| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 15% | +22% | $371,574,057 | +$142,354,542 | 31,785,634 | +62% | FMR LLC | 30 Sep 2025 |
| Deep Track Capital, LP | 6.2% | -35% | $153,090,545 | -$27,615,088 | 13,095,855 | -15% | Deep Track Capital, LP | 30 Sep 2025 |
| Venrock Healthcare Capital Partners III, L.P. | 7.3% | $150,957,880 | 12,913,420 | Venrock Healthcare Capital Partners III, L.P. | 30 Sep 2025 | |||
| SUMMER ROAD LLC | 5.7% | $146,825,720 | 12,134,357 | SUMMER ROAD LLC | 04 Dec 2025 | |||
| BlackRock, Inc. | 5.8% | $118,890,012 | 10,170,232 | BlackRock, Inc. | 30 Sep 2025 | |||
| Opaleye Management Inc. | 2.8% | $30,397,500 | 4,342,500 | Opaleye Management Inc. | 31 Dec 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 15% | 31,785,634 | +62% | 0.02% | $371,574,056 |
| VR ADVISER, LLC | 6.2% | 13,161,462 | +3.1% | 8.7% | $153,857,491 |
| Summer Road LLC | 5.9% | 12,579,657 | -9.4% | 99% | $147,050,970 |
| Deep Track Capital, LP | 5.6% | 11,932,137 | -17% | 3.9% | $139,486,682 |
| BlackRock, Inc. | 5% | 10,556,837 | +0.1% | 0% | $123,409,426 |
| Avoro Capital Advisors LLC | 4.8% | 10,250,000 | +39% | 1.6% | $119,822,500 |
| VANGUARD GROUP INC | 4.3% | 9,163,240 | +9.2% | 0% | $107,118,275 |
| TCG Crossover Management, LLC | 2.9% | 6,117,232 | +15% | 3.5% | $71,510,442 |
| CITADEL ADVISORS LLC | 2.7% | 5,703,781 | +17% | 0.05% | $66,677,200 |
| Point72 Asset Management, L.P. | 2.2% | 4,601,321 | +142% | 0.12% | $53,789,442 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.9% | 4,004,350 | +2.9% | 0.07% | $46,810,852 |
| MILLENNIUM MANAGEMENT LLC | 1.8% | 3,855,706 | +3136% | 0.04% | $45,073,203 |
| Paradigm Biocapital Advisors LP | 1.6% | 3,497,307 | +2.3% | 1.2% | $40,883,519 |
| STATE STREET CORP | 1.6% | 3,460,012 | -1.4% | 0% | $40,447,540 |
| ALLIANCEBERNSTEIN L.P. | 1.6% | 3,424,439 | +2003% | 0.01% | $40,031,692 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.6% | 3,338,453 | +1.7% | 0% | $39,032,331 |
| Logos Global Management LP | 1.5% | 3,250,000 | +48% | 3.8% | $37,992,500 |
| DELTEC ASSET MANAGEMENT LLC | 1.3% | 2,762,459 | -1.2% | 5.3% | $32,293,146 |
| Octagon Capital Advisors LP | 1.2% | 2,624,000 | +8.2% | 4.8% | $30,674,560 |
| MORGAN STANLEY | 1.2% | 2,465,676 | -4.1% | 0% | $28,823,760 |
| Balyasny Asset Management L.P. | 1% | 2,189,276 | +903% | 0.05% | $25,592,636 |
| JANUS HENDERSON GROUP PLC | 0.96% | 2,048,500 | +3729% | 0.01% | $23,957,208 |
| Woodline Partners LP | 0.78% | 1,666,087 | +122% | 0.09% | $19,476,557 |
| MARSHALL WACE, LLP | 0.75% | 1,601,449 | 0.02% | $18,720,939 | |
| Opaleye Management Inc. | 0.75% | 1,595,000 | 0% | 2.6% | $18,645,550 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 24,159 | $238,501 | -$26,381 | $10.89 | 2 |
| 2025 Q3 | 188,183,067 | $2,200,136,926 | +$370,626,573 | $11.69 | 213 |
| 2025 Q2 | 156,434,424 | $1,451,692,801 | +$187,013,451 | $9.28 | 182 |
