| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9.9% | $17,635,448 | 13,259,735 | RA Capital Management, L.P. | 11 Dec 2025 | |||
| Affinity Asset Advisors, LLC | 9% | $16,158,391 | 12,149,166 | Affinity Asset Advisors, LLC | 11 Dec 2025 | |||
| TAKEDA PHARMACEUTICAL CO LTD | 12% | $13,172,994 | 8,781,996 | Takeda Pharmaceutical Company Limited | 08 Dec 2025 | |||
| FEDERATED HERMES, INC. | 5.9% | $12,611,581 | 7,737,166 | Federated Hermes, Inc. | 31 Dec 2025 | |||
| JANUS HENDERSON GROUP PLC | 10% | $10,671,171 | 7,114,114 | JANUS HENDERSON GROUP PLC | 28 Nov 2025 | |||
| Point72 Asset Management, L.P. | 5.1% | $11,099,895 | 6,727,209 | Point72 Asset Management, L.P. | 02 Jan 2026 | |||
| Madison Avenue Partners, LP | 4% | $889,649 | 2,852,352 | Madison Avenue Partners, LP | 31 Dec 2024 | |||
| BlackRock, Inc. | 1.9% | $397,013 | 1,369,010 | BlackRock, Inc. | 30 Jun 2025 | |||
| Rubric Capital Management LP | 0.67% | $138,775 | 478,533 | Rubric Capital Management LP | 30 Jun 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| TAKEDA PHARMACEUTICAL CO LTD | 5.8% | 7,531,996 | 0% | 60% | $9,791,595 |
| VANGUARD GROUP INC | 2.2% | 2,820,813 | +7% | 0% | $3,667,058 |
| Affinity Asset Advisors, LLC | 2% | 2,650,000 | +297% | 0.32% | $3,445,000 |
| ACADIAN ASSET MANAGEMENT LLC | 1.8% | 2,286,505 | +8.5% | 0.01% | $2,971,000 |
| RENAISSANCE TECHNOLOGIES LLC | 1.5% | 2,018,024 | -3.7% | 0% | $2,623,431 |
| Sio Capital Management, LLC | 1.1% | 1,427,495 | -36% | 0.47% | $1,855,744 |
| Driehaus Capital Management LLC | 1.1% | 1,400,191 | 0% | 0.01% | $1,820,248 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1% | 1,350,000 | +17% | 0% | $1,755,000 |
| KENNEDY CAPITAL MANAGEMENT LLC | 0.85% | 1,106,638 | -26% | 0.03% | $1,438,629 |
| Ikarian Capital, LLC | 0.84% | 1,095,574 | 0.32% | $1,424,247 | |
| MILLENNIUM MANAGEMENT LLC | 0.76% | 986,293 | -6.3% | 0% | $1,282,181 |
| Assenagon Asset Management S.A. | 0.71% | 924,576 | +112% | 0% | $1,201,949 |
| Schonfeld Strategic Advisors LLC | 0.68% | 883,154 | 0.01% | $1,148,098 | |
| MARSHALL WACE, LLP | 0.6% | 783,653 | +376% | 0% | $1,018,751 |
| WELLS FARGO & COMPANY/MN | 0.56% | 730,716 | -4.2% | 0% | $949,932 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.5% | 648,020 | +0.73% | 0% | $842,631 |
| Balyasny Asset Management L.P. | 0.48% | 625,000 | 0% | $812,500 | |
| BlackRock, Inc. | 0.47% | 611,315 | -55% | 0% | $794,710 |
| Walleye Capital LLC | 0.46% | 596,717 | 0.01% | $775,732 | |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.45% | 589,094 | +156% | 0% | $765,822 |
| BOOTHBAY FUND MANAGEMENT, LLC | 0.37% | 486,877 | 0.02% | $632,940 | |
