| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 20% | +1.6% | $105,096,089 | +$9,388,186 | 1,287,368 | +9.8% | JANUS HENDERSON GROUP PLC | 30 Sep 2025 |
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | 0% | $60,644,498 | +$10,020,460 | 742,861 | +20% | RA Capital Management, L.P. | 30 Sep 2025 |
| Monopar Therapeutics | 13% | $24,591,484 | 704,829 | Hendricks Diane | 09 Dec 2024 | |||
| Adage Capital Management, L.P. | 9.9% | $20,905,914 | 599,195 | Adage Capital Management, L.P. | 31 Dec 2024 | |||
| Tactic Pharma LLC | 7.5% | $18,253,536 | 506,199 | Robinson Chandler | 24 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 17% | 1,287,368 | +9.8% | 0.05% | $105,313,139 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 8.8% | 659,195 | +10% | 0.09% | $53,836,456 |
| RA CAPITAL MANAGEMENT, L.P. | 6.8% | 511,207 | 0% | 0.51% | $41,750,276 |
| WELLINGTON MANAGEMENT GROUP LLP | 3.1% | 231,463 | 0% | $18,903,584 | |
| VANGUARD GROUP INC | 2.8% | 208,218 | +141% | 0% | $17,005,165 |
| BlackRock, Inc. | 2.7% | 203,751 | -0.69% | 0% | $16,640,345 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2.1% | 159,765 | 0.2% | $13,048,008 | |
| Saturn V Capital Management LP | 2.1% | 155,370 | 2.8% | $12,689,068 | |
| TCG Crossover Management, LLC | 2% | 153,000 | 0.61% | $12,495,510 | |
| ADAR1 Capital Management, LLC | 1.7% | 129,999 | +29% | 1.1% | $10,617,018 |
| Vivo Capital, LLC | 1.2% | 90,500 | 0.59% | $7,391,135 | |
| GEODE CAPITAL MANAGEMENT, LLC | 1.1% | 84,961 | -12% | 0% | $6,940,459 |
| Affinity Asset Advisors, LLC | 1.1% | 79,483 | +18% | 0.6% | $6,491,377 |
| STATE STREET CORP | 0.96% | 72,238 | +73% | 0% | $5,899,677 |
| Driehaus Capital Management LLC | 0.86% | 64,636 | 0.04% | $5,278,822 | |
| Ally Bridge Group (NY) LLC | 0.86% | 64,455 | +87% | 4.4% | $5,264,040 |
| NORTHERN TRUST CORP | 0.36% | 26,855 | -16% | 0% | $2,193,247 |
| Bank of New York Mellon Corp | 0.23% | 17,170 | +92% | 0% | $1,402,260 |
| MORGAN STANLEY | 0.21% | 15,711 | +98% | 0% | $1,283,118 |
| BARCLAYS PLC | 0.2% | 15,082 | +107% | 0% | $1,231,747 |
| Informed Momentum Co LLC | 0.19% | 14,629 | 0.14% | $1,194,750 | |
| Alyeska Investment Group, L.P. | 0.16% | 12,215 | 0% | $997,599 | |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.16% | 11,797 | -11% | 0% | $963,461 |
| UBS Group AG | 0.11% | 7,973 | -64% | 0% | $651,154 |
| MILLENNIUM MANAGEMENT LLC | 0.1% | 7,334 | -50% | 0% | $598,968 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 14 | $914 | +$196 | $65.29 | 1 |
| 2025 Q3 | 4,336,026 | $354,298,233 | +$99,764,615 | $81.67 | 55 |
| 2025 Q2 | 3,176,497 | $113,304,454 | +$10,313,027 | $35.78 | 43 |
| 2025 Q1 | 2,886,019 | $109,374,138 | +$11,536,778 | $36.41 | 34 |
| 2024 Q4 | 2,578,295 | $57,125,546 | +$56,777,792 | $22.00 | 18 |
| 2024 Q3 | 15,707 | $105,865 | +$105,864 | $6.74 | 6 |