| 2025 Q1 | 137,366,906 | $1,007,015,553 | +$22,122,148 | $7.33 | 195 |
| 2024 Q4 | 133,836,585 | $1,142,920,717 | -$55,467,873 | $8.54 | 177 |
| 2024 Q3 | 139,959,663 | $1,219,694,031 | +$26,500,082 | $8.70 | 167 |
| 2024 Q2 | 137,354,354 | $939,474,494 | +$86,729,069 | $6.84 | 147 |
| 2024 Q1 | 123,356,169 | $1,120,774,666 | +$444,206,297 | $9.10 | 144 |
| 2023 Q4 | 285,650 | $1,288,147 | +$426,536 | $4.46 | 3 |
| 2023 Q3 | 40,270,330 | $126,445,664 | -$13,890,439 | $3.14 | 111 |
| 2023 Q2 | 43,179,624 | $222,772,538 | +$13,382,124 | $5.16 | 130 |
| 2023 Q1 | 40,134,860 | $211,507,415 | +$6,216,195 | $5.27 | 123 |
| 2022 Q4 | 39,438,591 | $110,821,725 | -$11,980,896 | $2.81 | 107 |
| 2022 Q3 | 42,658,981 | $177,026,106 | -$4,084,786 | $4.15 | 124 |
| 2022 Q2 | 44,187,454 | $177,740,871 | +$1,507,690 | $4.02 | 118 |
| 2022 Q1 | 43,340,872 | $214,625,610 | +$8,629,567 | $4.95 | 125 |
| 2021 Q4 | 35,827,526 | $249,421,636 | -$35,500,739 | $6.97 | 132 |
| 2021 Q3 | 44,352,232 | $443,841,670 | -$46,156,013 | $10.00 | 136 |
| 2021 Q2 | 48,209,398 | $683,549,827 | +$13,949,229 | $14.18 | 143 |
| 2021 Q1 | 47,139,902 | $773,715,370 | -$64,868,300 | $16.41 | 148 |
| 2020 Q4 | 50,237,231 | $1,039,869,327 | +$212,268,812 | $20.70 | 143 |
| 2020 Q3 | 39,773,072 | $302,720,116 | +$7,132,421 | $7.61 | 101 |
| 2020 Q2 | 38,676,765 | $322,007,676 | +$85,253,575 | $8.33 | 103 |
| 2020 Q1 | 28,477,673 | $140,961,353 | +$17,926,519 | $4.95 | 87 |
| 2019 Q4 | 22,369,194 | $88,356,589 | +$5,750,969 | $3.95 | 74 |
| 2019 Q3 | 23,087,551 | $70,190,921 | +$1,029,794 | $3.04 | 70 |
| 2019 Q2 | 19,366,898 | $85,218,931 | +$2,811,165 | $4.40 | 60 |
| 2019 Q1 | 19,465,269 | $77,277,906 | +$2,210,655 | $3.97 | 63 |
| 2018 Q4 | 18,664,429 | $74,278,322 | -$5,799,861 | $3.98 | 63 |
| 2018 Q3 | 21,626,747 | $148,790,295 | -$1,508,424 | $6.88 | 71 |
| 2018 Q2 | 21,841,690 | $147,387,866 | +$9,617,897 | $6.75 | 65 |
| 2018 Q1 | 20,397,061 | $132,786,813 | +$45,673,710 | $6.51 | 62 |
| 2017 Q4 | 12,037,446 | $53,583,388 | -$12,010,968 | $4.45 | 65 |
| 2017 Q3 | 15,580,222 | $96,502,272 | -$1,095,075 | $6.18 | 70 |
| 2017 Q2 | 15,253,112 | $141,393,882 | -$26,304,320 | $9.27 | 70 |
| 2017 Q1 | 18,346,444 | $170,228,516 | +$20,289,428 | $9.28 | 73 |
| 2016 Q4 | 17,394,280 | $145,604,494 | -$9,994,743 | $8.37 | 76 |
| 2016 Q3 | 18,785,162 | $129,054,713 | -$2,940,268 | $6.87 | 70 |
| 2016 Q2 | 19,414,509 | $96,096,641 | -$30,417,994 | $4.95 | 72 |
| 2016 Q1 | 20,860,674 | $201,445,609 | -$1,634,265 | $9.66 | 64 |
| 2015 Q4 | 20,957,093 | $196,368,107 | -$18,083,100 | $9.37 | 70 |
| 2015 Q3 | 20,040,411 | $281,763,540 | +$49,027,855 | $14.06 | 66 |
| 2015 Q2 | 16,071,389 | $337,378,009 | +$93,008,051 | $21.03 | 70 |
| 2015 Q1 | 10,685,598 | $448,622,275 | +$240,819,340 | $41.98 | 55 |
| 2014 Q4 | 5,006,746 | $117,752,025 | +$9,256,074 | $23.52 | 36 |
| 2014 Q3 | 4,629,882 | $69,305,000 | +$69,305,017 | $14.97 | 33 |