OPKO HEALTH, INC. - Common Stock, par value $0.01 per share (OPK) Institutional Ownership

13F Institutional Holders and Ownership History from Q1 2014 to Q4 2025

Type / Class
Equity / Common Stock, par value $0.01 per share
Symbol
OPK on Nasdaq
Shares outstanding
770,989,043
Price per share
$1.26
All holders as of 30 Sep 2025
Q3 2025
Total 13F shares
195,971,204
Total reported value
$303,592,859
% of total 13F portfolios
0%
Share change
-8,739,702
Value change
-$12,310,005
Number of holders
229
Price from insider filings
$1.26
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of OPKO HEALTH, INC. - Common Stock, par value $0.01 per share (OPK) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
FROST PHILLIP MD ET AL 33% +3.4% $351,509,324 +$674,150 252,884,406 +0.19% FROST PHILLIP MD ET AL 30 Sep 2025
Rubric Capital Management LP 6% $62,128,616 47,791,243 Rubric Capital Management LP 30 Jun 2025
HSIAO JANE PH D 4.5% $50,661,743 35,677,284 HSIAO JANE PH D 02 Apr 2025

As of 30 Sep 2025, 229 institutional investors reported holding 195,971,204 shares of OPKO HEALTH, INC. - Common Stock, par value $0.01 per share (OPK). This represents 25% of the company’s total 770,989,043 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of OPKO HEALTH, INC. - Common Stock, par value $0.01 per share (OPK) together control 23% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
Rubric Capital Management LP 6.2% 47,791,243 0% 0.99% $74,076,427
VANGUARD GROUP INC 4.9% 37,535,897 -1.8% 0% $58,180,641
BlackRock, Inc. 4.3% 33,172,384 +5.5% 0% $51,417,196
GEODE CAPITAL MANAGEMENT, LLC 1.4% 10,993,345 +5.5% 0% $17,043,109
STATE STREET CORP 1.2% 8,997,940 +4.8% 0% $13,946,807
Whitefort Capital Management, LP 0.64% 4,900,000 +176% 2.5% $7,595,000
UBS Group AG 0.62% 4,775,536 -17% 0% $7,402,080
CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.49% 3,768,934 +12% 0% $5,841,848
NORTHERN TRUST CORP 0.47% 3,657,846 +5% 0% $5,669,661
AQR CAPITAL MANAGEMENT LLC 0.37% 2,873,416 +207% 0% $4,453,795
GOLDMAN SACHS GROUP INC 0.31% 2,386,535 -15% 0% $3,699,129
AWM Investment Company, Inc. 0.29% 2,200,000 +10% 0.32% $3,410,000
DIMENSIONAL FUND ADVISORS LP 0.22% 1,667,368 -14% 0% $2,582,192
Y.D. More Investments Ltd 0.19% 1,499,118 -1.9% 0.13% $2,235,527
WASHINGTON GROWTH STRATEGIES LLC 0.18% 1,356,124 0% 1.5% $2,101,993
PFG Investments, LLC 0.17% 1,337,375 +5.7% 0.11% $2,072,931
BANK OF AMERICA CORP /DE/ 0.17% 1,313,882 -31% 0% $2,036,518
Bank of New York Mellon Corp 0.17% 1,276,868 +11% 0% $1,979,146
TWO SIGMA INVESTMENTS, LP 0.16% 1,255,647 -32% 0% $1,946,253
Voya Investment Management LLC 0.16% 1,218,002 -7.7% 0% $1,887,903
Weiss Asset Management LP 0.15% 1,130,771 -76% 0.03% $1,752,695
Invesco Ltd. 0.13% 1,017,561 -26% 0% $1,577,220
Tejara Capital Ltd 0.11% 877,941 -7.2% 0.75% $1,360,809
Swiss National Bank 0.11% 845,755 +46% 0% $1,310,920
Nuveen, LLC 0.11% 841,836 -25% 0% $1,304,846

