| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 10% | $23,625,349 | 7,429,355 | Paradigm BioCapital Advisors LP | 31 Dec 2024 | |||
| Bain Capital Life Sciences Opportunities IV, L.P. | 10% | 0% | $21,763,774 | -$800,807 | 6,843,954 | -3.5% | Bain Capital Life Sciences Opportunities IV, L.P. | 31 Mar 2025 |
| JANUS HENDERSON GROUP PLC | 5.2% | $35,105,462 | 3,585,849 | JANUS HENDERSON GROUP PLC | 30 Sep 2025 | |||
| Deep Track Capital, LP | 5% | $10,948,209 | 3,442,833 | Deep Track Capital, LP | 31 Mar 2025 | |||
| Logos Global Management LP | 4.7% | $10,204,222 | 3,208,875 | Logos Global Management LP | 18 Mar 2025 | |||
| Point72 Asset Management, L.P. | 2.3% | $4,909,701 | 1,543,931 | Point72 Asset Management, L.P. | 31 Mar 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Bain Capital Life Sciences Investors, LLC | 9.9% | 6,843,954 | 0% | 4.4% | $67,002,310 |
| Paradigm Biocapital Advisors LP | 9.9% | 6,794,172 | +0.44% | 2% | $66,514,944 |
| BVF INC/IL | 7.7% | 5,295,893 | 0% | 2.1% | $51,846,792 |
| BlackRock, Inc. | 6.9% | 4,726,394 | +2.6% | 0% | $46,271,397 |
| JANUS HENDERSON GROUP PLC | 5.2% | 3,585,849 | +19% | 0.02% | $35,087,532 |
| Deep Track Capital, LP | 5% | 3,470,172 | +0.79% | 0.95% | $33,972,984 |
| Logos Global Management LP | 4.7% | 3,208,875 | 0% | 3.1% | $31,414,886 |
| VANGUARD GROUP INC | 4.6% | 3,197,320 | -2.1% | 0% | $31,301,763 |
| FRANKLIN RESOURCES INC | 4.4% | 3,011,969 | 0% | 0.01% | $29,487,177 |
| Woodline Partners LP | 3.2% | 2,217,893 | -37% | 0.1% | $21,713,172 |
| LIGHTSPEED MANAGEMENT COMPANY, L.L.C. | 2.8% | 1,930,894 | 0% | 5.9% | $18,903,452 |
| Pictet Asset Management Holding SA | 2.4% | 1,636,372 | -13% | 0.02% | $16,020,082 |
| MORGAN STANLEY | 2.3% | 1,555,887 | +8.2% | 0% | $15,232,135 |
| Vivo Capital, LLC | 2.2% | 1,505,862 | 0% | 1.2% | $14,742,389 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.9% | 1,276,005 | -3.8% | 0% | $12,494,439 |
| Candriam S.C.A. | 1.8% | 1,249,727 | +47% | 0.06% | $12,234,827 |
| CITADEL ADVISORS LLC | 1.8% | 1,236,915 | -28% | 0.01% | $12,109,398 |
| UBS Group AG | 1.7% | 1,190,654 | -16% | 0% | $11,656,502 |
| AMERIPRISE FINANCIAL INC | 1.7% | 1,147,068 | -2.2% | 0% | $11,229,794 |
| STATE STREET CORP | 1.6% | 1,093,574 | +4% | 0% | $10,706,089 |
| DIMENSIONAL FUND ADVISORS LP | 1.5% | 1,064,549 | -12% | 0% | $10,420,648 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1.4% | 933,541 | 1.3% | $9,139,366 | |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 1.2% | 854,000 | 1.3% | $8,360,660 | |
| GOLDMAN SACHS GROUP INC | 1.2% | 803,881 | +11% | 0% | $7,869,995 |
| BANK OF AMERICA CORP /DE/ | 1.2% | 802,304 | +0.35% | 0% | $7,854,556 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 71,344 | $1,784,050 | +$1,741,176 | 2,500% | 4 |
| 2025 Q3 | 68,238,525 | $668,035,985 | -$3,229,141 | 979% | 123 |
| 2025 Q2 | 70,511,948 | $300,429,144 | +$22,565,292 | 426% | 120 |
| 2025 Q1 | 65,888,228 | $247,927,073 | -$30,654,940 | 376% | 131 |
| 2024 Q4 | 71,278,859 | $415,382,688 | +$48,509,849 | 583% | 154 |
| 2024 Q3 | 58,658,581 | $700,333,058 | +$12,522,075 | 1,194% | 129 |
| 2024 Q2 | 57,899,300 | $626,475,139 | +$18,110,213 | 1,082% | 127 |
| 2024 Q1 | 56,110,675 | $635,162,432 | +$37,694,017 | 1,132% | 126 |
| 2023 Q4 | 57,467 | $806,262 | +$282,340 | 1,403% | 3 |
| 2023 Q3 | 47,296,313 | $584,109,323 | +$135,064,057 | 1,235% | 96 |
| 2023 Q2 | 36,381,586 | $328,525,003 | +$43,216,031 | 903% | 85 |
| 2023 Q1 | 33,420,696 | $116,011,936 | +$1,787,486 | 347% | 64 |
| 2022 Q4 | 33,308,067 | $81,575,130 | -$798,711 | 245% | 65 |
| 2022 Q3 | 33,333,193 | $91,990,000 | -$3,940,631 | 275.98% | 66 |
| 2022 Q2 | 34,176,168 | $139,126,000 | -$8,594,155 | 407.01% | 68 |
| 2022 Q1 | 36,348,231 | $155,092,471 | -$17,933,682 | 425.99% | 84 |
| 2021 Q4 | 38,381,637 | $359,075,397 | -$41,573,356 | 935.97% | 91 |
| 2021 Q3 | 36,340,569 | $1,001,480,449 | -$19,825,144 | 2,755.99% | 73 |
| 2021 Q2 | 37,382,339 | $1,045,983,096 | +$59,045,057 | 2,798% | 67 |
| 2021 Q1 | 35,240,908 | $1,158,273,244 | -$1,711,119 | 3,318% | 72 |
| 2020 Q4 | 34,813,365 | $1,644,705,008 | +$1,644,681,092 | 4,807.98% | 55 |