| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 9.4% | $6,965,407 | 4,975,291 | ORBIMED ADVISORS LLC | 23 Oct 2025 | |||
| TANG CAPITAL MANAGEMENT LLC | 8.9% | $6,702,907 | 4,720,357 | TANG CAPITAL MANAGEMENT, LLC | 16 Sep 2025 | |||
| BML Investment Partners, L.P. | 6.7% | $3,258,683 | 3,466,684 | BML Investment Partners, L.P. | 31 Dec 2024 | |||
| Sio Capital Management, LLC | 5% | -32% | $3,691,167 | -$1,538,387 | 2,636,548 | -29% | Sio Capital Management, LLC | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 11% | 5,975,291 | -7.7% | 0.2% | $8,365,407 |
| BML Capital Management, LLC | 10% | 5,292,000 | +5.8% | 6.8% | $7,408,800 |
| TANG CAPITAL MANAGEMENT LLC | 9% | 4,785,201 | 0.26% | $6,699,281 | |
| ArrowMark Colorado Holdings LLC | 6.2% | 3,301,341 | +3.6% | 0.09% | $4,621,877 |
| Sio Capital Management, LLC | 5% | 2,636,548 | -29% | 0.93% | $3,691,167 |
| Euclidean Capital LLC | 5% | 2,627,643 | 0% | 1.5% | $3,678,700 |
| VANGUARD GROUP INC | 4.1% | 2,163,027 | +0.44% | 0% | $3,028,239 |
| ACADIAN ASSET MANAGEMENT LLC | 3.9% | 2,066,137 | 0% | 0.01% | $2,891,000 |
| Stonepine Capital Management, LLC | 2.6% | 1,370,139 | +62% | 1.6% | $1,918,195 |
| BlackRock, Inc. | 2.1% | 1,104,140 | -3.2% | 0% | $1,545,795 |
| MARSHALL WACE, LLP | 1.2% | 612,626 | 0% | $857,677 | |
| Aldebaran Capital, LLC | 0.95% | 504,128 | -2.1% | 0.65% | $705,779 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.82% | 431,820 | -0.2% | 0% | $604,698 |
| TWO SIGMA ADVISERS, LP | 0.79% | 417,900 | -14% | 0% | $585,060 |
| JANE STREET GROUP, LLC | 0.72% | 382,050 | 0% | $534,870 | |
| NORTHERN TRUST CORP | 0.72% | 380,813 | +229% | 0% | $533,138 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0.61% | 320,653 | +115% | 0.01% | $448,914 |
| Walleye Capital LLC | 0.53% | 278,459 | +258% | 0% | $389,843 |
| TWO SIGMA INVESTMENTS, LP | 0.51% | 269,621 | -7.5% | 0% | $377,469 |
| RBF Capital, LLC | 0.46% | 245,561 | 0% | 0.02% | $343,785 |
| Peapod Lane Capital LLC | 0.38% | 202,784 | -55% | 0.25% | $283,908 |
| BOOTHBAY FUND MANAGEMENT, LLC | 0.38% | 201,498 | 0.01% | $282,097 | |
| CITADEL ADVISORS LLC | 0.36% | 193,153 | -25% | 0% | $270,414 |
| GOLDMAN SACHS GROUP INC | 0.32% | 170,802 | +80% | 0% | $239,123 |
| BANK OF AMERICA CORP /DE/ | 0.31% | 162,496 | +458% | 0% | $227,495 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 140,468 | $175,585 | +$21,720 | 125% | 1 |
| 2025 Q3 | 37,493,102 | $52,489,395 | +$4,773,977 | 140% | 63 |
| 2025 Q2 | 34,680,709 | $36,758,763 | -$4,239,299 | 106% | 52 |
| 2025 Q1 | 37,320,031 | $40,676,123 | -$2,281,128 | 109% | 54 |
| 2024 Q4 | 38,959,310 | $58,833,243 | -$767,789 | 151% | 70 |
| 2024 Q3 | 39,023,873 | $58,153,846 | -$2,418,248 | 149% | 73 |
| 2024 Q2 | 40,492,507 | $65,596,312 | -$3,783,568 | 162% | 92 |
| 2024 Q1 | 42,725,320 | $72,627,650 | -$11,892,451 | 170% | 96 |
| 2023 Q4 | 16,882 | $52,334 | 310% | 1 | |
| 2023 Q3 | 54,236,025 | $333,005,773 | +$15,570,828 | 614% | 103 |
| 2023 Q2 | 51,666,984 | $323,502,051 | +$3,130,604 | 626% | 103 |
| 2023 Q1 | 51,513,177 | $245,718,480 | -$16,151,013 | 477% | 111 |
| 2022 Q4 | 54,540,445 | $474,497,276 | -$38,235,770 | 870% | 112 |
| 2022 Q3 | 58,031,251 | $690,573,229 | -$34,715,020 | 1,190% | 111 |
| 2022 Q2 | 60,352,324 | $859,930,498 | +$72,090,452 | 1,425.01% | 101 |
| 2022 Q1 | 50,860,352 | $1,058,686,944 | +$77,709,829 | 2,082% | 97 |
| 2021 Q4 | 47,118,669 | $1,088,471,184 | +$8,193,543 | 2,310.02% | 98 |
| 2021 Q3 | 43,990,496 | $1,310,909,931 | +$46,705,400 | 2,979.99% | 91 |
| 2021 Q2 | 42,211,615 | $1,441,945,792 | +$79,727,781 | 3,416% | 81 |
| 2021 Q1 | 39,912,275 | $1,312,717,295 | +$51,997,940 | 3,289.01% | 80 |
| 2020 Q4 | 38,212,089 | $2,335,342,669 | +$192,149,491 | 6,151% | 72 |
| 2020 Q3 | 31,212,908 | $1,098,804,001 | +$1,098,803,843 | 3,550% | 51 |