Institutional Holders of OPKO HEALTH, INC. - Common Stock, par value $0.01 per share (OPK) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 862,126 $1,102,795 -$200,765 $1.26 11
2025 Q3 195,971,204 $303,592,859 -$12,310,005 $1.55 229
2025 Q2 205,374,726 $270,660,296 -$60,618,151 $1.32 216
2025 Q1 241,258,198 $400,533,493 +$72,053,375 $1.66 247
2024 Q4 196,889,128 $289,470,342 +$16,835,310 $1.47 228
2024 Q3 185,344,346 $276,181,036 +$6,393,604 $1.49 230
2024 Q2 182,145,781 $227,699,858 +$34,955,517 $1.25 230
2024 Q1 156,091,695 $187,317,399 -$17,815,465 $1.20 221
2023 Q4 1,874,801 $2,830,950 -$93,765 $1.51 3
2023 Q3 162,366,844 $259,733,037 -$11,230,646 $1.60 214
2023 Q2 169,640,220 $367,516,139 -$12,138,476 $2.17 220
2023 Q1 174,378,384 $254,425,150 -$2,903,952 $1.46 210
2022 Q4 179,367,075 $224,145,980 -$10,299,459 $1.25 210
2022 Q3 184,738,816 $349,117,222 -$11,643,278 $1.89 197
2022 Q2 186,857,713 $472,693,698 -$7,757,300 $2.53 206
2022 Q1 194,157,609 $668,507,976 +$25,077,660 $3.44 212
2021 Q4 187,131,662 $900,306,593 +$31,551,352 $4.81 219
2021 Q3 181,895,309 $663,969,243 -$30,819,490 $3.65 196
2021 Q2 190,948,442 $773,257,727 +$323,865 $4.05 224
2021 Q1 190,433,466 $816,851,585 +$7,008,275 $4.29 229
2020 Q4 186,695,822 $737,581,355 -$25,381,096 $3.95 223
2020 Q3 195,035,275 $719,384,530 -$11,723,901 $3.69 201
2020 Q2 198,219,394 $675,652,129 +$104,587,698 $3.41 193
2020 Q1 161,193,062 $215,972,986 -$18,790,785 $1.34 160
2019 Q4 170,407,739 $250,511,436 +$39,581,284 $1.47 179
2019 Q3 147,148,201 $307,563,502 -$21,618,349 $2.09 171
2019 Q2 150,306,667 $366,277,993 +$3,238,700 $2.44 182
2019 Q1 155,159,409 $404,185,183 +$42,926,700 $2.61 179
2018 Q4 137,730,151 $414,247,109 -$31,905,595 $3.01 181
2018 Q3 152,157,464 $526,424,914 +$32,091,946 $3.46 194
2018 Q2 140,874,317 $662,127,176 +$44,449,504 $4.70 198
2018 Q1 132,365,639 $419,563,667 +$20,941,690 $3.17 206
2017 Q4 129,078,348 $632,474,010 -$11,931,375 $4.90 211
2017 Q3 131,334,743 $900,766,354 +$17,483,593 $6.86 225
2017 Q2 127,406,285 $838,421,098 -$15,045,909 $6.58 219
2017 Q1 130,547,005 $1,044,425,850 +$155,444,231 $8.00 229
2016 Q4 130,798,729 $1,217,115,685 +$42,018,021 $9.30 237
2016 Q3 126,181,492 $1,334,706,777 +$119,219,236 $10.59 257
2016 Q2 115,247,276 $1,076,478,990 +$47,535,611 $9.34 233
2016 Q1 109,103,682 $1,133,144,775 -$52,446,560 $10.39 247
2015 Q4 115,476,389 $1,160,493,963 -$134,848,257 $10.05 262
2015 Q3 123,014,696 $1,033,816,480 +$276,214,108 $8.41 254
2015 Q2 83,229,083 $1,338,148,135 +$81,487,271 $16.08 213
2015 Q1 80,721,201 $1,142,242,411 +$38,121,295 $14.17 189
2014 Q4 77,265,205 $771,955,900 +$27,794,744 $9.99 174
2014 Q3 74,688,995 $635,471,500 -$64,068,770 $8.51 179
2014 Q2 81,806,864 $723,162,643 +$87,038,431 $8.84 171
2014 Q1 72,774,020 $678,260,259 +$10,111,873 $9.32 165