| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Fairmount Funds Management LLC | 20% | 0% | $161,971,372 | +$38,464,806 | 11,162,741 | +31% | Fairmount Funds Management LLC | 17 Sep 2025 |
| Venrock Healthcare Capital Partners III, L.P. | 9.9% | -11% | $94,415,901 | +$14,638,312 | 4,909,619 | +18% | Venrock Healthcare Capital Partners III, L.P. | 30 Sep 2025 |
| VIKING GLOBAL INVESTORS LP | 5.5% | $38,693,672 | 2,666,690 | VIKING GLOBAL INVESTORS LP | 17 Sep 2025 | |||
| BlackRock, Inc. | 4.5% | -16% | $43,430,407 | +$4,123,376 | 2,197,517 | +10% | BlackRock, Inc. | 30 Sep 2025 |
| RTW INVESTMENTS, LP | 5.2% | $18,328,014 | 1,945,649 | RTW Investments, LP | 31 Mar 2025 | |||
| Deep Track Capital, LP | 5.1% | $17,867,668 | 1,896,780 | Deep Track Capital, LP | 06 May 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 15% | 7,257,621 | +29% | 0.01% | $139,564,052 |
| VR ADVISER, LLC | 8.4% | 4,148,428 | 0% | 4.5% | $79,774,270 |
| Fairmount Funds Management LLC | 7.5% | 3,705,262 | +9.9% | 6.4% | $71,252,188 |
| VIKING GLOBAL INVESTORS LP | 5.4% | 2,666,690 | 0.13% | $51,280,449 | |
| Deep Track Capital, LP | 5.4% | 2,654,781 | +38% | 1.4% | $51,051,438 |
| BlackRock, Inc. | 4.4% | 2,204,551 | +11% | 0% | $42,393,516 |
| RTW INVESTMENTS, LP | 3.9% | 1,945,649 | 0% | 0.46% | $37,414,830 |
| VANGUARD GROUP INC | 3.6% | 1,776,665 | -2.2% | 0% | $34,165,268 |
| Commodore Capital LP | 3.5% | 1,753,054 | +23% | 1.6% | $33,711,228 |
| BRAIDWELL LP | 2.8% | 1,382,350 | -9.3% | 0.79% | $26,582,591 |
| Avoro Capital Advisors LLC | 2.7% | 1,333,340 | 0.33% | $25,640,128 | |
| PERCEPTIVE ADVISORS LLC | 2.6% | 1,268,021 | 0.71% | $24,384,044 | |
| FRANKLIN RESOURCES INC | 2.1% | 1,065,782 | +5.2% | 0.01% | $20,494,988 |
| Point72 Asset Management, L.P. | 2.1% | 1,037,002 | +214% | 0.04% | $19,941,548 |
| Polar Capital Holdings Plc | 2.1% | 1,032,307 | +5.9% | 0.1% | $19,851,264 |
| Affinity Asset Advisors, LLC | 1.9% | 959,180 | +59% | 1.7% | $18,445,031 |
| MERCER GLOBAL ADVISORS INC /ADV | 1.7% | 852,411 | +0.01% | 0.03% | $16,391,864 |
| Blackstone Inc. | 1.7% | 850,400 | +2.9% | 0.07% | $16,353,192 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.4% | 689,972 | -2.5% | 0% | $13,271,325 |
| Avidity Partners Management LP | 1.3% | 660,424 | +88% | 2.9% | $12,699,954 |
| STATE STREET CORP | 1.3% | 652,028 | +75% | 0% | $12,538,498 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.3% | 626,806 | +53% | 0% | $12,054,000 |
| Woodline Partners LP | 1.2% | 574,330 | +47% | 0.05% | $11,044,366 |
| Cormorant Asset Management, LP | 1.1% | 533,340 | 0.71% | $10,256,128 | |
| Cable Car Capital, LP | 1% | 500,000 | -17% | 4.1% | $9,615,000 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 8,402 | $254,850 | +$254,061 | $30.33 | 3 |
| 2025 Q3 | 45,557,409 | $875,822,951 | +$220,884,500 | $19.23 | 103 |
| 2025 Q2 | 34,429,035 | $385,950,468 | +$30,431,124 | $11.21 | 81 |
| 2025 Q1 | 31,776,517 | $326,087,518 | -$21,453,525 | $10.26 | 70 |
| 2024 Q4 | 31,038,311 | $606,624,310 | +$125,781,786 | $19.39 | 66 |
| 2024 Q3 | 24,559,501 | $604,174,991 | +$603,646,395 | $24.51 | 42 |