OnKure Therapeutics, Inc. - Class A Common Stock, par value $0.0001 per share (OKUR) Institutional Ownership

13F Institutional Holders and Ownership History from Q3 2024 to Q3 2025

Type / Class
Equity / Class A Common Stock, par value $0.0001 per share
Symbol
OKUR on Nasdaq
Shares outstanding
12,856,017
Price per share
$3.23
All holders as of 30 Sep 2025
Q3 2025
Total 13F shares
10,219,608
Total reported value
$28,104,553
% of total 13F portfolios
0%
Share change
-559,478
Value change
-$1,295,979
Number of holders
42
Price from insider filings
$3.23
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of OnKure Therapeutics, Inc. - Class A Common Stock, par value $0.0001 per share (OKUR) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
ACORN BIOVENTURES, L.P. 22% $7,099,185 2,839,674 Anders Hove 15 May 2025
Shay Capital LLC 6.3% $2,057,944 810,214 Shay Capital LLC 15 May 2025
Prosight Management, LP 5.8% $2,214,578 745,649 Prosight Management, LP 24 Nov 2025
VANGUARD GROUP INC 5.6% $2,084,862 706,733 The Vanguard Group 31 Dec 2024
CANTOR FITZGERALD & CO. 5.2% $1,693,934 669,539 Cantor Fitzgerald Securities 30 Jun 2025
HIGHBRIDGE CAPITAL MANAGEMENT LLC 5.2% +67% $1,678,926 +$667,576 663,607 +66% Highbridge Capital Management, LLC 30 Jun 2025
Deep Track Capital, LP 4.1% $1,545,768 523,989 Deep Track Capital, LP 31 Dec 2024
Lundbeckfond Invest A/S 1.6% $599,210 203,122 Lundbeckfond Invest A/S 31 Dec 2024

As of 30 Sep 2025, 42 institutional investors reported holding 10,219,608 shares of OnKure Therapeutics, Inc. - Class A Common Stock, par value $0.0001 per share (OKUR). This represents 79% of the company’s total 12,856,017 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of OnKure Therapeutics, Inc. - Class A Common Stock, par value $0.0001 per share (OKUR) together control 79% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
ACORN CAPITAL ADVISORS, LLC 22% 2,839,674 0% 4% $7,809,104
CITADEL ADVISORS LLC 7.9% 1,016,613 -6.7% 0% $2,795,686
Shay Capital LLC 7.1% 917,934 +17% 0.46% $2,524,319
VANGUARD GROUP INC 5.3% 678,226 -4% 0% $1,865,122
HIGHBRIDGE CAPITAL MANAGEMENT LLC 5.1% 650,218 -2% 0.09% $1,788,100
Vestal Point Capital, LP 4.9% 635,000 0% 0.08% $1,746,250
BlackRock, Inc. 4.4% 564,836 +0.01% 0% $1,553,301
StepStone Group LP 3.8% 491,938 0% 0.67% $1,352,830
CANTOR FITZGERALD, L. P. 3.8% 491,863 -27% 0.03% $1,352,623
NEA Management Company, LLC 3.7% 478,548 0% 0.07% $1,316,007
Carlyle Group Inc. 2.1% 269,895 0% 0.02% $742,211
Prosight Management, LP 2.1% 267,959 +68% 0.18% $736,887
RENAISSANCE TECHNOLOGIES LLC 1.4% 175,750 +43% 0% $483,313
Rangeley Capital, LLC 1.2% 155,490 +420% 0.41% $427,598
TANG CAPITAL MANAGEMENT LLC 0.91% 116,395 -31% 0.01% $320,086
Aisling Capital Management LP 0.69% 88,607 0% 0.05% $243,669
GEODE CAPITAL MANAGEMENT, LLC 0.66% 84,895 0% 0% $233,475
SPHERA FUNDS MANAGEMENT LTD. 0.47% 60,454 0% 0.04% $166,249
GSA CAPITAL PARTNERS LLP 0.46% 59,224 +172% 0.01% $163,000
Aldebaran Capital, LLC 0.34% 43,997 -0.4% 0.11% $120,992
TWO SIGMA ADVISERS, LP 0.21% 26,608 -0.82% 0% $73,172
TWO SIGMA INVESTMENTS, LP 0.2% 25,435 -1.7% 0% $69,946
NORTHERN TRUST CORP 0.18% 22,510 0% 0% $61,903
BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.15% 19,500 -22% 0% $53,625
MORGAN STANLEY 0.13% 17,214 +3.1% 0% $47,338

Institutional Holders of OnKure Therapeutics, Inc. - Class A Common Stock, par value $0.0001 per share (OKUR) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q3 10,219,608 $28,104,553 -$1,295,979 $2.75 42
2025 Q2 10,778,865 $25,758,405 -$10,457,910 $2.39 48
2025 Q1 11,945,383 $50,147,392 -$1,567,884 $4.30 46
2024 Q4 11,839,301 $99,219,345 +$88,962,026 $8.60 49
2024 Q3 3,200 $5,440 +$5,440 $1.70 1