| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 9.9% | $10,941,996 | 7,014,100 | TANG CAPITAL MANAGEMENT, LLC | 17 Jan 2025 | |||
| BlackRock, Inc. | 5% | $7,292,880 | 3,524,322 | BlackRock, Inc. | 30 Sep 2025 | |||
| Samsara BioCapital, L.P. | 4.9% | $8,383,322 | 3,507,666 | Samsara BioCapital, L.P. | 20 Nov 2025 | |||
| CITADEL ADVISORS LLC | 4.1% | $6,003,741 | 2,900,358 | Kenneth Griffin | 30 Sep 2025 | |||
| LSP 6 Holding C.V. | 4% | $4,425,001 | 2,836,539 | LSP 6 Management B.V. | 12 Feb 2025 | |||
| COMMODORE CAPITAL LP | 0.5% | $548,883 | 351,848 | COMMODORE CAPITAL LP | 31 Dec 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 15% | 10,805,129 | 0% | 0.28% | $22,366,617 |
| TANG CAPITAL MANAGEMENT LLC | 9.9% | 7,055,576 | 0% | 0.56% | $14,605,042 |
| SAMSARA BIOCAPITAL, LLC | 5.3% | 3,768,035 | 0% | 1% | $7,799,832 |
| BlackRock, Inc. | 5.2% | 3,698,537 | -11% | 0% | $7,655,971 |
| NEA Management Company, LLC | 5% | 3,568,781 | 0% | 0.41% | $7,387,377 |
| SR One Capital Management, LP | 4.7% | 3,333,333 | 0% | 1% | $6,899,999 |
| CITADEL ADVISORS LLC | 4.1% | 2,899,758 | -12% | 0% | $6,002,499 |
| VANGUARD GROUP INC | 3.5% | 2,491,717 | -2.4% | 0% | $5,157,855 |
| Alyeska Investment Group, L.P. | 2.9% | 2,084,696 | 0% | 0.01% | $4,315,321 |
| Monaco Asset Management SAM | 2.8% | 1,970,910 | +24% | 1.5% | $4,079,784 |
| WASATCH ADVISORS LP | 2.3% | 1,637,737 | -8.3% | 0.02% | $3,390,116 |
| STATE STREET CORP | 1.6% | 1,148,115 | +0.89% | 0% | $2,376,598 |
| RENAISSANCE TECHNOLOGIES LLC | 1.6% | 1,145,077 | +64% | 0% | $2,370,309 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.5% | 1,068,105 | -12% | 0% | $2,211,496 |
| AWM Investment Company, Inc. | 1.1% | 800,000 | +14% | 0.16% | $1,656,000 |
| MILLENNIUM MANAGEMENT LLC | 1% | 748,494 | 0% | $1,549,383 | |
| Blackstone Inc. | 1% | 747,044 | 0% | 0.01% | $1,546,381 |
| Peapod Lane Capital LLC | 0.94% | 671,266 | +1.1% | 1.2% | $1,389,704 |
| JPMORGAN CHASE & CO | 0.78% | 558,840 | -3.3% | 0% | $1,156,798 |
| TWO SIGMA INVESTMENTS, LP | 0.73% | 520,172 | +91% | 0% | $1,076,756 |
| ACADIAN ASSET MANAGEMENT LLC | 0.71% | 510,696 | +7.3% | 0% | $1,054,000 |
| MORGAN STANLEY | 0.66% | 473,217 | +46% | 0% | $979,559 |
| BANK OF AMERICA CORP /DE/ | 0.62% | 442,493 | -40% | 0% | $915,960 |
| ROYAL BANK OF CANADA | 0.57% | 406,389 | +0.16% | 0% | $842,000 |
| AQR CAPITAL MANAGEMENT LLC | 0.55% | 392,565 | -13% | 0% | $812,609 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 192 | $355 | +$355 | $1.85 | 1 |
| 2025 Q3 | 57,706,282 | $119,448,874 | -$669,803 | $2.07 | 120 |
| 2025 Q2 | 58,386,753 | $96,921,989 | -$5,560,690 | $1.66 | 104 |
| 2025 Q1 | 61,535,730 | $113,228,607 | -$4,989,975 | $1.84 | 111 |
| 2024 Q4 | 62,166,078 | $154,771,548 | -$34,973,275 | $2.49 | 111 |
| 2024 Q3 | 66,758,587 | $301,729,675 | +$1,030,811 | $4.52 | 119 |
| 2024 Q2 | 66,214,207 | $391,326,388 | -$11,926,375 | $5.91 | 112 |
| 2024 Q1 | 63,548,965 | $686,971,837 | +$247,780,443 | $10.81 | 111 |
| 2023 Q4 | 7,200 | $44,784 | $6.22 | 1 | |
| 2023 Q3 | 36,461,047 | $50,680,756 | -$4,878,343 | $1.39 | 83 |
| 2023 Q2 | 39,505,029 | $86,518,168 | -$7,291,945 | $2.19 | 96 |
| 2023 Q1 | 41,393,320 | $146,917,136 | -$7,750,136 | $3.55 | 98 |
| 2022 Q4 | 42,044,978 | $251,840,952 | -$39,525,621 | $5.99 | 119 |
| 2022 Q3 | 42,492,436 | $559,067,642 | -$56,532,392 | $13.16 | 98 |
| 2022 Q2 | 43,558,918 | $536,646,443 | +$210,787,744 | $12.32 | 110 |
| 2022 Q1 | 25,211,196 | $286,910,559 | +$14,238,307 | $11.38 | 78 |
| 2021 Q4 | 23,590,733 | $361,999,373 | -$41,756,493 | $15.35 | 84 |
| 2021 Q3 | 23,400,270 | $650,969,015 | -$20,918,598 | $27.81 | 83 |
| 2021 Q2 | 24,125,793 | $764,520,273 | -$67,931,799 | $31.69 | 87 |
| 2021 Q1 | 26,224,878 | $862,636,510 | -$12,999,417 | $32.90 | 95 |
| 2020 Q4 | 25,071,887 | $1,541,122,917 | +$6,320,476 | $61.47 | 84 |
| 2020 Q3 | 25,259,445 | $759,507,213 | +$755,561,639 | $30.06 | 56 |
| 2020 Q2 | 124,520 | $3,946,000 | $0 | $31.69 | 1 |
| 2020 Q1 | 124,520 | $3,946,000 | $0 | $31.69 | 1 |
| 2019 Q4 | 124,520 | $3,946,000 | $0 | $31.69 | 1 |
| 2019 Q3 | 124,520 | $3,946,000 | $0 | $31.69 | 1 |
| 2019 Q2 | 124,520 | $3,946,000 | $0 | $31.69 | 1 |
| 2019 Q1 | 124,520 | $3,946,000 | $0 | $31.69 | 1 |