2,772,654 | +37% | 15% | $105,139,040 |
| Capital International Investors | 3.1% | 2,393,396 | -17% | 0.01% | $90,757,576 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2.8% | 2,132,133 | +22% | 2.5% | $80,850,483 |
| SR One Capital Management, LP | 2.7% | 2,113,933 | -32% | 12% | $80,160,339 |
| FMR LLC | 2.7% | 2,071,255 | +579% | 0% | $78,541,989 |
| CITADEL ADVISORS LLC | 2.7% | 2,067,227 | +14274% | 0.06% | $78,389,248 |
| FRANKLIN RESOURCES INC | 2.3% | 1,809,768 | +0.34% | 0.02% | $68,626,402 |
| Point72 Asset Management, L.P. | 2.3% | 1,799,628 | 0.15% | $68,241,889 | |
| Laurion Capital Management LP | 2.2% | 1,720,445 | -2.4% | 8.9% | $65,239,274 |
| FARALLON CAPITAL MANAGEMENT LLC | 2.2% | 1,673,053 | 0.36% | $63,442,170 | |
| Integral Health Asset Management, LLC | 1.9% | 1,500,000 | -44% | 4.1% | $56,880,000 |
| ORBIMED ADVISORS LLC | 1.9% | 1,469,494 | +93% | 1.3% | $55,723,212 |
| MORGAN STANLEY | 1.8% | 1,376,997 | +134% | 0% | $52,215,755 |
| STATE STREET CORP | 1.7% | 1,303,023 | -9.7% | 0% | $49,410,632 |
| Holocene Advisors, LP | 1.6% | 1,205,377 | 0.11% | $45,707,896 | |
| GEODE CAPITAL MANAGEMENT, LLC | 1.5% | 1,123,411 | +18% | 0% | $42,608,185 |
| Polar Capital Holdings Plc | 1.4% | 1,058,776 | 0.19% | $40,148,786 | |
| BOOTHBAY FUND MANAGEMENT, LLC | 1.2% | 942,626 | +15% | 0.9% | $35,744,378 |
| Pictet Asset Management Holding SA | 1.2% | 929,169 | -27% | 0.03% | $35,234,088 |
| ALLIANCEBERNSTEIN L.P. | 1.1% | 882,415 | +3160% | 0.01% | $33,461,177 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 232,154 | $8,425,320 | +$4,746,000 | 3,629.15% | 5 |
| 2025 Q3 | 79,306,949 | $3,007,317,130 | +$505,416,558 | 3,792% | 191 |
| 2025 Q2 | 65,687,280 | $888,767,559 | +$52,640,118 | 1,353% | 164 |
| 2025 Q1 | 61,178,854 | $971,385,321 | +$245,430,094 | 1,588% | 148 |
| 2024 Q4 | 46,486,259 | $572,248,967 | +$24,847,746 | 1,231% | 108 |
| 2024 Q3 | 44,382,325 | $540,052,163 | +$2,379,004 | 1,211% | 105 |
| 2024 Q2 | 44,151,028 | $516,569,184 | +$24,151,309 | 1,170% | 93 |
| 2024 Q1 | 41,871,642 | $540,562,555 | +$94,145,212 | 1,291% | 91 |
| 2023 Q4 | 20,500 | $176,300 | -$104,920 | 860% | 1 |
| 2023 Q3 | 26,512,068 | $252,135,312 | -$9,252,095 | 951% | 77 |
| 2023 Q2 | 25,186,898 | $429,225,054 | +$10,759,776 | 1,705% | 68 |
| 2023 Q1 | 24,614,198 | $385,430,964 | +$385,430,964 | 1,566% | 66 |