| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 10% | $16,487,119 | 1,498,829 | RTW Investments, LP | 31 Dec 2024 | |||
| Redmile Group, LLC | 9.9% | $16,277,426 | 1,479,766 | Redmile Group, LLC | 31 Dec 2024 | |||
| EcoR1 Capital, LLC | 9.9% | $25,005,492 | 1,442,902 | EcoR1 Capital, LLC | 30 Sep 2025 | |||
| Casdin Capital, LLC | 8.7% | $14,248,971 | 1,295,361 | Casdin Capital, LLC | 31 Dec 2024 | |||
| BlackRock, Inc. | 6.8% | $11,125,796 | 1,011,436 | BlackRock, Inc. | 31 Mar 2025 | |||
| BAKER BROS. ADVISORS LP | 7% | -30% | $18,685,587 | -$9,316,550 | 991,804 | -33% | Julian C. Baker | 30 Jun 2025 |
| Trails Edge Capital Partners, LP | 5.1% | $16,477,150 | 785,000 | Trails Edge Capital Partners, LP | 08 Dec 2025 | |||
| FMR LLC | 3.1% | $5,091,669 | 462,879 | FMR LLC | 31 Mar 2025 | |||
| GREAT POINT PARTNERS LLC | 3% | $4,870,371 | 442,761 | Great Point Partners, LLC | 31 Dec 2024 | |||
| Commodore Capital LP | 3% | $8,060,995 | 427,866 | Commodore Capital LP | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| SAMSARA BIOCAPITAL, LLC | 11% | 1,717,127 | 0% | 3.9% | $29,757,811 |
| RTW INVESTMENTS, LP | 8.9% | 1,362,456 | 0% | 0.29% | $23,611,362 |
| Redmile Group, LLC | 8.4% | 1,299,022 | +1.8% | 2.2% | $22,512,051 |
| Casdin Capital, LLC | 8.4% | 1,295,361 | 0% | 1.9% | $22,448,606 |
| EcoR1 Capital, LLC | 8.3% | 1,271,342 | 0% | 1.1% | $22,032,357 |
| BAKER BROS. ADVISORS LP | 6.4% | 991,691 | 0% | 0.12% | $17,186,005 |
| BlackRock, Inc. | 6.2% | 951,100 | -2.7% | 0% | $16,482,563 |
| Balyasny Asset Management L.P. | 4.5% | 699,002 | 0.02% | $12,113,708 | |
| TORONTO DOMINION BANK | 4.4% | 681,337 | 0% | 0.02% | $11,807,570 |
| VANGUARD GROUP INC | 3.9% | 604,611 | -0.94% | 0% | $10,477,909 |
| ArrowMark Colorado Holdings LLC | 3.9% | 595,839 | +1.8% | 0.19% | $10,325,890 |
| GREAT POINT PARTNERS LLC | 2.9% | 446,814 | -8% | 3.2% | $7,743,287 |
| MORGAN STANLEY | 2.8% | 426,576 | -22% | 0% | $7,392,562 |
| JENNISON ASSOCIATES LLC | 2.6% | 394,089 | +135% | 0% | $6,829,562 |
| Octagon Capital Advisors LP | 1.6% | 252,000 | -17% | 0.68% | $4,367,160 |
| MILLENNIUM MANAGEMENT LLC | 1.6% | 247,864 | -19% | 0% | $4,295,483 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.6% | 246,433 | -0.54% | 0% | $4,271,457 |
| UBS Group AG | 1.5% | 227,716 | -5.2% | 0% | $3,946,319 |
| STATE STREET CORP | 1.4% | 208,310 | -1.2% | 0% | $3,610,012 |
| DEUTSCHE BANK AG\ | 0.99% | 152,284 | +0.77% | 0% | $2,639,082 |
| BLAIR WILLIAM & CO/IL | 0.92% | 141,820 | +6.4% | 0.01% | $2,457,741 |
| FMR LLC | 0.75% | 115,550 | -75% | 0% | $2,002,482 |
| Rock Springs Capital Management LP | 0.68% | 104,339 | 0% | 0.11% | $1,808,195 |
| NORTHERN TRUST CORP | 0.59% | 90,098 | -3.3% | 0% | $1,561,399 |
| Woodline Partners LP | 0.54% | 83,835 | 0% | 0.01% | $1,452,861 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 441 | $9,085 | -$2,245 | $20.60 | 2 |
| 2025 Q3 | 15,298,947 | $265,156,048 | -$165,307 | $17.33 | 87 |
| 2025 Q2 | 15,388,370 | $230,113,281 | -$13,642,152 | $14.95 | 81 |
| 2025 Q1 | 16,456,922 | $192,795,827 | +$733,704 | $11.71 | 83 |
| 2024 Q4 | 16,089,357 | $367,798,844 | +$14,465,355 | $22.86 | 86 |
| 2024 Q3 | 13,847,659 | $581,113,699 | +$18,023,447 | $41.96 | 85 |
| 2024 Q2 | 13,265,527 | $482,740,885 | +$37,444,033 | $36.39 | 66 |
| 2024 Q1 | 12,128,797 | $617,303,585 | +$143,858,541 | $50.90 | 58 |
| 2023 Q4 | 9,233,865 | $178,953,482 | +$172,259,940 | $19.38 | 35 |