| CITADEL ADVISORS LLC | 0.31% | 405,382 | 0% | $526,997 | |
| SIMPLEX TRADING, LLC | 0.3% | 387,512 | 0.01% | $503,000 | |
| BANK OF AMERICA CORP /DE/ | 0.28% | 362,707 | +2333% | 0% | $471,519 |
| TWO SIGMA INVESTMENTS, LP | 0.26% | 341,134 | 0% | $443,474 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 628,019 | $1,023,671 | -$499,688 | $1.63 | 2 |
| 2025 Q3 | 36,211,271 | $47,075,130 | +$6,613,805 | $1.30 | 80 |
| 2025 Q2 | 35,963,686 | $11,861,338 | -$3,392,036 | $0.3299 | 69 |
| 2025 Q1 | 46,399,305 | $14,470,049 | -$2,823,887 | $0.3119 | 81 |
| 2024 Q4 | 47,565,663 | $44,391,458 | +$933,721 | $0.9337 | 80 |
| 2024 Q3 | 46,326,650 | $54,660,766 | -$2,312,504 | $1.18 | 76 |
| 2024 Q2 | 38,490,729 | $29,602,958 | -$20,868,723 | $0.7692 | 72 |
| 2024 Q1 | 50,111,416 | $152,838,666 | -$4,521,523 | $3.05 | 80 |
| 2023 Q4 | 7,558,793 | $24,339,313 | -$57,584 | $3.22 | 2 |
| 2023 Q3 | 42,343,665 | $162,597,735 | +$5,682,269 | $3.84 | 64 |
| 2023 Q2 | 41,007,449 | $134,502,709 | +$8,714,594 | $3.28 | 69 |
| 2023 Q1 | 38,694,424 | $99,783,463 | +$650,217 | $2.58 | 60 |
| 2022 Q4 | 38,555,681 | $71,711,529 | +$2,583,303 | $1.86 | 56 |
| 2022 Q3 | 33,884,019 | $62,344,293 | +$1,735,945 | $1.84 | 50 |
| 2022 Q2 | 34,197,216 | $73,522,307 | -$3,001,295 | $2.15 | 51 |
| 2022 Q1 | 35,129,902 | $110,306,198 | +$3,431,136 | $3.14 | 60 |
| 2021 Q4 | 33,993,138 | $109,111,202 | +$1,312,258 | $3.21 | 63 |
| 2021 Q3 | 33,589,655 | $112,863,212 | +$498,942 | $3.36 | 70 |
| 2021 Q2 | 33,196,688 | $129,797,427 | -$11,484,092 | $3.91 | 77 |
| 2021 Q1 | 32,755,130 | $131,671,613 | +$41,031,412 | $4.02 | 84 |
| 2020 Q4 | 24,830,644 | $57,358,129 | -$5,602,917 | $2.31 | 73 |
| 2020 Q3 | 25,114,493 | $144,162,828 | +$11,161,450 | $5.74 | 90 |
| 2020 Q2 | 19,727,290 | $145,398,711 | +$45,823,549 | $7.37 | 76 |
| 2020 Q1 | 13,602,580 | $40,539,209 | -$7,096,587 | $2.98 | 52 |
| 2019 Q4 | 17,742,744 | $73,634,290 | +$38,177,804 | $4.15 | 57 |
| 2019 Q3 | 8,206,512 | $26,588,025 | -$5,117,370 | $3.24 | 37 |
| 2019 Q2 | 10,118,552 | $18,720,869 | -$3,455,299 | $1.85 | 32 |
| 2019 Q1 | 12,276,057 | $21,733,954 | +$9,093,019 | $1.77 | 46 |
| 2018 Q4 | 6,835,729 | $16,540,605 | -$8,551,955 | $2.42 | 46 |
| 2018 Q3 | 7,392,582 | $41,915,393 | -$3,041,259 | $5.67 | 47 |
| 2018 Q2 | 7,651,267 | $59,676,116 | -$351,480 | $7.80 | 45 |
| 2018 Q1 | 7,048,747 | $49,828,303 | -$9,280,074 | $7.07 | 48 |
| 2017 Q4 | 7,821,975 | $77,207,294 | +$5,974,372 | $9.87 | 48 |
| 2017 Q3 | 7,221,932 | $61,486,225 | -$6,770,504 | $8.57 | 42 |
| 2017 Q2 | 7,962,804 | $81,479,560 | +$81,479,413 | $10.49 | 42 |